Prophylactic Hepatitis E Vaccine.

[1]  M. Khuroo,et al.  Hepatitis E: an emerging global disease – from discovery towards control and cure , 2016, Journal of viral hepatitis.

[2]  N. Xia,et al.  Modeling the long-term antibody response of a hepatitis E vaccine. , 2015, Vaccine.

[3]  Qinjian Zhao,et al.  Comparable quality attributes of hepatitis E vaccine antigen with and without adjuvant adsorption-dissolution treatment , 2015, Human vaccines & immunotherapeutics.

[4]  S. Sauleda,et al.  Seroprevalence of hepatitis E virus (HEV) and detection of HEV RNA with a transcription‐mediated amplification assay in blood donors from Catalonia (Spain) , 2015, Transfusion.

[5]  C. Hew,et al.  Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody , 2015, Cell Research.

[6]  N. Xia,et al.  Long-term efficacy of a hepatitis E vaccine. , 2015, The New England journal of medicine.

[7]  J. Ward,et al.  Making hepatitis E a vaccine-preventable disease. , 2015, The New England journal of medicine.

[8]  Qinjian Zhao,et al.  The development of a recombinant hepatitis E vaccine HEV 239 , 2015, Human vaccines & immunotherapeutics.

[9]  K. Nelson,et al.  Risk factors for hepatitis E virus infection and disease , 2015, Expert review of anti-infective therapy.

[10]  Zizheng Zheng,et al.  A Valuable Antigen Detection Method for Diagnosis of Acute Hepatitis E , 2014, Journal of Clinical Microbiology.

[11]  I. Ushiro-Lumb,et al.  Hepatitis E virus in blood components: a prevalence and transmission study in southeast England , 2014, The Lancet.

[12]  P. Gallian,et al.  Hepatitis E Virus Infections in Blood Donors, France , 2014, Emerging infectious diseases.

[13]  Yanjin Zhang,et al.  Hepatitis E Virus Inhibits Type I Interferon Induction by ORF1 Products , 2014, Journal of Virology.

[14]  Qinjian Zhao,et al.  Robust manufacturing and comprehensive characterization of recombinant hepatitis E virus-like particles in Hecolin(®). , 2014, Vaccine.

[15]  L. Rostaing,et al.  Hepatitis E virus reinfections in solid-organ-transplant recipients can evolve into chronic infections. , 2014, The Journal of infectious diseases.

[16]  Qinjian Zhao,et al.  Bacteria expressed hepatitis E virus capsid proteins maintain virion-like epitopes. , 2014, Vaccine.

[17]  N. Xia,et al.  Epidemiology of Zoonotic Hepatitis E: A Community-Based Surveillance Study in a Rural Population in China , 2014, PloS one.

[18]  J. Pawlotsky,et al.  Should we screen blood products for hepatitis E virus RNA ? , 2014, The Lancet.

[19]  N. Xia,et al.  Hepatitis E virus capsid protein assembles in 4M urea in the presence of salts , 2013, Protein science : a publication of the Protein Society.

[20]  Soo-bin Park Hepatitis E vaccine debuts , 2012, Nature.

[21]  K. Nelson,et al.  Hepatitis E, a Vaccine-Preventable Cause of Maternal Deaths , 2012, Emerging infectious diseases.

[22]  Qinjian Zhao,et al.  Hepatitis E virus: neutralizing sites, diagnosis, and protective immunity , 2012, Reviews in medical virology.

[23]  Qinjian Zhao,et al.  Hepatitis E vaccine development , 2012, Human vaccines & immunotherapeutics.

[24]  N. Xia,et al.  Safety of the hepatitis E vaccine for pregnant women: A preliminary analysis , 2012, Hepatology.

[25]  M. Koopmans,et al.  Hepatitis E Virus Infection among Solid Organ Transplant Recipients, the Netherlands , 2012, Emerging infectious diseases.

[26]  M. Manns,et al.  Pathogenesis and treatment of hepatitis e virus infection. , 2012, Gastroenterology.

[27]  B. Schlosser,et al.  Liver transplant from a donor with occult HEV infection induced chronic hepatitis and cirrhosis in the recipient. , 2012, Journal of hepatology.

[28]  F. Alvarez,et al.  Chronic hepatitis E infection in children with liver transplantation , 2011, Gut.

[29]  K. Krawczyński,et al.  Pathogenetic elements of hepatitis E and animal models of HEV infection. , 2011, Virus research.

[30]  Yao-Wei Huang,et al.  Prior infection of pigs with a genotype 3 swine hepatitis E virus (HEV) protects against subsequent challenges with homologous and heterologous genotypes 3 and 4 human HEV. , 2011, Virus research.

[31]  C. Hew,et al.  Structural basis for the neutralization and genotype specificity of hepatitis E virus , 2011, Proceedings of the National Academy of Sciences.

[32]  J. Dumortier,et al.  Factors associated with chronic hepatitis in patients with hepatitis E virus infection who have received solid organ transplants. , 2011, Gastroenterology.

