GITR+ regulatory T cells in the treatment of autoimmune diseases.
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[1] C. Riccardi,et al. Expansion of regulatory GITR+CD25low/-CD4+ T cells in systemic lupus erythematosus patients , 2014, Arthritis Research & Therapy.
[2] E. Gelfand,et al. JNK2 Regulates the Functional Plasticity of Naturally Occurring T Regulatory Cells and the Enhancement of Lung Allergic Responses , 2014, The Journal of Immunology.
[3] S. Sakaguchi,et al. TREG-cell therapies for autoimmune rheumatic diseases , 2014, Nature Reviews Rheumatology.
[4] C. Riccardi,et al. GILZ promotes production of peripherally induced Treg cells and mediates the crosstalk between glucocorticoids and TGF-β signaling. , 2014, Cell reports.
[5] H. Einsele,et al. Human regulatory T cells are selectively activated by low‐dose application of the CD28 superagonist TGN1412/TAB08 , 2014, European journal of immunology.
[6] H. Akbari,et al. Iranian Journal of Basic Medical Sciences Numerical Status of Cd4 + Cd25 + Foxp3 + and Cd8 + Cd28 - Regulatory T Cells in Multiple Sclerosis , 2022 .
[7] C. Sautès-Fridman,et al. The immune contexture of primary and metastatic human tumours. , 2014, Current opinion in immunology.
[8] M. Farrar,et al. Tumor necrosis factor receptor superfamily costimulation couples T cell receptor signal strength to thymic regulatory T cell differentiation , 2014, Nature Immunology.
[9] Lei Lu,et al. Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs , 2014, Journal of Translational Medicine.
[10] R. de Waal Malefyt,et al. Glucocorticoid-Induced TNF Receptor Family-Related Protein Ligand is Requisite for Optimal Functioning of Regulatory CD4+ T Cells , 2014, Front. Immunol..
[11] Elizabeth Whalen,et al. Multiple Autoimmune-Associated Variants Confer Decreased IL-2R Signaling in CD4+CD25hi T Cells of Type 1 Diabetic and Multiple Sclerosis Patients , 2013, PloS one.
[12] M. Roncarolo,et al. Immunological Outcome in Haploidentical-HSC Transplanted Patients Treated with IL-10-Anergized Donor T Cells , 2013, Front. Immunol..
[13] F. Carbone,et al. Regulatory T cell proliferative potential is impaired in human autoimmune disease , 2013, Nature Medicine.
[14] D. Klatzmann,et al. Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial. , 2013, The lancet. Diabetes & endocrinology.
[15] B. Nakken,et al. Altered Th17 cells and Th17/regulatory T-cell ratios indicate the subsequent conversion from undifferentiated connective tissue disease to definitive systemic autoimmune disorders. , 2013, Human immunology.
[16] A. D. De Groot,et al. Beyond humanization and de-immunization: tolerization as a method for reducing the immunogenicity of biologics , 2013, Expert review of clinical pharmacology.
[17] C. Roura-mir,et al. Low frequency of GITR+ T cells in ex vivo and in vitro expanded Treg cells from type 1 diabetic patients. , 2013, International immunology.
[18] C. Riccardi,et al. Characterization of CD4+ and CD8+ Tregs in a Hodgkin's lymphoma patient presenting with myasthenia-like symptoms. , 2013, Ideggyogyaszati szemle.
[19] J. Wolchok,et al. GITR Pathway Activation Abrogates Tumor Immune Suppression through Loss of Regulatory T-cell Lineage Stability , 2013, Cancer Immunology Research.
[20] V. Shaygannejad,et al. Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms , 2013, Journal of Neuroimmunology.
[21] S. Rutella,et al. FOXP3+ T Regulatory Cell Modifications in Inflammatory Bowel Disease Patients Treated with Anti-TNFα Agents , 2013, BioMed research international.
[22] G. Dranoff,et al. Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies , 2013, The Journal of experimental medicine.
[23] C. Riccardi,et al. Characterization of a new regulatory CD4+ T cell subset in primary Sjögren's syndrome. , 2013, Rheumatology.
