Peripheral Arterial Disease in the Elderly

The prevalence of peripheral arterial disease (PAD) increases with age and can impact quality of life and independence in this population. Understanding risk factors for the disease and its natural history is key to informed conversations with patients. Here we review approaches to diagnosis, medical management, exercise therapy, and revascularization for older patients across the spectrum of PAD. Patient education, lifestyle and risk factor modification, medical therapies, and exercise are cornerstones of treatment for PAD in all age groups. Clinical decision-making in elderly patients with advanced PAD requires a careful assessment of physiologic reserve, surgical risk, desired goals, and expected outcomes. An increasing array of options facilitates a tailored approach.

[1]  H. Aihara,et al.  Comparison of long-term outcome after endovascular therapy versus bypass surgery in claudication patients with Trans-Atlantic Inter-Society Consensus-II C and D femoropopliteal disease. , 2014, Circulation journal : official journal of the Japanese Circulation Society.

[2]  Luigi Ferrucci,et al.  Functional decline in peripheral arterial disease: associations with the ankle brachial index and leg symptoms. , 2004, JAMA.

[3]  Laura G. Qualls,et al.  Trends in settings for peripheral vascular intervention and the effect of changes in the outpatient prospective payment system. , 2015, Journal of the American College of Cardiology.

[4]  V. Moyer Screening for Peripheral Artery Disease and Cardiovascular Disease Risk Assessment With the Ankle–Brachial Index in Adults: U.S. Preventive Services Task Force Recommendation Statement , 2013, Annals of Internal Medicine.

[5]  Functional status of elderly adults before and after interventions for critical limb ischemia. , 2013, Journal of vascular surgery.

[6]  I. Baumgartner,et al.  Revascularization for chronic critical lower limb ischemia in octogenarians is worthwhile. , 2007, Journal of vascular surgery.

[7]  A. Meltzer,et al.  Safety and effectiveness of endovascular therapy for claudication in octogenarians. , 2015, Annals of vascular surgery.

[8]  C. Reid,et al.  Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: a randomized controlled trial. , 2013, JAMA.

[9]  Rodney A. White,et al.  ACC/AHA 2005 guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): executive summary a collaborative report from the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Ang , 2006, Journal of the American College of Cardiology.

[10]  Igor Rudan,et al.  Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis , 2013, The Lancet.

[11]  J. Forbes,et al.  Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) trial: A survival prediction model to facilitate clinical decision making. , 2010, Journal of vascular surgery.

[12]  Deepak L. Bhatt,et al.  Vascular Hospitalization Rates and Costs in Patients With Peripheral Artery Disease in the United States , 2010, Circulation. Cardiovascular quality and outcomes.

[13]  T. Gill,et al.  Ankle Brachial Index Values, Leg Symptoms, and Functional Performance Among Community‐Dwelling Older Men and Women in the Lifestyle Interventions and Independence for Elders Study , 2013, Journal of the American Heart Association.

[14]  Nancy M Albert,et al.  Management of patients with peripheral artery disease (compilation of 2005 and 2011 ACCF/AHA guideline recommendations): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. , 2013, Circulation.

[15]  A. Gardner,et al.  Natural history of physical function in older men with intermittent claudication. , 2004, Journal of vascular surgery.

[16]  L. Jivegård,et al.  Six-minute walk test closely correlates to "real-life" outdoor walking capacity and quality of life in patients with intermittent claudication. , 2014, Journal of vascular surgery.

[17]  H. Furukawa,et al.  Bypass vs. Endovascular Therapy of Infrapopliteal Lesions for Critical Limb Ischemia. , 2014, Annals of vascular diseases.

[18]  P. Dijkstra,et al.  Change in health-related quality of life in the first 18 months after lower limb amputation: a prospective, longitudinal study. , 2013, Journal of rehabilitation medicine.

[19]  P. Dijkstra,et al.  Mobility in elderly people with a lower limb amputation: a systematic review. , 2012, Journal of the American Medical Directors Association.

[20]  M. Venermo,et al.  The benefit of revascularization in nonagenarians with lower limb ischemia is limited by high mortality. , 2015, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[21]  E. Housley Treating claudication in five words , 1988, British medical journal.

[22]  L. Sharma,et al.  Depressive symptoms and lower extremity functioning in men and women with peripheral arterial disease , 2003, Journal of General Internal Medicine.

