Probing the metabolic phenotype of breast cancer cells by multiple tracer stable isotope resolved metabolomics.

[1]  Andrew N Lane,et al.  Applications of NMR spectroscopy to systems biochemistry. , 2016, Progress in nuclear magnetic resonance spectroscopy.

[2]  Giuseppe Merlino,et al.  Tumor-extracellular matrix interactions: Identification of tools associated with breast cancer progression. , 2015, Seminars in cancer biology.

[3]  A. Lane,et al.  13C Tracer Studies of Metabolism in Mouse Tumor Xenografts. , 2015, Bio-protocol.

[4]  J. Wallace,et al.  Pyruvate Carboxylase Is Up-Regulated in Breast Cancer and Essential to Support Growth and Invasion of MDA-MB-231 Cells , 2015, PloS one.

[5]  A. Lane,et al.  Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation. , 2015, The Journal of clinical investigation.

[6]  A. Lane,et al.  Regulation of mammalian nucleotide metabolism and biosynthesis , 2015, Nucleic acids research.

[7]  J. Swinnen,et al.  Cancer Cells Differentially Activate and Thrive on De Novo Lipid Synthesis Pathways in a Low-Lipid Environment , 2014, PloS one.

[8]  K. Vousden,et al.  Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells. , 2014, Cell reports.

[9]  Z. Oltvai,et al.  The metabolic demands of cancer cells are coupled to their size and protein synthesis rates , 2013, Cancer & metabolism.

[10]  A. Lane,et al.  Metabolic Reprogramming for Producing Energy and Reducing Power in Fumarate Hydratase Null Cells from Hereditary Leiomyomatosis Renal Cell Carcinoma , 2013, PloS one.

[11]  J. Locasale Serine, glycine and one-carbon units: cancer metabolism in full circle , 2013, Nature Reviews Cancer.

[12]  E. White,et al.  Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids , 2013, Proceedings of the National Academy of Sciences.

[13]  Jun Yao,et al.  Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. , 2013, Cancer cell.

[14]  R. B. Azevedo,et al.  On the Immortality of Television Sets: “Function” in the Human Genome According to the Evolution-Free Gospel of ENCODE , 2013, Genome biology and evolution.

[15]  R. Díaz-Ruíz,et al.  Anaplerosis in cancer: Another step beyond the warburg effect , 2012 .

[16]  R. Deberardinis,et al.  Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors , 2012, NMR in biomedicine.

[17]  R. Deberardinis,et al.  Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. , 2012, Cell metabolism.

[18]  A. Lane,et al.  Stable isotope resolved metabolomics analysis of ribonucleotide and RNA metabolism in human lung cancer cells , 2012, Metabolomics.

[19]  V. Mootha,et al.  Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation , 2012, Science.

[20]  Wei Liu,et al.  Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC , 2012, Proceedings of the National Academy of Sciences.

[21]  A. Børresen-Dale,et al.  The landscape of cancer genes and mutational processes in breast cancer , 2012, Nature.

[22]  Gerald C. Chu,et al.  Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism , 2012, Cell.

[23]  T. Fan,et al.  The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. , 2012, Cell metabolism.

[24]  Takashi Tsukamoto,et al.  Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. , 2012, Cell metabolism.

[25]  Christian M. Metallo,et al.  Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia , 2011, Nature.

[26]  W. Marston Linehan,et al.  Reductive carboxylation supports growth in tumor cells with defective mitochondria , 2011, Nature.

[27]  Gabriela Kalna,et al.  Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase , 2011, Nature.

[28]  C. Dang,et al.  Otto Warburg's contributions to current concepts of cancer metabolism , 2011, Nature Reviews Cancer.

[29]  A. Lane,et al.  Stable isotope resolved metabolomics of lung cancer in a SCID mouse model , 2011, Metabolomics.

[30]  A. Lane,et al.  A novel deconvolution method for modeling UDP-N-acetyl-D-glucosamine biosynthetic pathways based on 13C mass isotopologue profiles under non-steady-state conditions , 2011, BMC Biology.

[31]  A. Lane,et al.  Stable isotope-resolved metabolomics (SIRM) in cancer research with clinical application to nonsmall cell lung cancer. , 2011, Omics : a journal of integrative biology.

[32]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[33]  M. Holl,et al.  Direct measurement of oxygen consumption rates from attached and unattached cells in a reversibly sealed, diffusionally isolated sample chamber. , 2010, Advances in bioscience and biotechnology.