[24] A. Levine,et al. Impairment of regulatory T-cell function in autoimmune thyroid disease. , 2013, Thyroid : official journal of the American Thyroid Association.
[25] J. Myśliwska,et al. Loss of the balance between CD4(+)Foxp3(+) regulatory T cells and CD4(+)IL17A(+) Th17 cells in patients with type 1 diabetes. , 2013, Human immunology.
[26] D. Tiezzi,et al. Enrichment of regulatory T cells in invasive breast tumor correlates with the upregulation of IL‐17A expression and invasiveness of the tumor , 2013, European journal of immunology.
[27] Nunzio Bottini,et al. In vivo targeting of intratumor regulatory T cells using PEG-modified single-walled carbon nanotubes. , 2013, Bioconjugate chemistry.
[28] C. M. Bonin,et al. Glucocorticoid-induced tumor necrosis factor receptor expression in patients with cervical human papillomavirus infection. , 2013, Revista da Sociedade Brasileira de Medicina Tropical.
[29] H. Nie,et al. Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis , 2013, Nature Medicine.
[30] Sebastian M. Armasu,et al. Inherited Variants in Regulatory T Cell Genes and Outcome of Ovarian Cancer , 2013, PloS one.
[31] Kumar Kuna,et al. Research Highlights and Editors’ Picks , 2013 .
[32] M. Moniuszko,et al. Lower proportions of CD4+CD25high and CD4+FoxP3, but not CD4+CD25+CD127low FoxP3+T cell levels in children with autoimmune thyroid diseases , 2013, Autoimmunity.
[33] M. Peppelenbosch,et al. Activated tumor‐infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer , 2013, Hepatology.
[34] J. Ha,et al. Subpopulations of Regulatory T Cells in Rheumatoid Arthritis, Systemic Lupus Erythematosus, and Behcet's Disease , 2012, Journal of Korean medical science.
[35] D. Perry,et al. Autologous Regulatory T Cells for the Treatment of Type 1 Diabetes , 2012, Current Diabetes Reports.
[36] C. Riccardi,et al. Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus: The Old and the New , 2012, Clinical & developmental immunology.
[37] M. Levings,et al. Regulatory T‐cell therapy for inflammatory bowel disease: more questions than answers , 2012, Immunology.
[38] Yijun Carrier,et al. Enhanced GITR/GITRL interactions augment IL‐27 expression and induce IL‐10‐producing Tr‐1 like cells , 2012, European journal of immunology.
[39] G. Scott,et al. Tumour Cell Generation of Inducible Regulatory T-Cells in Multiple Myeloma Is Contact-Dependent and Antigen-Presenting Cell-Independent , 2012, PloS one.
[40] W. Hawthorne,et al. Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice , 2012, Diabetes.
[41] C. Riccardi,et al. Pharmacological modulation of GITRL/GITR system: therapeutic perspectives , 2012, British journal of pharmacology.
[42] J. Wolchok,et al. Modulation of GITR for cancer immunotherapy. , 2012, Current opinion in immunology.
[43] E. Gelfand,et al. Loss of T Regulatory Cell Suppression following Signaling through Glucocorticoid-induced Tumor Necrosis Receptor (GITR) Is Dependent on c-Jun N-terminal Kinase Activation* , 2012, The Journal of Biological Chemistry.
[44] A. Rudensky,et al. Regulatory T cells: mechanisms of differentiation and function. , 2012, Annual review of immunology.
[45] T. Geiger,et al. Nature and nurture in Foxp3(+) regulatory T cell development, stability, and function. , 2012, Human immunology.
[46] Guangjie Chen,et al. IFN-β induces the proliferation of CD4+CD25+Foxp3+ regulatory T cells through upregulation of GITRL on dendritic cells in the treatment of multiple sclerosis , 2012, Journal of Neuroimmunology.
[47] E. Fischer-Fodor,et al. Gitr-Expressing Regulatory T-Cell Subsets are Increased in Tumor-Positive Lymph Nodes from Advanced Breast Cancer Patients as Compared to Tumor-Negative Lymph Nodes , 2012, International journal of immunopathology and pharmacology.