[33]  J. Torresi,et al.  Hepatitis A and E Infection in International Travellers , 2011, Current infectious disease reports.

[34]  L. Xing,et al.  Spatial Configuration of Hepatitis E Virus Antigenic Domain , 2010, Journal of Virology.

[35]  N. Xia,et al.  Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial , 2010, The Lancet.

[36]  L. Xing,et al.  Structure of Hepatitis E Virion-sized Particle Reveals an RNA-dependent Viral Assembly Pathway* , 2010, The Journal of Biological Chemistry.

[37]  J. Ward,et al.  Hepatitis E Epidemic, Uganda , 2010, Emerging infectious diseases.

[38]  M. Manns,et al.  Hepatitis E virus infection as a cause of graft hepatitis in liver transplant recipients , 2010, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[39]  H. Vennema,et al.  Prevalence of hepatitis E virus infection in liver transplant recipients , 2009, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[40]  Y. Tao,et al.  Structure of the hepatitis E virus-like particle suggests mechanisms for virus assembly and receptor binding , 2009, Proceedings of the National Academy of Sciences.

[41]  T. Tsukihara,et al.  Biological and immunological characteristics of hepatitis E virus-like particles based on the crystal structure , 2009, Proceedings of the National Academy of Sciences.

[42]  J. Seetharaman,et al.  Dimerization of Hepatitis E Virus Capsid Protein E2s Domain Is Essential for Virus–Host Interaction , 2009, PLoS pathogens.

[43]  Toshinori Tanaka,et al.  ORF3 protein of hepatitis E virus is essential for virion release from infected cells. , 2009, The Journal of general virology.

[44]  J. Meng,et al.  Characterization of antigenic epitopes of the ORF2 protein from hepatitis E virus genotype 4. , 2009, Virus research.

[45]  N. Xia,et al.  Randomized-controlled phase II clinical trial of a bacterially expressed recombinant hepatitis E vaccine. , 2009, Vaccine.

[46]  T. Harrison,et al.  Immunogenicity and protective efficacy in rhesus monkeys of a recombinant ORF2 protein from hepatitis E virus genotype 4 , 2009, Archives of Virology.

[47]  Youchun Wang,et al.  Cross‐protection of hepatitis E virus genotypes 1 and 4 in rhesus macaques , 2008, Journal of medical virology.

[48]  Harry Vennema,et al.  Chronic hepatitis E virus infection in liver transplant recipients , 2008, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[49]  P. Colson,et al.  Chronic hepatitis E with cirrhosis in a kidney-transplant recipient. , 2008, The New England journal of medicine.

[50]  S. Sarin,et al.  Maternal and Fetal Outcomes in Pregnant Women with Acute Hepatitis E Virus Infection , 2007, Annals of Internal Medicine.

[51]  N. Xia,et al.  Difference of T cell and B cell activation in two homologous proteins with similar antigenicity but great distinct immunogenicity. , 2007, Molecular immunology.

[52]  D. Vaughn,et al.  Safety and efficacy of a recombinant hepatitis E vaccine. , 2007, The New England journal of medicine.

[53]  K. Madan,et al.  Hepatitis E virus (HEV) infection in patients with cirrhosis is associated with rapid decompensation and death. , 2007, Journal of hepatology.

[54]  J. Guthmann,et al.  High mortality associated with an outbreak of hepatitis E among displaced persons in Darfur, Sudan. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[55]  S. Emerson,et al.  Putative neutralization epitopes and broad cross-genotype neutralization of Hepatitis E virus confirmed by a quantitative cell-culture assay. , 2006, The Journal of general virology.

[56]  L. Xing,et al.  Essential Elements of the Capsid Protein for Self-Assembly into Empty Virus-Like Particles of Hepatitis E Virus , 2005, Journal of Virology.

[57]  H. Dalton,et al.  Non-travel-associated hepatitis E in England and Wales: demographic, clinical, and molecular epidemiological characteristics. , 2005, The Journal of infectious diseases.

[58]  S. Emerson,et al.  A truncated ORF2 protein contains the most immunogenic site on ORF2: antibody responses to non-vaccine sequences following challenge of vaccinated and non-vaccinated macaques with hepatitis E virus. , 2005, Vaccine.

[59]  N. Xia,et al.  A bacterially expressed particulate hepatitis E vaccine: antigenicity, immunogenicity and protectivity on primates. , 2005, Vaccine.

[60]  Jun Zhang,et al.  Analysis of hepatitis E virus neutralization sites using monoclonal antibodies directed against a virus capsid protein. , 2005, Vaccine.

[61]  N. Xia,et al.  Mutational Analysis of Essential Interactions Involved in the Assembly of Hepatitis E Virus Capsid* , 2005, Journal of Biological Chemistry.

[62]  N. S. Murthy,et al.  Hepatitis E in pregnancy , 2004 .

[63]  G. Kang,et al.  Hepatitis E superinfection produces severe decompensation in patients with chronic liver disease , 2004, Journal of gastroenterology and hepatology.