[23]  M. Dijkgraaf,et al.  Changes in functional status after treatment of critical limb ischemia. , 2013, Journal of vascular surgery.

[24]  Daniel J. Bertges,et al.  Predicting functional status following amputation after lower extremity bypass. , 2012, Annals of vascular surgery.

[25]  J. Chang,et al.  Infrainguinal revascularizations in octogenarians and septuagenarians. , 2001, Journal of vascular surgery.

[26]  Elizabeth Selvin,et al.  Prevalence of and Risk Factors for Peripheral Arterial Disease in the United States: Results From the National Health and Nutrition Examination Survey, 1999–2000 , 2004 .

[27]  L. Norgren,et al.  The next 10 years in the management of peripheral artery disease: perspectives from the 'PAD 2009' Conference. , 2010, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[28]  Lu Tian,et al.  Physical Performance in Peripheral Arterial Disease: A Slower Rate of Decline in Patients Who Walk More , 2006, Annals of Internal Medicine.

[29]  J. Mega,et al.  Risk stratification in critical limb ischemia: derivation and validation of a model to predict amputation-free survival using multicenter surgical outcomes data. , 2008, Journal of vascular surgery.

[30]  J. Cronenwett,et al.  Outcomes and practice patterns in patients undergoing lower extremity bypass. , 2012, Journal of vascular surgery.

[31]  F. Biancari,et al.  Risk-scoring Method for Prediction of 30-Day Postoperative Outcome after Infrainguinal Surgical Revascularization for Critical Lower-limb Ischemia: a Finnvasc Registry Study , 2006, World Journal of Surgery.

[32]  A. Meltzer,et al.  The Comprehensive Risk Assessment for Bypass (CRAB) facilitates efficient perioperative risk assessment for patients with critical limb ischemia. , 2013, Journal of vascular surgery.

[33]  J. Bosma,et al.  Systematic review on health-related quality of life after revascularization and primary amputation in patients with critical limb ischemia. , 2013, Annals of vascular surgery.

[34]  J. Mckinsey,et al.  Correction: Society for Vascular Surgery practice guidelines for atherosclerotic occlusive disease of the lower extremities: Management of asymptomatic disease and claudication (Journal of Vascular Surgery (2015) 61(3S) (2S-41S)) , 2015 .

[35]  Umair Qazi,et al.  Comparison of surgical bypass with angioplasty and stenting of superficial femoral artery disease. , 2014, Journal of vascular surgery.

[36]  R. Ritti-Dias,et al.  Are the barriers for physical activity practice equal for all peripheral artery disease patients? , 2015, Archives of physical medicine and rehabilitation.

[37]  K. Bailey,et al.  Frailty Across the Spectrum of Ankle-Brachial Index , 2012, Angiology.

[38]  E. Vittinghoff,et al.  Peripheral arterial disease, gender, and depression in the Heart and Soul Study. , 2014, Journal of vascular surgery.

[39]  S. Blevins,et al.  Efficacy of Quantified Home-Based Exercise and Supervised Exercise in Patients With Intermittent Claudication: A Randomized Controlled Trial , 2011, Circulation.

[40]  L. Norgren,et al.  Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). , 2007, Journal of vascular surgery.

[41]  T. Schroeder,et al.  Fate in intermittent claudication: outcome and risk factors. , 1986, British medical journal.

[42]  J. Birkmeyer,et al.  Regional intensity of vascular care and lower extremity amputation rates. , 2013, Journal of vascular surgery.

[43]  M Hassan Murad,et al.  Society for Vascular Surgery practice guidelines for atherosclerotic occlusive disease of the lower extremities: management of asymptomatic disease and claudication. , 2015, Journal of vascular surgery.

[44]  P. Holt,et al.  The BASIL survival prediction model in patients with peripheral arterial disease undergoing revascularization in a university hospital setting and comparison with the FINNVASC and modified PREVENT scores. , 2013, Journal of vascular surgery.

[45]  J. Forbes,et al.  Bypass versus angioplasty in severe ischaemia of the leg (BASIL): multicentre, randomised controlled trial , 2005, The Lancet.

[46]  E. Finlayson,et al.  Functional outcomes after lower extremity revascularization in nursing home residents: a national cohort study. , 2015, JAMA internal medicine.