Biopolymer-based materials in nanomedicine: Synthesis and characterization

Abstract Nowadays, the use of polymers is almost indispensable to the wide range of applications. Despite their unbeatable usefulness in the biomedical field, nonrenewable resourses, environmental pollution, and biocompatibility are the major limitations that restrict the predominant use of synthetic polymers. Thus, an expedition of the utilization of biopolymers is on a rise. Recently, the development of novel drug delivery systems or nanomedicine utilizing biopolymers enables us to prevent, treat, and diagnose early diseases with unparalleled efficiency and to ensure the accuracy even up to the molecular and genetic levels. This chapter focuses on the applications of biopolymers especially in the field of nanomedicine. Herein, we have briefly described the synthesis, characterization of the largely used and potential biopolymers, and their classifications. In addition, a special emphasis has been given on the uses of biopolymers in the drug delivery approaches from the research viewpoint to clinical applications. The chapter also describes the usefulness of aspiring biopolymers in the current nanomedicine development.

[1]  T. Lammers,et al.  Imaging Nanomedicine-Based Drug Delivery: a Review of Clinical Studies , 2018, Molecular Imaging and Biology.

[2]  M. D. Blanco,et al.  Tamoxifen-loaded thiolated alginate-albumin nanoparticles as antitumoral drug delivery systems. , 2012, Journal of biomedical materials research. Part A.

[3]  Zhong Chen,et al.  Cyclic RGD peptide-modified liposomal drug delivery system: enhanced cellular uptake in vitro and improved pharmacokinetics in rats , 2012, International journal of nanomedicine.

[4]  E. Samain,et al.  Gram-scale synthesis of recombinant chitooligosaccharides in Escherichia coli. , 1997, Carbohydrate research.

[5]  Wonmuk Hwang,et al.  Self-assembly of Surfactant-like Peptides with Variable Glycine Tails to Form Nanotubes and Nanovesicles , 2002 .

[6]  Qiang Zhang,et al.  The eradication of breast cancer and cancer stem cells using octreotide modified paclitaxel active targeting micelles and salinomycin passive targeting micelles. , 2012, Biomaterials.

[7]  M. Bodnár,et al.  Preparation and characterization of chitosan-based nanoparticles. , 2005, Biomacromolecules.

[8]  Erkki Ruoslahti,et al.  Targeting of albumin-embedded paclitaxel nanoparticles to tumors. , 2009, Nanomedicine : nanotechnology, biology, and medicine.

[9]  Todor A Popov,et al.  Effect of micronized cellulose powder on the efficacy of topical oxymetazoline in allergic rhinitis. , 2015, Allergy and asthma proceedings.

[10]  Syed Anees Ahmed,et al.  Biopolymers for Drug Delivery , 2017 .

[11]  H. Ertesvåg,et al.  New insights into Pseudomonas fluorescens alginate biosynthesis relevant for the establishment of an efficient production process for microbial alginates. , 2017, New biotechnology.

[12]  C. Peng,et al.  Calcium‐Alginate Nanoparticles Formed by Reverse Microemulsion as Gene Carriers , 2005 .

[13]  J. V. Hest,et al.  Atom Transfer Radical Polymerization of Adenine, Thymine, Cytosine, and Guanine Nucleobase Monomers , 2007 .

[14]  Qingdi Zhu,et al.  Recent advances of PLGA micro/nanoparticles for the delivery of biomacromolecular therapeutics. , 2018, Materials science & engineering. C, Materials for biological applications.

[15]  L. Meinel,et al.  Application of natural and semi-synthetic polymers for the delivery of sensitive drugs , 2015 .

[16]  K. Kawakami,et al.  Fabrication of solid collagen nanoparticles using electrospray deposition. , 2014, Chemical & pharmaceutical bulletin.

[17]  Robert Langer,et al.  Endothelialized microvasculature based on a biodegradable elastomer. , 2005, Tissue engineering.

[18]  V. Choudhary,et al.  Receptor Specific Macrophage Targeting by Mannose-Conjugated Gelatin Nanoparticles- An In Vitro and In Vivo Study , 2010 .

[19]  Fazilah Ariffin,et al.  Review of Fish Gelatin Extraction, Properties and Packaging Applications , 2016 .

[20]  M. Amiji,et al.  Redox-responsive targeted gelatin nanoparticles for delivery of combination wt-p53 expressing plasmid DNA and gemcitabine in the treatment of pancreatic cancer , 2014, BMC Cancer.

