PPAR expression and function during vertebrate development.

The peroxisome proliferator activated receptors (PPARs) are ligand activated receptors which belong to the nuclear hormone receptor family. As with other members of this superfamily, it is thought that the ability of PPAR to bind to a ligand was acquired during metazoan evolution. Three different PPAR isotypes (PPARalpha, PPARbeta, also called 6, and PPARgamma) have been identified in various species. Upon binding to an activator, these receptors stimulate the expression of target genes implicated in important metabolic pathways. The present article is a review of PPAR expression and involvement in some aspects of Xenopus laevis and rodent embryonic development. PPARalpha and beta are ubiquitously expressed in Xenopus early embryos but become more tissue restricted later in development. In rodents, PPARalpha, PPARbeta and PPARgamma show specific time- and tissue-dependent patterns of expression during fetal development and in the adult animals. PPARs are implicated in several aspects of tissue differentiation and rodent development, such as differentiation of the adipose tissue, brain, placenta and skin. Particular attention is given to studies undertaken by us and others on the implication of PPARalpha and beta in rodent epidermal differentiation.

[1]  A. Mahfoudi,et al.  Positive regulation of the peroxisomal β‐oxidation pathway by fatty acids through activation of peroxisome proliferator‐activated receptors (PPAR) , 1993, Biology of the cell.

[2]  K. Kristiansen,et al.  Modulation of keratinocyte gene expression and differentiation by PPAR-selective ligands and tetradecylthioacetic acid. , 2001, The Journal of investigative dermatology.

[3]  K. Bhakoo,et al.  Distribution of mRNAs Encoding the Peroxisome Proliferator‐Activated Receptor α, β, and γ and the Retinoid X Receptor α, β, and γ in Rat Central Nervous System , 1998 .

[4]  G. Ailhaud,et al.  Peroxisome proliferator-activated receptor-alpha enhances lipid metabolism in a skin equivalent model. , 2000, The Journal of investigative dermatology.

[5]  P. Elias,et al.  Keratinocyte differentiation in hyperproliferative epidermis: topical application of PPARalpha activators restores tissue homeostasis. , 2000, The Journal of investigative dermatology.

[6]  W. Wahli,et al.  Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding. , 2001, Endocrinology.

[7]  L. Domenjoud,et al.  Differential Expression of Peroxisome Proliferator-activated Receptors (PPARs) in the Developing Human Fetal Digestive Tract , 2000, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[8]  W. Wahli,et al.  PPARα Structure-Function Relationships Derived from Species-Specific Differences in Responsiveness to Hypolipidemic Agents , 1997, Biological chemistry.

[9]  B. Spiegelman,et al.  PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. , 1999, Molecular cell.

[10]  W. Wahli,et al.  Differential expression of peroxisome proliferator-activated receptor-alpha, -beta, and -gamma during rat embryonic development. , 1998, Endocrinology.

[11]  B. Spiegelman,et al.  PPARγ: a Nuclear Regulator of Metabolism, Differentiation, and Cell Growth* , 2001, The Journal of Biological Chemistry.

[12]  P. Elias,et al.  Fetal epidermal differentiation and barrier development In vivo is accelerated by nuclear hormone receptor activators. , 1999, The Journal of investigative dermatology.

[13]  V. Laudet,et al.  Ligand binding and nuclear receptor evolution , 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.

[14]  K. Chien,et al.  PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development , 1999 .

[15]  T. Willson,et al.  Peroxisome proliferator activated receptor agonists. , 1997, EXS.

[16]  C. Dreyer,et al.  Retinoic acid receptors and nuclear orphan receptors in the development of Xenopus laevis. , 1996, The International journal of developmental biology.

[17]  K. Umesono,et al.  Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[18]  J. Lehmann,et al.  A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[19]  R. Smart,et al.  Correlation between expression of peroxisome proliferator-activated receptor β and squamous differentiation in epidermal and tracheobronchial epithelial cells , 1999, Molecular and Cellular Endocrinology.

[20]  W. Wahli,et al.  Peroxisome Proliferator-activated Receptor β Regulates Acyl-CoA Synthetase 2 in Reaggregated Rat Brain Cell Cultures* , 1999, The Journal of Biological Chemistry.

[21]  W. Wahli,et al.  Printed in U.S.A. Copyright © 1998 by The Endocrine Society Differential Expression of Peroxisome Proliferator- Activated Receptor-�,-�, and- � during Rat , 2022 .

[22]  K. Griffin,et al.  Peroxisome proliferator activated receptor-alpha expression in human liver. , 1998, Molecular pharmacology.

[23]  W. Wahli,et al.  Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. , 1996, Endocrinology.

[24]  K. Feingold,et al.  Glucocorticoids accelerate fetal maturation of the epidermal permeability barrier in the rat. , 1993, The Journal of clinical investigation.

