DNA double-strand break repair pathway choice and cancer.

[1]  Michal Zimmermann,et al.  53BP1: pro choice in DNA repair. , 2014, Trends in cell biology.

[2]  John A Tainer,et al.  DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. , 2014, Molecular cell.

[3]  D. Roth,et al.  Modernizing the nonhomologous end-joining repertoire: alternative and classical NHEJ share the stage. , 2013, Annual review of genetics.

[4]  Rodney Rothstein,et al.  Repair of strand breaks by homologous recombination. , 2013, Cold Spring Harbor perspectives in biology.

[5]  M. Hickey Untangling BRCA mutations, sex hormones, and cancer risk. , 2013, The Lancet. Oncology.

[6]  R. Shoemaker,et al.  Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway. , 2013, Cancer research.

[7]  N. Gaikwad Metabolomic Profiling Unravels DNA Adducts in Human Breast That Are Formed from Peroxidase Mediated Activation of Estrogens to Quinone Methides , 2013, PloS one.

[8]  D. Ramsden,et al.  Trimming of damaged 3' overhangs of DNA double-strand breaks by the Metnase and Artemis endonucleases. , 2013, DNA repair.

[9]  Jeremy M. Stark,et al.  The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression , 2013, The Journal of cell biology.

[10]  L. Symington,et al.  RPA coordinates DNA end resection and prevents formation of DNA hairpins. , 2013, Molecular cell.

[11]  Chantal Stoepker,et al.  Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia. , 2013, American journal of human genetics.

[12]  A. Sartori,et al.  Controlling DNA-end resection: a new task for CDKs , 2013, Front. Genet..

[13]  Anabelle Decottignies,et al.  Alternative end-joining mechanisms: a historical perspective , 2013, Front. Genet..

[14]  T. Ludwig,et al.  Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase , 2013, Proceedings of the National Academy of Sciences.

[15]  Lin Feng,et al.  RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair* , 2013, The Journal of Biological Chemistry.

[16]  Facundo D. Batista,et al.  RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection , 2013, Molecular cell.

[17]  Adam P. Rosebrock,et al.  A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. , 2013, Molecular cell.

[18]  Michel C. Nussenzweig,et al.  Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching , 2013, Science.

[19]  S. B. Buonomo,et al.  53BP1 Regulates DSB Repair Using Rif1 to Control 5′ End Resection , 2013, Science.

[20]  Y. Pommier Drugging topoisomerases: lessons and challenges. , 2013, ACS chemical biology.

[21]  Molly C. Kottemann,et al.  Fanconi anaemia and the repair of Watson and Crick DNA crosslinks , 2013, Nature.

[22]  R. Greenberg,et al.  Links between genome integrity and BRCA1 tumor suppression. , 2012, Trends in biochemical sciences.

[23]  J. Doudna,et al.  A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , 2012, Science.

[24]  E. Meshorer,et al.  Live imaging of induced and controlled DNA double-strand break formation reveals extremely low repair by homologous recombination in human cells , 2012, Oncogene.

[25]  K. Khanna,et al.  Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions. , 2012, DNA repair.

[26]  Catherine L. Guay,et al.  Analysis of MRE11's function in the 5′→3′ processing of DNA double-strand breaks , 2012, Nucleic acids research.

[27]  P. Mckinnon ATM and the molecular pathogenesis of ataxia telangiectasia. , 2012, Annual review of pathology.

[28]  L. Symington,et al.  Double-strand break end resection and repair pathway choice. , 2011, Annual review of genetics.

[29]  T. Ludwig,et al.  BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity , 2011, Science.

[30]  B. Chait,et al.  Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair , 2011, The Journal of cell biology.

[31]  Steven S. Foster,et al.  Functional Interplay of the Mre11 Nuclease and Ku in the Response to Replication-Associated DNA Damage , 2011, Molecular and Cellular Biology.

[32]  Stephen C. West,et al.  DNA interstrand crosslink repair and cancer , 2011, Nature Reviews Cancer.

[33]  P. Sung,et al.  Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation , 2011, Nature Structural &Molecular Biology.

