Evaluation of radixact motion synchrony for 3D respiratory motion: Modeling accuracy and dosimetric fidelity

Abstract The Radixact® linear accelerator contains the motion Synchrony system, which tracks and compensates for intrafraction patient motion. For respiratory motion, the system models the motion of the target and synchronizes the delivery of radiation with this motion using the jaws and multi‐leaf collimators (MLCs). It was the purpose of this work to determine the ability of the Synchrony system to track and compensate for different phantom motions using a delivery quality assurance (DQA) workflow. Thirteen helical plans were created on static datasets from liver, lung, and pancreas subjects. Dose distributions were measured using a Delta4® Phantom+ mounted on a Hexamotion® stage for the following three case scenarios for each plan: (a) no phantom motion and no Synchrony (M0S0), (b) phantom motion and no Synchrony (M1S0), and (c) phantom motion with Synchrony (M1S1). The LEDs were placed on the Phantom+ for the 13 patient cases and were placed on a separate one‐dimensional surrogate stage for additional studies to investigate the effect of separate target and surrogate motion. The root‐mean‐square (RMS) error between the Synchrony‐modeled positions and the programmed phantom positions was <1.5 mm for all Synchrony deliveries with the LEDs on the Phantom+. The tracking errors increased slightly when the LEDs were placed on the surrogate stage but were similar to tracking errors observed for other motion tracking systems such as CyberKnife Synchrony. One‐dimensional profiles indicate the effects of motion interplay and dose blurring present in several of the M1S0 plans that are not present in the M1S1 plans. All 13 of the M1S1 measured doses had gamma pass rates (3%/2 mm/10%T) compared to the planned dose > 90%. Only two of the M1S0 measured doses had gamma pass rates > 90%. Motion Synchrony offers a potential alternative to the current, ITV‐based motion management strategy for helical tomotherapy deliveries.

[1]  H. Shiomi,et al.  Impacts of respiratory phase shifts on motion-tracking accuracy of the CyberKnife Synchrony™ Respiratory Tracking System. , 2019, Medical physics.

[2]  K. Langen,et al.  Organ motion and its management. , 2001, International journal of radiation oncology, biology, physics.

[3]  Marcel van Herk,et al.  Errors and margins in radiotherapy. , 2004, Seminars in radiation oncology.

[4]  Ping Xia,et al.  Tolerance limits and methodologies for IMRT measurement‐based verification QA , 2018, Medical physics.

[5]  J. Chavaudra,et al.  Prescribing, Recording, And Reporting Photon Beam Therapy Presentation Of The ICRU Report # 50 , 1992 .

[6]  Hiroki Shirato,et al.  Accuracy of tumor motion compensation algorithm from a robotic respiratory tracking system: a simulation study. , 2007, Medical physics.

[7]  E. Larsen,et al.  A method for incorporating organ motion due to breathing into 3D dose calculations. , 1999, Medical physics.

[8]  M. V. van Herk,et al.  Precise and real-time measurement of 3D tumor motion in lung due to breathing and heartbeat, measured during radiotherapy. , 2002, International journal of radiation oncology, biology, physics.

[9]  Robert Jeraj,et al.  On the impact of longitudinal breathing motion randomness for tomotherapy delivery , 2008, Physics in medicine and biology.

[10]  J. McClelland,et al.  Assessment of two novel ventilatory surrogates for use in the delivery of gated/tracked radiotherapy for non-small cell lung cancer. , 2009, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[11]  J O Deasy,et al.  Tomotherapy: a new concept for the delivery of dynamic conformal radiotherapy. , 1993, Medical physics.

[12]  J. Adler,et al.  Robotic Motion Compensation for Respiratory Movement during Radiosurgery , 2000, Computer aided surgery : official journal of the International Society for Computer Aided Surgery.

[13]  D. Low,et al.  Dosimetric variances anticipated from breathing- induced tumor motion during tomotherapy treatment delivery , 2009, Physics in medicine and biology.

[14]  Robert Jeraj,et al.  Confirmation, refinement, and extension of a study in intrafraction motion interplay with sliding jaw motion. , 2005, Medical physics.

[15]  K. Sheng,et al.  The implication of non-cyclic intrafractional longitudinal motion in SBRT by TomoTherapy , 2009, Physics in medicine and biology.

[16]  Steve B. Jiang,et al.  The management of respiratory motion in radiation oncology report of AAPM Task Group 76. , 2006, Medical physics.

[17]  Steve B. Jiang,et al.  Effects of intra-fraction motion on IMRT dose delivery: statistical analysis and simulation. , 2002, Physics in medicine and biology.

[18]  Andriy Myronenko,et al.  Feasibility of real‐time motion management with helical tomotherapy , 2018, Medical Physics (Lancaster).

[19]  S. Harden,et al.  Three-dimensional analysis of the respiratory interplay effect in helical tomotherapy: Baseline variations cause the greater part of dose inhomogeneities seen. , 2014, Medical physics.

[20]  E. Chao,et al.  Evaluation of TomoTherapy dose calculations with intrafractional motion and motion compensation , 2018, Medical physics.

[21]  S. Korreman Motion in radiotherapy: photon therapy , 2012, Physics in medicine and biology.

[22]  Sasa Mutic,et al.  The ViewRay system: magnetic resonance-guided and controlled radiotherapy. , 2014, Seminars in radiation oncology.

[23]  X. Li,et al.  Technical Note: Comprehensive performance tests of the first clinical real‐time motion tracking and compensation system using MLC and jaws , 2020, Medical physics.

[24]  Tomio Inoue,et al.  Development of system using beam's eye view images to measure respiratory motion tracking errors in image‐guided robotic radiosurgery system , 2015, Journal of applied clinical medical physics.

[25]  Ying Xiao,et al.  Motion management strategies and technical issues associated with stereotactic body radiotherapy of thoracic and upper abdominal tumors: A review from NRG oncology , 2017, Medical physics.

[26]  Melvin L. Griem,et al.  Prescribing, Recording, and Reporting Photon Beam Therapy , 1994 .