[25]  J. Auwerx,et al.  Stimulation of PPARα Promotes Epidermal Keratinocyte Differentiation In Vivo , 2000 .

[26]  K. Bhakoo,et al.  Distribution of mRNAs encoding the peroxisome proliferator-activated receptor alpha, beta, and gamma and the retinoid X receptor alpha, beta, and gamma in rat central nervous system. , 1998, Journal of neurochemistry.

[27]  B. Spiegelman,et al.  PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro , 1999 .

[28]  P. Grimaldi,et al.  The roles of PPARs in adipocyte differentiation. , 2001, Progress in lipid research.

[29]  Robert N. Taylor,et al.  Placental peroxisome proliferator-activated receptor-γ is up-regulated by pregnancy serum , 2000 .

[30]  J. Morrow,et al.  Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta. , 1999, Genes & development.

[31]  B. Spiegelman,et al.  PPARgamma : a nuclear regulator of metabolism, differentiation, and cell growth. , 2001, The Journal of biological chemistry.

[32]  W. Wahli,et al.  Critical roles of PPAR beta/delta in keratinocyte response to inflammation. , 2001, Genes & development.

[33]  S. Aizawa,et al.  PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. , 1999, Molecular cell.

[34]  W. Wahli,et al.  Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. , 1997, Molecular endocrinology.

[35]  T. Pineau,et al.  Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators , 1995, Molecular and cellular biology.

[36]  Y. Sadovsky,et al.  Peroxisome proliferator-activated receptor-γ modulates differentiation of human trophoblast in a ligand-specific manner , 2000 .

[37]  W. J. Brammar,et al.  The ontogeny of peroxisome-proliferator-activated receptor gene expression in the mouse and rat , 1992, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[38]  J. Auwerx,et al.  Tissue Distribution and Quantification of the Expression of mRNAs of Peroxisome Proliferator–Activated Receptors and Liver X Receptor-α in Humans: No Alteration in Adipose Tissue of Obese and NIDDM Patients , 1997, Diabetes.

[39]  J. Ward,et al.  Growth, Adipose, Brain, and Skin Alterations Resulting from Targeted Disruption of the Mouse Peroxisome Proliferator-Activated Receptor β(δ) , 2000, Molecular and Cellular Biology.

[40]  P. Elias,et al.  Keratinocyte differentiation is stimulated by activators of the nuclear hormone receptor PPARalpha. , 1998, The Journal of investigative dermatology.

[41]  W. Wahli,et al.  Peroxisome proliferator-activated receptors: nuclear control of metabolism. , 1999, Endocrine reviews.

[42]  R. Evans,et al.  PPAR gamma is required for placental, cardiac, and adipose tissue development. , 1999, Molecular cell.

[43]  G. Ailhaud,et al.  Differential expression of peroxisome proliferator-activated receptor subtypes during the differentiation of human keratinocytes. , 1998, The Journal of investigative dermatology.

[44]  J. Auwerx,et al.  Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo. , 2000, The Journal of investigative dermatology.

[45]  K. Lim,et al.  Placental peroxisome proliferator-activated receptor-gamma is up-regulated by pregnancy serum. , 2000, The Journal of clinical endocrinology and metabolism.

[46]  P. Chambon,et al.  Skin abnormalities generated by temporally controlled RXRα mutations in mouse epidermis , 2000, Nature.

[47]  I. Issemann,et al.  Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators , 1990, Nature.

[48]  Daniel Metzger,et al.  Impaired skin wound healing in peroxisome proliferator–activated receptor (PPAR)α and PPARβ mutant mice , 2001, The Journal of cell biology.

[49]  Christine Dreyer,et al.  Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors , 1992, Cell.

[50]  L. Domenjoud,et al.  Implications of peroxisome proliferator-activated receptors (PPARS) in development, cell life status and disease. , 2000, The International journal of developmental biology.

[51]  W. Wahli,et al.  Peroxisome proliferator-activated receptors: insight into multiple cellular functions. , 2000, Mutation research.

[52]  N. Messaddeq,et al.  RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations. , 2001, Development.

[53]  Sander Kersten,et al.  Roles of PPARs in health and disease , 2000, Nature.

[54]  J. Paterniti,et al.  Identification, Characterization, and Tissue Distribution of Human Peroxisome Proliferator-activated Receptor (PPAR) Isoforms PPARγ2 versus PPARγ1 and Activation with Retinoid X Receptor Agonists and Antagonists* , 1997, The Journal of Biological Chemistry.

[55]  S. Smith,et al.  The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2000 by The Endocrine Society Peroxisome Proliferator-Activated Receptor- � Modulates Differentiation of Human Trophoblast in a Ligand-Specific Manner* , 2022 .

[56]  U. Rassner,et al.  Epidermal barrier ontogenesis: maturation in serum-free media and acceleration by glucocorticoids and thyroid hormone but not selected growth factors. , 1996, The Journal of investigative dermatology.