[34]  Markus Löbrich,et al.  Factors determining DNA double‐strand break repair pathway choice in G2 phase , 2011, The EMBO journal.

[35]  Paul Modrich,et al.  BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. , 2011, Genes & development.

[36]  Elo Leung,et al.  A TALE nuclease architecture for efficient genome editing , 2011, Nature Biotechnology.

[37]  N. Carter,et al.  Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development , 2011, Cell.

[38]  Yu Zhang,et al.  An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway , 2011, Nature Structural &Molecular Biology.

[39]  Stefano Ferrari,et al.  DNA end resection by CtIP and exonuclease 1 prevents genomic instability , 2010, EMBO reports.

[40]  Eleni P. Mimitou,et al.  Ku prevents Exo1 and Sgs1‐dependent resection of DNA ends in the absence of a functional MRX complex or Sae2 , 2010, The EMBO journal.

[41]  M. Sivasubramaniam,et al.  Ku70 Corrupts DNA Repair in the Absence of the Fanconi Anemia Pathway , 2010, Science.

[42]  Z. Hořejší,et al.  Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia. , 2010, Molecular cell.

[43]  M. Lieber,et al.  The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. , 2010, Annual review of biochemistry.

[44]  D. Adams,et al.  53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers , 2010, Nature Structural &Molecular Biology.

[45]  Jeremy M. Stark,et al.  53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks , 2010, Cell.

[46]  M. Jasin,et al.  Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis , 2010, Nature Reviews Molecular Cell Biology.

[47]  D. Ramsden,et al.  Ku is a 5'dRP/AP lyase that excises nucleotide damage near broken ends , 2010, Nature.

[48]  F. Alt,et al.  Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70 , 2010, Proceedings of the National Academy of Sciences.

[49]  Y. Pommier,et al.  Collaborative Action of Brca1 and CtIP in Elimination of Covalent Modifications from Double-Strand Breaks to Facilitate Subsequent Break Repair , 2010, PLoS genetics.

[50]  Michael S. Becker,et al.  The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers. , 2010, Advances in immunology.

[51]  A. Børresen-Dale,et al.  COMPLEX LANDSCAPES OF SOMATIC REARRANGEMENT IN HUMAN BREAST CANCER GENOMES , 2009, Nature.

[52]  S. Elledge,et al.  The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair , 2009, Science.

[53]  J. Hoeijmakers DNA damage, aging, and cancer. , 2009, The New England journal of medicine.

[54]  Sang Eun Lee,et al.  Regulation of repair choice: Cdk1 suppresses recruitment of end joining factors at DNA breaks. , 2009, DNA repair.

[55]  Nicole Bennardo,et al.  Limiting the Persistence of a Chromosome Break Diminishes Its Mutagenic Potential , 2009, PLoS genetics.

[56]  K. Caldecott,et al.  A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage , 2009, Nature.

[57]  C. Deng,et al.  A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. , 2009, Molecular cell.

[58]  Jean Gautier,et al.  Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells , 2009, Nature Structural &Molecular Biology.

[59]  Stephen P. Jackson,et al.  Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair*S⃞ , 2009, Journal of Biological Chemistry.

[60]  Maximina H. Yun,et al.  CtIP-BRCA1 modulates the choice of DNA double-strand break repair pathway throughout the cell cycle , 2009, Nature.

[61]  M. J. Neale,et al.  Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA. , 2009, Molecular cell.

[62]  J. Gautier,et al.  Fanconi anemia proteins stabilize replication forks. , 2008, DNA repair.

[63]  S. Jackson,et al.  CDK targets Sae2 to control DNA-end resection and homologous recombination , 2008, Nature.

[64]  J. Jonkers,et al.  Mouse models for BRCA1 associated tumorigenesis: From fundamental insights to preclinical utility , 2008, Cell cycle.

[65]  G. Lucchini,et al.  The Yku70–Yku80 complex contributes to regulate double‐strand break processing and checkpoint activation during the cell cycle , 2008, EMBO reports.

