Altered orbitofrontal sulcogyral patterns in adult males with high-functioning autism spectrum disorders.

Functions of the orbitofrontal cortex include diverse social, cognitive and affective processes, many of which are abnormal in autism spectrum disorders (ASDs). Recently, altered orbitofrontal sulcogyral patterns have been revealed in several psychiatric conditions, such as schizophrenia, indicating a possibility that altered orbitofrontal sulcogyral morphology reflects abnormal neurodevelopment. However, the presence of sulcal alterations in ASD remains unexplored. Using structural magnetic resonance imaging, subtypes of the 'H-shaped' sulcus (Type I, II and III, in order of frequency), posterior orbital sulcus (POS) and intermediate orbital sulcus were identified in each hemisphere of adult males with ASD (n = 51) and matched normal controls (n = 55) based on the study by Chiavaras and Petrides. ASD showed a significantly altered distribution of H-shaped sulcal subtypes in both hemispheres, with a significant increase of Type III. A significant alteration in the distribution of sulcal subtypes was also identified in the right hemisphere POS of ASD. Categorical regression analysis revealed that Type I and II expressions predicted a reduced total Autism-Spectrum Quotient score. Furthermore, Type I expression was associated with a reduced 'attention to detail' subscale score. The results demonstrate that altered sulcogyral morphology can be a marker for abnormal neurodevelopment leading to the increased risk of developing autism.

[1]  E. Rolls,et al.  The Orbitofrontal Cortex , 2019 .

[2]  太郎 福榮,et al.  Japanese Adult Reading Test(JART)と認知機能障害との関連 , 2013 .

[3]  J. Martineau,et al.  Functional morphological imaging of autism spectrum disorders: current position and theories proposed. , 2012, Diagnostic and interventional imaging.

[4]  Arthur W. Toga,et al.  The Unique Brain Anatomy of Meditation Practitioners: Alterations in Cortical Gyrification , 2012, Front. Hum. Neurosci..

[5]  S. Lawrie,et al.  A systematic review and meta-analysis of the fMRI investigation of autism spectrum disorders , 2012, Neuroscience & Biobehavioral Reviews.

[6]  S. Frangou,et al.  Autism Spectrum Disorders and Schizophrenia: Meta-Analysis of the Neural Correlates of Social Cognition , 2011, PloS one.

[7]  Jong H. Yoon,et al.  From lumping to splitting and back again: Atypical social and language development in individuals with clinical-high-risk for psychosis, first episode schizophrenia, and autism spectrum disorders , 2011, Schizophrenia Research.

[8]  M. Shenton,et al.  Sexually dimorphic distribution of orbitofrontal sulcogyral pattern in schizophrenia , 2011, Psychiatry and clinical neurosciences.

[9]  J. Parnas.  A Disappearing Heritage: The Clinical Core of Schizophrenia , 2011, Schizophrenia bulletin.

[10]  S. Nagarajan,et al.  Sensory Processing in Autism: A Review of Neurophysiologic Findings , 2011, Pediatric Research.

[11]  F. Happé,et al.  Meta-analysis of gray matter abnormalities in autism spectrum disorder: should Asperger disorder be subsumed under a broader umbrella of autistic spectrum disorder? , 2011, Archives of general psychiatry.

[12]  E. Johnstone,et al.  Orbitofrontal morphology in people at high risk of developing schizophrenia , 2010, European Psychiatry.

[13]  Clive H. Y. Wong,et al.  Autistic Disorders and Schizophrenia: Related or Remote? An Anatomical Likelihood Estimation , 2010, PloS one.

[14]  H. Yamasue,et al.  Volume reduction and altered sulco-gyral pattern of the orbitofrontal cortex in first-episode schizophrenia , 2010, Schizophrenia Research.

[15]  E. L. Mortensen,et al.  Core of Schizophrenia: Estrangement, Dementia or Neurocognitive Disorder? , 2010, Psychopathology.

[16]  Y. Hirayasu,et al.  Posterior orbitofrontal sulcogyral pattern associated with orbitofrontal cortex volume reduction and anxiety trait in panic disorder , 2010, Psychiatry and clinical neurosciences.

[17]  Yun Jiao,et al.  Predictive models of autism spectrum disorder based on brain regional cortical thickness , 2010, NeuroImage.

[18]  Laurence Faivre,et al.  Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation. , 2009, Archives of general psychiatry.

[19]  Mark H Lewis,et al.  The pathophysiology of restricted repetitive behavior , 2009, Journal of Neurodevelopmental Disorders.

[20]  J. Hornak,et al.  Social and emotional functioning following bilateral and unilateral neurosurgical prefrontal cortex lesions. , 2009, Journal of neuropsychology.

[21]  B. Aouizerate,et al.  Meta-Analysis of Brain Volume Changes in Obsessive-Compulsive Disorder , 2009, Biological Psychiatry.

[22]  B. Peterson,et al.  The neural bases of obsessive–compulsive disorder in children and adults , 2008, Development and Psychopathology.

[23]  F. Lazeyras,et al.  Mapping the early cortical folding process in the preterm newborn brain. , 2008, Cerebral cortex.