[21]  M. Kariduraganavar,et al.  Smart Biopolymers and their Biomedical Applications , 2017 .

[22]  Ze Lu,et al.  Paclitaxel-Loaded Gelatin Nanoparticles for Intravesical Bladder Cancer Therapy , 2004, Clinical Cancer Research.

[23]  Weixian Xi,et al.  Nucleobase-Containing Polymers: Structure, Synthesis, and Applications , 2017, Polymers.

[24]  Tracy K. Pettinger,et al.  Nanopharmaceuticals (part 1): products on the market , 2014, International journal of nanomedicine.

[25]  A. Bernkop‐Schnürch,et al.  Thiolated polymers: self-crosslinking properties of thiolated 450 kDa poly(acrylic acid) and their influence on mucoadhesion. , 2002, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[26]  Yang Gao,et al.  Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma , 2016, International journal of nanomedicine.

[27]  Yan Xu,et al.  Molecular switch for the assembly of lipophilic drug incorporated plasma protein nanoparticles and in vivo image. , 2012, Biomacromolecules.

[28]  J. Ahn,et al.  The clinical application and efficacy of sodium hyaluronate–carboxymethylcellulose during tympanomastoid surgery , 2012, The Laryngoscope.

[29]  R. Xu,et al.  Targeted albumin-based nanoparticles for delivery of amphipathic drugs. , 2011, Bioconjugate chemistry.

[30]  Shuguang Zhang,et al.  Molecular self-assembly of surfactant-like peptides to form nanotubes and nanovesicles , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[31]  D. Saini,et al.  Exploiting 4-sulphate N-acetyl galactosamine decorated gelatin nanoparticles for effective targeting to professional phagocytes in vitro and in vivo , 2012, Journal of drug targeting.

[32]  P. Han,et al.  Robust neuroprotective effects of intranasally delivered iNOS siRNA encapsulated in gelatin nanoparticles in the postischemic brain. , 2016, Nanomedicine : nanotechnology, biology, and medicine.

[33]  Eric W. Cochran,et al.  The battle for the "green" polymer. Different approaches for biopolymer synthesis: bioadvantaged vs. bioreplacement. , 2014, Organic & biomolecular chemistry.

[34]  Ahmed O Elzoghby,et al.  Gelatin-based nanoparticles as drug and gene delivery systems: reviewing three decades of research. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[35]  K. Slowinska Cross-Linked Collagen Gels Using Gold Nanoparticles. , 2018, Methods in molecular biology.

[36]  T. Muthukumar,et al.  Fish scale collagen sponge incorporated with Macrotyloma uniflorum plant extract as a possible wound/burn dressing material. , 2014, Colloids and surfaces. B, Biointerfaces.

[37]  A. Kelly,et al.  Stability of casein micelles cross-linked by transglutaminase. , 2006, Journal of dairy science.

[38]  B. Mukherjee,et al.  Chitosan-coated nanoparticles enhanced lung pharmacokinetic profile of voriconazole upon pulmonary delivery in mice. , 2018, Nanomedicine.

[39]  Xiaohua Wang,et al.  Polymer-Based Nanomaterials and Applications for Vaccines and Drugs , 2018, Polymers.

[40]  C. G. D. Kruif,et al.  Structure and stability of nanogel particles prepared by internal cross-linking of casein micelles , 2008 .

[41]  Sung-Bin Park,et al.  Biopolymer-based functional composites for medical applications , 2017 .

[42]  Kristofer J. Thurecht,et al.  Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date , 2016, Pharmaceutical Research.

[43]  G. Morelli,et al.  Liposomes derivatized with multimeric copies of KCCYSL peptide as targeting agents for HER-2-overexpressing tumor cells , 2017, International journal of nanomedicine.

[44]  Porntip Pan-in,et al.  Depositing α-mangostin nanoparticles to sebaceous gland area for acne treatment. , 2015, Journal of pharmacological sciences.

[45]  I. Kwon,et al.  Preparation of chitosan self-aggregates as a gene delivery system. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[46]  Leonardo Fernandes Fraceto,et al.  Nano based drug delivery systems: recent developments and future prospects , 2018, Journal of Nanobiotechnology.

