EVALUATION OF ESSENTIAL OIL OF Myrtus communis LEAVES FOR ANALGESIC AND GISTROINTESTINAL MOTILITY PROFILE

Summary In the present research work the essential oil of Myrtus communis Leaves were tested for their analgesic and gastrointestinal motility. The analgesic effect was evaluated in mice, using acetic acid induced writhing test and effect on GIT motility was also tested in mice using charcoal as marker in intestine. The essential oils showed dose dependent analgesic effect in compression with standard drug and significantly (P<0.05) inhibited the writhing at 100 and 150 mg/kg, while the analgesic effect was non-significant at the dose of 50 mg/kg. In case of GIT motility the oils were good laxative at low dose (50 mg/kg) while with increasing the dose the motility was not significant. It can be concluded that the oils should be use for constipation in low dose while for analgesic effect its high dose is required.

[1]  Barkatullah,et al.  Pharmacognostic studies of Viola betonicifolia , 2012 .

[2]  M. Saeed,et al.  Biological screening of Viola betonicifolia Smith whole plant , 2011 .

[3]  Shafiqur Rahman,et al.  Correlation of the antioxidant capacity with the phenolic contents of Hypericum monogynum and Hypericum perforatum , 2011 .

[4]  B. Barkatullah.  Evaluation of Zanthoxylum armatum DC for in-vitro and in-vivo pharmacological screening , 2011 .

[5]  N. Muhammad,et al.  Antibacetial screening of leaves and stem of Carica papaya , 2011 .

[6]  Barkatullah,et al.  Pharmacognostic and phytochemical investigation of the stem bark of Pistacia integerrima Stew ex Brandis , 2011 .

[7]  S. Cannas,et al.  Evaluation of the Antimicrobial Properties of the Essential Oil of Myrtus communis L. against Clinical Strains of Mycobacterium spp. , 2010, Interdisciplinary perspectives on infectious diseases.

[8]  E. Solá,et al.  Oxidative stress, endothelial dysfunction and atherosclerosis. , 2009, Current pharmaceutical design.

[9]  Achinto Saha,et al.  BIOACTIVE ALKALOID FROM SIDA CORDIFOLIA LINN. WITH ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES , 2006 .

[10]  V. Butterweck,et al.  Flavonoids of St. John's Wort reduce HPA axis function in the rat. , 2004, Planta medica.

[11]  M. Lucchesi,et al.  Protocol to refine intestinal motility test in mice , 2004, Laboratory animals.

[12]  G. Flamini,et al.  Phytochemical typologies in some populations of Myrtus communis L. on Caprione Promontory (East Liguria, Italy) , 2004 .

[13]  H. Khan,et al.  Evaluation of n-hexane extract of Viola betonicifolia for its neuropharmacological properties , 2012, Journal of Natural Medicines.

[14]  N. Muhammad,et al.  Evaluation of the stem bark of Pistacia integerrima Stew ex Brandis for its antimicrobial and phytotoxic activities , 2011 .

[15]  N. Ilyas,et al.  Evaluation of analgesic and anti-inflammatory activities of n-butanol phase of the leaves extract of Microtrichia perotitii DC (Asteraceae) , 2010 .

[16]  G. Flamini,et al.  Essential oil of Teucrium scorodonia L. ssp. scorodonia from Italy , 2007 .