[48] M. Roncarolo,et al. The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells , 2011, Front. Immun..
[49] S. Sengupta,et al. Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors. , 2011, Neuro-oncology.
[50] H. Ikeuchi,et al. The CD4+CD28null and the regulatory CD4+CD25High T-cell phenotypes in patients with ulcerative colitis during active and quiescent disease, and following colectomy. , 2011, Cytokine.
[51] E. Shevach,et al. Polyclonal Treg cells modulate T effector cell trafficking , 2011, European journal of immunology.
[52] M. Edinger,et al. Regulatory T cells in stem cell transplantation: strategies and first clinical experiences. , 2011, Current opinion in immunology.
[53] Z. Amoura,et al. Human FoxP3+ regulatory T cells in systemic autoimmune diseases. , 2011, Autoimmunity reviews.
[54] C. Riccardi,et al. CD4+CD25lowGITR+ cells: A novel human CD4+ T‐cell population with regulatory activity , 2011, European journal of immunology.
[55] T. Akamizu,et al. Association of functional GITR gene polymorphisms related to expression of glucocorticoid‐induced tumour necrosis factor‐receptor (GITR) molecules with prognosis of autoimmune thyroid disease , 2011, Clinical and experimental immunology.
[56] Yi Wang,et al. Expression of CD4+ forkhead box P3 (FOXP3)+ regulatory T cells in inflammatory bowel disease , 2011, Journal of digestive diseases.
[57] S. Quataert,et al. Uncoupling of Proliferation and Cytokines From Suppression Within the CD4+CD25+Foxp3+ T–Cell Compartment in the 1st Year of Human Type 1 Diabetes , 2011, Diabetes.
[58] Hong Xiao,et al. TRAIL Is Associated with Impaired Regulation of CD4+CD25− T Cells by Regulatory T Cells in Patients with Rheumatoid Arthritis , 2011, Journal of Clinical Immunology.
[59] M. Grimm,et al. Glucocorticoid-induced TNFR family-related receptor (GITR)-expression in tumor infiltrating leucocytes (TILs) is associated with the pathogenesis of esophageal adenocarcinomas with and without Barrett's mucosa. , 2011, Cancer biomarkers : section A of Disease markers.
[60] Cong-hua Wang,et al. Combined Treatment of Etanercept and MTX Reverses Th1/Th2, Th17/Treg Imbalance in Patients with Rheumatoid Arthritis , 2011, Journal of Clinical Immunology.
[61] G. Ning,et al. Impairment of Regulatory Capacity of CD4+CD25+ Regulatory T Cells Mediated by Dendritic Cell Polarization and Hyperthyroidism in Graves’ Disease , 2011, The Journal of Immunology.
[62] M. Vatn,et al. Increase of regulatory T cells in ileal mucosa of untreated pediatric Crohn's disease patients , 2011, Scandinavian journal of gastroenterology.
[63] J. Myśliwska,et al. Lower Frequency of CD62Lhigh and Higher Frequency of TNFR2+ Tregs Are Associated with Inflammatory Conditions in Type 1 Diabetic Patients , 2011, Mediators of inflammation.
[64] B. Falini,et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. , 2011, Blood.
[65] S. Sakaguchi,et al. FOXP3+ regulatory T cells: control of FOXP3 expression by pharmacological agents. , 2011, Trends in pharmacological sciences.
[66] J. Wagner,et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. , 2011, Blood.
[67] Q. Ouyang,et al. Cutting Edge: Increased IL-17–Secreting T Cells in Children with New-Onset Type 1 Diabetes , 2010, The Journal of Immunology.
[68] S. Sakaguchi,et al. Regulatory T cells in tumor immunity , 2010, International journal of cancer.
[69] Loise M. Francisco,et al. The PD‐1 pathway in tolerance and autoimmunity , 2010, Immunological reviews.
[70] N. Rothman,et al. Risk of Meningioma and Common Variation in Genes Related to Innate Immunity , 2010, Cancer Epidemiology, Biomarkers & Prevention.
[71] T. Chatila,et al. GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells. , 2010, International immunology.