[47]  Qiang Zhang,et al.  Targeted Polymeric Micelle System for Delivery of Combretastatin A4 to Tumor Vasculature In Vitro , 2010, Pharmaceutical Research.

[48]  S. Mohan,et al.  Biopolymers – Application in Nanoscience and Nanotechnology , 2016 .

[49]  Basel Younes,et al.  Classification, characterization, and the production processes of biopolymers used in the textiles industry , 2017 .

[50]  Rohit Bhargava,et al.  Using Fourier transform IR spectroscopy to analyze biological materials , 2014, Nature Protocols.

[51]  Yoav D Livney,et al.  β-Casein nanoparticle-based oral drug delivery system for potential treatment of gastric carcinoma: stability, target-activated release and cytotoxicity. , 2012, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[52]  Z. Fayad,et al.  Integrating nanomedicine and imaging , 2017, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[53]  Jie Tang,et al.  A pH-responsive α-helical cell penetrating peptide-mediated liposomal delivery system. , 2013, Biomaterials.

[54]  A. Tiwary,et al.  Mannan-coated gelatin nanoparticles for sustained and targeted delivery of didanosine: In vitro and in vivo evaluation , 2008, Acta pharmaceutica.

[55]  A. Mandal,et al.  Chitosan nanoparticles as a dual growth factor delivery system for tissue engineering applications. , 2011, International journal of pharmaceutics.

[56]  Amit Jain,et al.  Nanotechnology: A magic bullet for HIV AIDS treatment , 2015, Artificial cells, nanomedicine, and biotechnology.

[57]  M. J. Santander-Ortega,et al.  Nanoparticles made from novel starch derivatives for transdermal drug delivery. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[58]  S. Fuchs,et al.  Targeting CpG Oligonucleotides to the Lymph Node by Nanoparticles Elicits Efficient Antitumoral Immunity1 , 2008, The Journal of Immunology.

[59]  Yuquan Wei,et al.  Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment , 2014, Nature Communications.

[60]  Young Hee Choi,et al.  Nanomedicines: current status and future perspectives in aspect of drug delivery and pharmacokinetics , 2017, Journal of Pharmaceutical Investigation.

[61]  Meiwan Chen,et al.  iRGD decorated lipid-polymer hybrid nanoparticles for targeted co-delivery of doxorubicin and sorafenib to enhance anti-hepatocellular carcinoma efficacy. , 2016, Nanomedicine : nanotechnology, biology, and medicine.

[62]  A. Annapragada,et al.  Glucose-sensing pulmonary delivery of human insulin to the systemic circulation of rats , 2007, International journal of nanomedicine.

[63]  Maryam Tabrizian,et al.  Effects of alginate inclusion on the vector properties of chitosan-based nanoparticles. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[64]  Y. Tabata,et al.  Gelatin nanospheres incorporating siRNA for controlled intracellular release. , 2012, Biomaterials.

[65]  M. Sargon,et al.  Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery. , 2000, International journal of pharmaceutics.

[66]  G. Morelli,et al.  Micelles derivatized with octreotide as potential target‐selective contrast agents in MRI , 2009, Journal of peptide science : an official publication of the European Peptide Society.

[67]  M. M. Zgoda,et al.  [Natural biopolymers as excipients in medicinal product dosage form. Part I. Soft gelatin capsules as a modern and elegant pharmaceutical dosage form]. , 2010, Polymers in Medicine.

[68]  S. Percival,et al.  Fabrication of nanoparticles using partially purified pomegranate ellagitannins and gelatin and their apoptotic effects. , 2011, Molecular nutrition & food research.

[69]  S. Karthikeyan,et al.  Anticancer activity of resveratrol-loaded gelatin nanoparticles on NCI-H460 non-small cell lung cancer cells , 2013 .

[70]  R. Mahanta,et al.  Controlled release of tamoxifen citrate encapsulated in cross-linked guar gum nanoparticles. , 2011, International journal of biological macromolecules.

[71]  B. Sarmento,et al.  Insulin-loaded nanoparticles are prepared by alginate ionotropic pre-gelation followed by chitosan polyelectrolyte complexation. , 2007, Journal of nanoscience and nanotechnology.

[72]  Joel A. Cohen,et al.  Mannosylated dextran nanoparticles: a pH-sensitive system engineered for immunomodulation through mannose targeting. , 2011, Bioconjugate chemistry.