[64]  N. Xia,et al.  Evaluation of antibody‐based and nucleic acid‐based assays for diagnosis of hepatitis E virus infection in a rhesus monkey model , 2003, Journal of medical virology.

[65]  M. Shapiro,et al.  Pre-clinical immunogenicity and efficacy trial of a recombinant hepatitis E vaccine. , 2003, Vaccine.

[66]  N. Xia,et al.  [The immuno-protect study of a hepatitis E virus ORF2 peptide expressed in E. coli]. , 2003, Wei sheng wu xue bao = Acta microbiologica Sinica.

[67]  S. Emerson,et al.  Hepatitis E Virus (HEV) Capsid Antigens Derived from Viruses of Human and Swine Origin Are Equally Efficient for Detecting Anti-HEV by Enzyme Immunoassay , 2002, Journal of Clinical Microbiology.

[68]  S. Emerson,et al.  Recombinant vaccine against hepatitis E: duration of protective immunity in rhesus macaques. , 2002, Vaccine.

[69]  S. Hamid,et al.  Hepatitis E virus superinfection in patients with chronic liver disease , 2002, Hepatology.

[70]  S. Emerson,et al.  Immunogenicity and protective efficacy of a vaccine prepared from 53 kDa truncated hepatitis E virus capsid protein expressed in insect cells. , 2001, Vaccine.

[71]  J. Meng,et al.  Identification and characterization of the neutralization epitope(s) of the hepatitis E virus. , 2001, Virology.

[72]  N. Xia,et al.  Conformational antigenic determinants generated by interactions between a bacterially expressed recombinant peptide of the hepatitis E virus structural protein , 2001, Journal of medical virology.

[73]  A. Safary Perspectives of Vaccination against Hepatitis E , 2001, Intervirology.

[74]  S. Emerson,et al.  Identification by Phage Display and Characterization of Two Neutralizing Chimpanzee Monoclonal Antibodies to the Hepatitis E Virus Capsid Protein , 2000, Journal of Virology.

[75]  L. Xing,et al.  Recombinant hepatitis E capsid protein self-assembles into a dual-domain T = 1 particle presenting native virus epitopes. , 1999, Virology.

[76]  Y. Khudyakov,et al.  Antigenic Domains of the Open Reading Frame 2-Encoded Protein of Hepatitis E Virus , 1999, Journal of Clinical Microbiology.

[77]  V. Arankalle,et al.  Long-term serological follow up and cross-challenge studies in rhesus monkeys experimentally infected with hepatitis E virus. , 1999, Journal of hepatology.

[78]  J. Meng,et al.  Neutralization of different geographic strains of the hepatitis E virus with anti-hepatitis E virus-positive serum samples obtained from different sources. , 1998, Virology.

[79]  S. Emerson,et al.  Structural characterization of recombinant hepatitis E virus ORF2 proteins in baculovirus-infected insect cells. , 1998, Protein expression and purification.

[80]  M. Shapiro,et al.  Recombinant vaccine against hepatitis E: dose response and protection against heterologous challenge. , 1997, Vaccine.

[81]  T. Miyamura,et al.  Expression and self-assembly of empty virus-like particles of hepatitis E virus , 1997, Journal of virology.

[82]  S. Locarnini,et al.  Amino‐terminal epitopes are exposed when full‐length open reading frame 2 of hepatitis E virus is expressed in Escherichia coli, but carboxy‐terminal epitopes are masked , 1997, Journal of medical virology.

[83]  Z. Abbas,et al.  Fulminant hepatic failure in pregnant women: acute fatty liver or acute viral hepatitis? , 1996, Journal of hepatology.

[84]  V. Arankalle,et al.  Cross‐challenge studies in rhesus monkeys employing different Indian isolates of hepatitis E virus , 1995, Journal of medical virology.

[85]  M. Shapiro,et al.  Successful passive and active immunization of cynomolgus monkeys against hepatitis E. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[86]  S. Emerson,et al.  Epidemic hepatitis E in Pakistan: patterns of serologic response and evidence that antibody to hepatitis E virus protects against disease. , 1994, The Journal of infectious diseases.

[87]  V. Arankalle,et al.  Rhesus monkeys infected with hepatitis E virus (HEV) from the former USSR are immune to subsequent challenge with an Indian strain of HEV. , 1993, Acta virologica.

[88]  D. Bradley,et al.  Preliminary evidence that a trpE‐HEV fusion protein protects cynomolgus macaques against challenge with wild‐type hepatitis e virus (HEV) , 1993, Journal of medical virology.

[89]  S. Emerson,et al.  ELISA for antibody to hepatitis E virus (HEV) based on complete open-reading frame-2 protein expressed in insect cells: identification of HEV infection in primates. , 1993, The Journal of infectious diseases.

[90]  B. Robertson,et al.  A broadly reactive one-step real-time RT-PCR assay for rapid and sensitive detection of hepatitis E virus. , 2006, Journal of virological methods.

[91]  M. Favorov,et al.  Immunodominant antigenic regions in a structural protein of the hepatitis E virus. , 1994, Virology.