[66]  Jeremy M. Stark,et al.  Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair , 2008, PLoS genetics.

[67]  R. Rothstein,et al.  Differential regulation of the cellular response to DNA double-strand breaks in G1. , 2008, Molecular cell.

[68]  Xiaohua Wu,et al.  Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair* , 2008, Journal of Biological Chemistry.

[69]  T. E. Wilson,et al.  Recruitment and Dissociation of Nonhomologous End Joining Proteins at a DNA Double-Strand Break in Saccharomyces cerevisiae , 2008, Genetics.

[70]  Jean Gautier,et al.  A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. , 2008, Nature chemical biology.

[71]  S. Nakajima,et al.  A novel human AP endonuclease with conserved zinc‐finger‐like motifs involved in DNA strand break responses , 2007, The EMBO journal.

[72]  Xin Wang,et al.  A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. , 2007, Molecular cell.

[73]  S. West,et al.  The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates , 2006, Nature.

[74]  M. Lieber,et al.  Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocations. , 2006, DNA repair.

[75]  L. Thompson,et al.  The Fanconi anemia pathway limits the severity of mutagenesis. , 2006, DNA repair.

[76]  Rafael Núñez,et al.  BRCA1 promotes induction of ssDNA by ionizing radiation. , 2006, Cancer research.

[77]  W. Foulkes,et al.  The basal phenotype of BRCA1-related breast cancer: past, present and future. , 2006, Cell cycle.

[78]  D. Weinstock,et al.  Alternative Pathways for the Repair of RAG-Induced DNA Breaks , 2006, Molecular and Cellular Biology.

[79]  M. J. Neale,et al.  Endonucleolytic processing of covalent protein-linked DNA double-strand breaks , 2005, Nature.

[80]  Jeffrey C. Miller,et al.  Highly efficient endogenous human gene correction using designed zinc-finger nucleases , 2005, Nature.

[81]  M. Kupiec,et al.  The CDK regulates repair of double‐strand breaks by homologous recombination during the cell cycle , 2004, The EMBO journal.

[82]  Marco Foiani,et al.  DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1 , 2004, Nature.

[83]  R. Wooster,et al.  Breast and ovarian cancer. , 2003, The New England journal of medicine.

[84]  M. Frank-Vaillant,et al.  Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination. , 2002, Molecular cell.

[85]  Yunmei Ma,et al.  Hairpin Opening and Overhang Processing by an Artemis/DNA-Dependent Protein Kinase Complex in Nonhomologous End Joining and V(D)J Recombination , 2002, Cell.

[86]  N. Ellis,et al.  Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. , 2001, Genes & development.

[87]  C. Campbell,et al.  Deficient DNA End Joining Activity in Extracts from Fanconi Anemia Fibroblasts* , 2001, The Journal of Biological Chemistry.

[88]  Rachel L. Allen,et al.  Defying death after DNA damage , 2000, Nature.

[89]  F. Alt,et al.  The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[90]  J. Pouliot,et al.  Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes. , 1999, Science.

[91]  S. Scherer,et al.  Molecular Cloning of the Human Gene, PNKP, Encoding a Polynucleotide Kinase 3′-Phosphatase and Evidence for Its Role in Repair of DNA Strand Breaks Caused by Oxidative Damage* , 1999, The Journal of Biological Chemistry.

[92]  W. Dynan,et al.  Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids. , 1998, Nucleic acids research.

[93]  M. Jasin,et al.  Genetic manipulation of genomes with rare-cutting endonucleases. , 1996, Trends in genetics : TIG.

[94]  J. Haber,et al.  Efficient repair of HO-induced chromosomal breaks in Saccharomyces cerevisiae by recombination between flanking homologous sequences , 1988, Molecular and cellular biology.

[95]  B. Dujon,et al.  Recognition and cleavage site of the intron-encoded omega transposase. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[96]  J A Hardin,et al.  Mechanism of interaction between Ku protein and DNA. , 1986, The Journal of biological chemistry.

[97]  J. Garland The New England Journal of Medicine. , 1961, Canadian Medical Association journal.