[73]  G. Morelli,et al.  Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery , 2015, Journal of peptide science : an official publication of the European Peptide Society.

[74]  Maria Jose Alonso,et al.  Ionically crosslinked chitosan/tripolyphosphate nanoparticles for oligonucleotide and plasmid DNA delivery. , 2009, International journal of pharmaceutics.

[75]  C. L. Ventola,et al.  Progress in Nanomedicine: Approved and Investigational Nanodrugs. , 2017, P & T : a peer-reviewed journal for formulary management.

[76]  Hagen von Briesen,et al.  Selective targeting of antibody-conjugated nanoparticles to leukemic cells and primary T-lymphocytes. , 2005, Biomaterials.

[77]  A. Bajpai,et al.  In vitro release dynamics of an anticancer drug from swellable gelatin nanoparticles , 2006 .

[78]  K. Na,et al.  Polysaacharide as a Drug-Coating Polymer , 2000 .

[79]  Patrick Soon-Shiong,et al.  Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with cremophor-based paclitaxel. , 2006, Clinical cancer research : an official journal of the American Association for Cancer Research.

[80]  F. Buonaguro,et al.  Cell Penetrating Peptides as Molecular Carriers for Anti-Cancer Agents , 2018, Molecules.

[81]  Keiji Numata,et al.  Biopolymer-Based Nanoparticles for Drug/Gene Delivery and Tissue Engineering , 2013, International journal of molecular sciences.

[82]  Takahiro Nomoto,et al.  Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood-brain tumor barrier. , 2013, ACS nano.

[83]  Kristala L. J. Prather,et al.  Synthetic biology strategies for improving microbial synthesis of “green” biopolymers , 2018, The Journal of Biological Chemistry.

[84]  R. Mumper,et al.  Chitosan-based nanoparticles for topical genetic immunization. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[85]  T. Goudoulas Polymers and Biopolymers as Drug Delivery Systems in Nanomedicine , 2012 .

[86]  Yehuda G. Assaraf,et al.  β-casein nanovehicles for oral delivery of chemotherapeutic drug combinations overcoming P-glycoprotein-mediated multidrug resistance in human gastric cancer cells , 2016, Oncotarget.

[87]  M. Stack,et al.  Methods for the visualization and analysis of extracellular matrix protein structure and degradation. , 2018, Methods in cell biology.

[88]  M. Jaafari,et al.  Improvement of pharmacokinetic and antitumor activity of PEGylated liposomal doxorubicin by targeting with N-methylated cyclic RGD peptide in mice bearing C-26 colon carcinomas. , 2013, International journal of pharmaceutics.

[89]  Shuguang Zhang,et al.  Positively Charged Surfactant-like Peptides Self-assemble into Nanostructures , 2003 .

[90]  F. Forni,et al.  Doxorubicin-loaded gelatin nanoparticles stabilized by glutaraldehyde: Involvement of the drug in the cross-linking process , 1997 .

[91]  P. Rothemund Folding DNA to create nanoscale shapes and patterns , 2006, Nature.

[92]  Chunxi Wang,et al.  Poly(Ethylene Glycol)–Polylactide Micelles for Cancer Therapy , 2018, Front. Pharmacol..

[93]  Jörg Huwyler,et al.  Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[94]  A. Singh Biopolymers in Drug Delivery: A Review , 2011 .

[95]  S. Houng,et al.  Nanoparticulate delivery system for insulin: design, characterization and in vitro/in vivo bioactivity. , 2007, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[96]  David J. Pine,et al.  Towards self-replicating materials of DNA-functionalized colloids , 2009 .

[97]  M. Witek,et al.  Hydration water dynamics in biopolymers from NMR relaxation in the rotating frame. , 2010, Journal of magnetic resonance.

[98]  Lisbeth Ilium,et al.  Chitosan and Its Use as a Pharmaceutical Excipient , 1998, Pharmaceutical Research.

[99]  G. Morelli,et al.  Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery , 2013, Journal of peptide science : an official publication of the European Peptide Society.

[100]  Jeong Byeongmoon,et al.  Lessons from nature: stimuli-responsive polymers and their biomedical applications. , 2002, Trends in biotechnology.

[101]  Mansoor Amiji,et al.  Tumor-Targeted Gene Delivery Using Poly(Ethylene Glycol)-Modified Gelatin Nanoparticles: In Vitro and in Vivo Studies , 2005, Pharmaceutical Research.