[72] Y. Belkaid,et al. Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells , 2010, The Journal of Immunology.
[73] Li Tang,et al. An isoleucine-zipper motif enhances costimulation of human soluble trimeric GITR ligand , 2010, Cellular and Molecular Immunology.
[74] H. Waldmann,et al. Enhancement of humoral and cellular immunity with an anti‐glucocorticoid‐induced tumour necrosis factor receptor monoclonal antibody , 2010, Immunology.
[75] J. Myśliwska,et al. First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells. , 2009, Clinical immunology.
[76] M. Gaub,et al. Diminution of Circulating CD4+CD25high T Cells in Naïve Crohn’s Disease , 2009, Digestive Diseases and Sciences.
[77] J. Bluestone,et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo , 2009, Nature Immunology.
[78] N. Müller,et al. Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor Ligand1 , 2009, The Journal of Immunology.
[79] M. Górska,et al. Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabetes. , 2009, Acta biochimica Polonica.
[80] L. Boon,et al. GITR Triggering Induces Expansion of Both Effector and Regulatory CD4+ T Cells In Vivo1 , 2009, The Journal of Immunology.
[81] J. Bluestone,et al. Plasticity of CD4(+) FoxP3(+) T cells. , 2009, Current opinion in immunology.
[82] K. Kawa,et al. The expression profile of functional regulatory T cells, CD4+CD25high+/forkhead box protein P3+, in patients with ulcerative colitis during active and quiescent disease , 2009, Clinical and experimental immunology.
[83] J. Mate,et al. Regulatory T cells in type 1 diabetic patients with autoimmune chronic atrophic gastritis , 2009, Endocrine.
[84] C. Riccardi,et al. Identification of regulatory T cells in systemic lupus erythematosus. , 2009, Autoimmunity reviews.
[85] J. Shimizu,et al. In vivo expansion of CD4+Foxp3+ regulatory T cells mediated by GITR molecules. , 2008, Immunology letters.
[86] M. Farrar,et al. IL-2, -7, and -15, but Not Thymic Stromal Lymphopoeitin, Redundantly Govern CD4+Foxp3+ Regulatory T Cell Development1 , 2008, The Journal of Immunology.
[87] H. Wiendl,et al. The role of regulatory T cells in multiple sclerosis , 2008, Nature Clinical Practice Neurology.
[88] C. Hsieh,et al. A two-step process for thymic regulatory T cell development. , 2008, Immunity.
[89] M. Farrar,et al. Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. , 2008, Immunity.
[90] E. Gambineri,et al. Role of regulatory T cells and FOXP3 in human diseases. , 2007, The Journal of allergy and clinical immunology.
[91] M. Battaglia,et al. Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans , 2007, Nature Reviews Immunology.
[92] W. Strober,et al. Cutting Edge: Regulatory T Cells Induce CD4+CD25−Foxp3− T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-β , 2007, The Journal of Immunology.
[93] S. Cuzzocrea,et al. GITR/GITRL: More than an effector T cell co‐stimulatory system , 2007, European journal of immunology.
[94] P. Lipsky,et al. Deficient CD4+CD25high T Regulatory Cell Function in Patients with Active Systemic Lupus Erythematosus1 , 2007, The Journal of Immunology.
[95] P. Emery,et al. Early rheumatoid arthritis is associated with a deficit in the CD4+CD25high regulatory T cell population in peripheral blood. , 2006, Rheumatology.
[96] J. Lifson,et al. Macaque Multimeric Soluble CD40 Ligand and GITR Ligand Constructs Are Immunostimulatory Molecules In Vitro , 2006, Clinical and Vaccine Immunology.
[97] W. Selby,et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells , 2006, The Journal of experimental medicine.
[98] C. Riccardi,et al. GITR modulates innate and adaptive mucosal immunity during the development of experimental colitis in mice , 2006, Gut.
[99] J. Shimizu,et al. Control of Autoimmune Myocarditis and Multiorgan Inflammation by Glucocorticoid-Induced TNF Receptor Family-Related Proteinhigh, Foxp3-Expressing CD25+ and CD25− Regulatory T Cells1 , 2006, The Journal of Immunology.