[24]  D. Boomsma,et al.  Factor Structure, Reliability and Criterion Validity of the Autism-Spectrum Quotient (AQ): A Study in Dutch Population and Patient Groups , 2008, Journal of autism and developmental disorders.

[25]  R. McCarley,et al.  Orbitofrontal volume deficit in schizophrenia and thought disorder. , 2007, Brain : a journal of neurology.

[26]  S. Dane,et al.  Handedness, eyedness and nasal cycle in children with autism , 2007, International Journal of Developmental Neuroscience.

[27]  Kenny Q. Ye,et al.  Strong Association of De Novo Copy Number Mutations with Autism , 2007, Science.

[28]  James J Levitt,et al.  Altered orbitofrontal sulcogyral pattern in schizophrenia. , 2007, Brain : a journal of neurology.

[29]  Matcheri S. Keshavan,et al.  Volumetric alterations of the orbitofrontal cortex in autism , 2007, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[30]  Jocelyne Bachevalier,et al.  The Orbitofrontal–amygdala Circuit and Self-regulation of Social–emotional Behavior in Autism , 2022 .

[31]  M. Reite,et al.  Regional gray matter volumetric changes in autism associated with social and repetitive behavior symptoms , 2006, BMC psychiatry.

[32]  V. Stenger.  Technical considerations for BOLD fMRI of the orbitofrontal cortex , 2006 .

[33]  Akio Wakabayashi,et al.  The Autism-Spectrum Quotient (AQ) in Japan: A Cross-Cultural Comparison , 2006, Journal of autism and developmental disorders.

[34]  Y. Burnod,et al.  A morphogenetic model for the development of cortical convolutions. , 2005, Cerebral cortex.

[35]  M. Roesch,et al.  Orbitofrontal Cortex, Associative Learning, and Expectancies , 2005, Neuron.

[36]  Tomonori Koyama,et al.  Autism‐Spectrum Quotient–Japanese version and its short forms for screening normally intelligent persons with pervasive developmental disorders , 2005, Psychiatry and clinical neurosciences.

[37]  M. Mehmet Haznedar,et al.  Striatal Volume on Magnetic Resonance Imaging and Repetitive Behaviors in Autism , 2005, Biological Psychiatry.

[38]  E. Rolls,et al.  The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology , 2004, Progress in Neurobiology.

[39]  J. Price,et al.  Architectonic subdivision of the human orbital and medial prefrontal cortex , 2003, The Journal of comparative neurology.

[40]  S. Baron-Cohen.  The extreme male brain theory of autism , 2002, Trends in Cognitive Sciences.

[41]  Deborah Dewey,et al.  Hand Preference and Motor Functioning in Children with Autism , 2001, Journal of autism and developmental disorders.

[42]  M. Lauritsen,et al.  The genetics of autism , 2001, Acta psychiatrica Scandinavica.

[43]  S. Baron-Cohen,et al.  The Autism-Spectrum Quotient (AQ): Evidence from Asperger Syndrome/High-Functioning Autism, Malesand Females, Scientists and Mathematicians , 2001, Journal of autism and developmental disorders.

[44]  M. Petrides,et al.  Orbitofrontal sulci of the human and macaque monkey brain , 2000, The Journal of comparative neurology.

[45]  D. V. von Cramon,et al.  Sulcal variability of twins. , 1999, Cerebral cortex.

[46]  M. Turner,et al.  Annotation: Repetitive behaviour in autism: a review of psychological research. , 1999, Journal of child psychology and psychiatry, and allied disciplines.

[47]  Joseph Piven,et al.  An MRI study of the basal ganglia in autism , 1999, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[48]  D. Weinberger,et al.  Genetic variability of human brain size and cortical gyral patterns. , 1997, Brain : a journal of neurology.

[49]  D. Pandya,et al.  Architecture and intrinsic connections of the prefrontal cortex in the rhesus monkey , 1989, The Journal of comparative neurology.

[50]  P. Rakic.  Specification of cerebral cortical areas. , 1988, Science.

[51]  C. Gillberg.  Autistic children's hand preferences: Results from an epidemiological study of infantile autism , 1983, Psychiatry Research.

[52]  F. Gilles,et al.  Gyral development of the human brain , 1977, Transactions of the American Neurological Association.

[53]  R. C. Oldfield.  The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[54]  Tony Charman,et al.  Testing the construct validity of proposed criteria for DSM-5 autism spectrum disorder. , 2012, Journal of the American Academy of Child and Adolescent Psychiatry.

[55]  Colin Studholme,et al.  Early folding patterns and asymmetries of the normal human brain detected from in utero MRI. , 2012, Cerebral cortex.

[56]  Deanna Greenstein,et al.  Autism spectrum disorders and childhood-onset schizophrenia: clinical and biological contributions to a relation revisited. , 2009, Journal of the American Academy of Child and Adolescent Psychiatry.

[57]  D. Sheehan,et al.  The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. , 1998, The Journal of clinical psychiatry.

[58]  D. V. van Essen,et al.  A tension-based theory of morphogenesis and compact wiring in the central nervous system. , 1997, Nature.

[59]  A. Schleicher,et al.  The ontogeny of human gyrification. , 1995, Cerebral cortex.