Use of topological descriptiors in chromatographic chiral separations

Abstract Studies of enantiomeric separations are reported, specifically the direct chromatographic separation of enantiomers using a chiral stationary phase by molecular topology. The results obtained show good correlation equations for the capacity factor, k ′, and the separation factor, α, for different set of compounds (hydantoins, aromatic α-amino acids and arylamides). Such equations may be useful for the selection of the optimum stationary and mobile phases for the separation of enantiomers. Futher, the correlation between topological descriptors and performance in chiral separations opens up a new approach to the design of chiral stationary phases.