YAP-PET: a small animal positron emission tomograph based on YAP:Ce finger crystals

The authors have built a small animal positron emission tomograph (YAP-PET) based on four matrices of 400 YAP:Ce finger crystals (2/spl times/2/spl times/30 mm/sup 3/ each) coupled to Hamamatsu R2486-06 position sensitive photomultipliers. The system consists of four detectors on a rotating gantry with a variable diameter between 10 and 25 cm. The read-out and data acquisition system are handled by off-shelf electronics and are controlled by in house developed programs. The tomograph has a total FOV of 4/spl times/4/spl times/4 cm/sup 3/ that is appropriate for mice and rat studies. A spatial resolution /spl les/2 mm over the useful FOV of 2/spl times/2/spl times/2 cm/sup 3/ has been measured, with an average sensitivity of about 730 cps//spl mu/Ci for a gantry diameter of 15 cm and an energy threshold of 50 keV.

[1]  J. Colsher,et al.  Fully-three-dimensional positron emission tomography , 1980, Physics in medicine and biology.

[2]  A. Del Guerra,et al.  High spatial resolution small animal YAP-PET , 1998 .

[3]  Roberto Pani,et al.  Use of a YAP:Ce matrix coupled to a position-sensitive photomultiplier for high resolution positron emission tomography , 1995 .

[4]  A. Del Guerra,et al.  Sub-millimeter planar imaging with positron emitters: EGS4 code simulation and experimental results , 1996, 1996 IEEE Nuclear Science Symposium. Conference Record.

[5]  D. Townsend,et al.  Increased sensitivity and field of view for a rotating positron camera. , 1984, Physics in Medicine and Biology.

[6]  T J Spinks,et al.  The design and physical characteristics of a small animal positron emission tomograph. , 1995, Physics in medicine and biology.

[7]  M E Phelps,et al.  Design features and performance of a PET system for animal research. , 1992, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[8]  R Lecomte,et al.  High-resolution PET imaging and quantitation of pharmaceutical biodistributions in a small animal using avalanche photodiode detectors. , 1994, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[9]  R. Hichwa,et al.  Are animal scanners really necessary for PET? , 1994, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.