[100] M. Colombo,et al. Tumor-induced expansion of regulatory T cells by conversion of CD4+CD25- lymphocytes is thymus and proliferation independent. , 2006, Cancer research.
[101] M. Battaglia,et al. Tr1 cells: from discovery to their clinical application. , 2006, Seminars in immunology.
[102] J. Buer,et al. Inhibition of the Transcription Factor Foxp3 Converts Desmoglein 3-Specific Type 1 Regulatory T Cells into Th2-Like Cells1 , 2006, The Journal of Immunology.
[103] P. Debré,et al. The immune paradox of sarcoidosis and regulatory T cells , 2006, The Journal of experimental medicine.
[104] E. Mazzon,et al. Increased GILZ expression in transgenic mice up-regulates Th-2 lymphokines. , 2006, Blood.
[105] Gerd Ritter,et al. Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[106] T. Nomura,et al. Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells , 2005, The Journal of experimental medicine.
[107] E. Mazzon,et al. Role of glucocorticoid‐induced TNF receptor family gene (GITR) in collagen‐induced arthritis , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[108] Ethan M. Shevach,et al. Engagement of Glucocorticoid-Induced TNFR Family-Related Receptor on Effector T Cells by its Ligand Mediates Resistance to Suppression by CD4+CD25+ T Cells , 2004, The Journal of Immunology.
[109] Tetsuya Nakamura,et al. CD4+CD25bright T Cells in Human Intestinal Lamina Propria as Regulatory Cells1 , 2004, The Journal of Immunology.
[110] Jeffrey A. Bluestone,et al. In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes , 2004, The Journal of experimental medicine.
[111] W. Kuis,et al. CD4+CD25bright Regulatory T Cells Actively Regulate Inflammation in the Joints of Patients with the Remitting Form of Juvenile Idiopathic Arthritis , 2004, The Journal of Immunology.
[112] O. Lassila,et al. Phenotypic characterization of regulatory T cells in the human decidua , 2004, Clinical and experimental immunology.
[113] C. Riccardi,et al. Frontline: GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations , 2004, European journal of immunology.
[114] H. Waldmann,et al. Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[115] D. Bourdette,et al. Functional assay for human CD4+CD25+ Treg cells reveals an age‐dependent loss of suppressive activity , 2003, Journal of neuroscience research.
[116] Tetsuya Nakamura,et al. Regulation of Murine Inflammatory Bowel Disease by CD25+ and CD25− CD4+ Glucocorticoid-Induced TNF Receptor Family-Related Gene+ Regulatory T Cells1 , 2003, The Journal of Immunology.
[117] F. Ramsdell,et al. An essential role for Scurfin in CD4+CD25+ T regulatory cells , 2003, Nature Immunology.
[118] C. Riccardi,et al. GITR interacts with the pro-apoptotic protein Siva and induces apoptosis , 2002, Cell Death and Differentiation.
[119] Manuela Battaglia,et al. Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells , 2002, The Journal of experimental medicine.
[120] P. Pandolfi,et al. Role of GITR in activation response of T lymphocytes. , 2002, Blood.
[121] D. Zélénika,et al. Regulatory T Cells Overexpress a Subset of Th2 Gene Transcripts1 , 2002, The Journal of Immunology.
[122] J. Shimizu,et al. Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance , 2002, Nature Immunology.
[123] M. Byrne,et al. CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. , 2002, Immunity.
[124] M. Toda,et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. , 1995, Journal of immunology.
[125] J. Wang,et al. Increased apoptosis induction in CD4+ CD25+ Foxp3+ T cells contributes to enhanced disease activity in patients with rheumatoid arthritis through IL-10 regulation. , 2014, European review for medical and pharmacological sciences.
[126] J. Maher,et al. Use of gene-modified regulatory T-cells to control autoimmune and alloimmune pathology: is now the right time? , 2014, Clinical immunology.
[127] C. Riccardi,et al. GITR: a modulator of immune response and inflammation. , 2009, Advances in experimental medicine and biology.