[34]  W. Linehan,et al.  The genetic basis of kidney cancer: a metabolic disease , 2010, Nature Reviews Urology.

[35]  W. Wheaton,et al.  Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity , 2010, Proceedings of the National Academy of Sciences.

[36]  Sten Orrenius,et al.  The Warburg effect and mitochondrial stability in cancer cells. , 2010, Molecular aspects of medicine.

[37]  R. Deberardinis,et al.  Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer , 2010, Oncogene.

[38]  H. Moseley,et al.  Isotopomer analysis of lipid biosynthesis by high resolution mass spectrometry and NMR. , 2009, Analytica chimica acta.

[39]  T. Fan,et al.  Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM) , 2009, Molecular Cancer.

[40]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[41]  J. Klawitter,et al.  Abnormalities in Glucose Uptake and Metabolism in Imatinib-Resistant Human BCR-ABL–Positive Cells , 2009, Clinical Cancer Research.

[42]  T. Fan,et al.  Rhabdomyosarcoma cells show an energy producing anabolic metabolic phenotype compared with primary myocytes , 2008, Molecular Cancer.

[43]  Andrew N. Lane,et al.  Structure-based profiling of metabolites and isotopomers by NMR , 2008 .

[44]  J. Brunet,et al.  Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells , 2008, Cell proliferation.

[45]  A. Lane,et al.  The oncoprotein H-RasV12 increases mitochondrial metabolism , 2007, Molecular Cancer.

[46]  R. Gillies,et al.  Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis? , 2007, Journal of bioenergetics and biomembranes.

[47]  C. Hudis Trastuzumab--mechanism of action and use in clinical practice. , 2007, The New England journal of medicine.

[48]  Nicola Zamboni,et al.  Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells , 2007, The Journal of cell biology.

[49]  M. Cascante,et al.  Metabolic profile and quantification of deoxyribose synthesis pathways in HepG2 cells , 2007, Metabolomics.

[50]  Andrew N. Lane,et al.  Quantification and identification of isotopomer distributions of metabolites in crude cell extracts using 1H TOCSY , 2007, Metabolomics.

[51]  J. Swinnen,et al.  Increased lipogenesis in cancer cells: new players, novel targets , 2006, Current opinion in clinical nutrition and metabolic care.

[52]  P. Leder,et al.  Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. , 2006, Cancer cell.

[53]  Marta Cascante,et al.  K-ras Codon-Specific Mutations Produce Distinctive Metabolic Phenotypes in Human Fibroblasts , 2005 .

[54]  E. Eigenbrodt,et al.  The tumor metabolome. , 2003, Anticancer research.

[55]  P. Leedman,et al.  Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells. , 2002, The Biochemical journal.

[56]  M Cascante,et al.  Gleevec (STI571) influences metabolic enzyme activities and glucose carbon flow toward nucleic acid and fatty acid synthesis in myeloid tumor cells. , 2001, The Journal of biological chemistry.

[57]  F. Kuhajda Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology. , 2000, Nutrition.

[58]  D. Hanahan,et al.  The Hallmarks of Cancer , 2000, Cell.

[59]  Marta Cascante,et al.  Mass isotopomer study of the nonoxidative pathways of the pentose cycle with [1,2-13C2]glucose. , 1998, American journal of physiology. Endocrinology and metabolism.

[60]  R. D. Williams,et al.  Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation. , 1997, Cancer research.

[61]  I. Tannock,et al.  Acid pH in tumors and its potential for therapeutic exploitation. , 1989, Cancer research.

[62]  Hunter N B Moseley,et al.  Stable isotope-labeled tracers for metabolic pathway elucidation by GC-MS and FT-MS. , 2014, Methods in molecular biology.

[63]  N. Henry,et al.  Disease-related outcomes with long-term follow-up: An updated analysis of the intergroup exemestane study , 2013 .

[64]  T. Fan Metabolomics-Edited Transcriptomics Analysis (META) , 2012 .

[65]  이연수 Functional genomics reveal that the serine synthesis pathway is essential in breast cancer , 2011 .

[66]  Andrew N Lane,et al.  Isotopomer-based metabolomic analysis by NMR and mass spectrometry. , 2008, Methods in cell biology.

[67]  Robert J. Gillies,et al.  A microenvironmental model of carcinogenesis , 2008, Nature Reviews Cancer.