Synergistic Effects of Hyperandrogenemia and Obesogenic Western-style Diet on Transcription and DNA Methylation in Visceral Adipose Tissue of Nonhuman Primates

[1]  M. Cerbón,et al.  DNA Methylation in the Pathogenesis of Polycystic Ovary Syndrome. , 2019, Reproduction.

[2]  D. Erikson,et al.  Chronically elevated androgen and/or consumption of a Western-style diet impairs oocyte quality and granulosa cell function in the nonhuman primate periovulatory follicle , 2019, Journal of Assisted Reproduction and Genetics.

[3]  D. Abbott,et al.  Adipose Insulin Resistance in Normal-Weight Women With Polycystic Ovary Syndrome. , 2019, The Journal of clinical endocrinology and metabolism.

[4]  J. Goldstein,et al.  Sex Differences in the Prenatal Programming of Adult Metabolic Syndrome by Maternal Androgens , 2018, The Journal of clinical endocrinology and metabolism.

[5]  J. Rozenberg,et al.  RBPJ binds to consensus and methylated cis elements within phased nucleosomes and controls gene expression in human aortic smooth muscle cells in cooperation with SRF , 2018, Nucleic acids research.

[6]  J. Rozenberg,et al.  RBPJ binds to consensus and methylated cis elements within phased nucleosomes and controls gene expression in human aortic smooth muscle cells in cooperation with SRF , 2018, Nucleic acids research.

[7]  R. Stouffer,et al.  Chronic hyperandrogenemia and western-style diet beginning at puberty reduces fertility and increases metabolic dysfunction during pregnancy in young adult, female macaques , 2018, Human reproduction.

[8]  C. Ling,et al.  A Single Bout of Electroacupuncture Remodels Epigenetic and Transcriptional Changes in Adipose Tissue in Polycystic Ovary Syndrome , 2018, Scientific Reports.

[9]  D. Glintborg,et al.  Development and Risk Factors of Type 2 Diabetes in a Nationwide Population of Women With Polycystic Ovary Syndrome , 2017, The Journal of clinical endocrinology and metabolism.

[10]  C. Roberts,et al.  Combined androgen excess and Western-style diet accelerates adipose tissue dysfunction in young adult, female nonhuman primates , 2017, Human reproduction.

[11]  N. Ryan,et al.  Chronic combined hyperandrogenemia and western-style diet in young female rhesus macaques causes greater metabolic impairments compared to either treatment alone , 2017, Human reproduction.

[12]  Chunyan Zhao,et al.  Epigenetic Regulation of PLIN1 in Obese Women and its Relation to Lipolysis , 2017, Scientific Reports.

[13]  Xia Zhao,et al.  Association of polycystic ovary syndrome with metabolic syndrome and gestational diabetes: Aggravated complication of pregnancy , 2017, Experimental and therapeutic medicine.

[14]  M. Diamond,et al.  Phenotypes and body mass in women with polycystic ovary syndrome identified in referral versus unselected populations: systematic review and meta-analysis. , 2016, Fertility and sterility.

[15]  D. Margolis,et al.  Hyperandrogenism Accompanies Increased Intra-Abdominal Fat Storage in Normal Weight Polycystic Ovary Syndrome Women. , 2016, The Journal of clinical endocrinology and metabolism.

[16]  D. Rajpal,et al.  The epigenetic signature of systemic insulin resistance in obese women , 2016, Diabetologia.

[17]  K. Behnia,et al.  Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils. , 2016, Cell Metabolism.

[18]  S. Kajimura,et al.  Transcriptional and epigenetic control of brown and beige adipose cell fate and function , 2016, Nature Reviews Molecular Cell Biology.

[19]  C. Behre,et al.  Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome , 2016, Scientific Reports.

[20]  Matthew R. Walter,et al.  Lipoprotein Particles in Adolescents and Young Women With PCOS Provide Insights Into Their Cardiovascular Risk. , 2015, The Journal of clinical endocrinology and metabolism.

[21]  N. Webster,et al.  A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice1 , 2015, Biology of reproduction.

[22]  K. Taylor,et al.  Systems Genetics Reveals the Functional Context of PCOS Loci and Identifies Genetic and Molecular Mechanisms of Disease Heterogeneity , 2015, PLoS Genetics.

[23]  F. Hu,et al.  Advances in the Science, Treatment, and Prevention of the Disease of Obesity: Reflections From a Diabetes Care Editors’ Expert Forum , 2015, Diabetes Care.

[24]  S. Kwak,et al.  Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance , 2015, Nature Communications.

[25]  V. Padmanabhan,et al.  Steroidogenic versus Metabolic Programming of Reproductive Neuroendocrine, Ovarian and Metabolic Dysfunctions , 2015, Neuroendocrinology.

[26]  C. Ling,et al.  The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes , 2015, International Journal of Obesity.

[27]  I. Shimomura,et al.  Fat/Vessel-derived Secretory Protein (Favine)/CCDC3 Is Involved in Lipid Accumulation* , 2015, The Journal of Biological Chemistry.

[28]  Jelica Bjekić Macut,et al.  Possible involvement of glucocorticoids in 5α-dihydrotestosterone-induced PCOS-like metabolic disturbances in the rat visceral adipose tissue , 2015, Molecular and Cellular Endocrinology.

[29]  H. Teede,et al.  Polycystic ovary syndrome. , 2014, Nature reviews. Disease primers.

[30]  J. Rozenberg,et al.  DNA Methylation of a GC Repressor Element in the Smooth Muscle Myosin Heavy Chain Promoter Facilitates Binding of the Notch-Associated Transcription Factor, RBPJ/CSL1 , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[31]  C. Roberts,et al.  Sex-Specific Differences in Lipid and Glucose Metabolism , 2014, Front. Endocrinol..

[32]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[33]  M. Diamond,et al.  The expression of the miR-25/93/106b family of micro-RNAs in the adipose tissue of women with polycystic ovary syndrome. , 2014, The Journal of clinical endocrinology and metabolism.

[34]  M. Fasshauer,et al.  Global DNA methylation levels in human adipose tissue are related to fat distribution and glucose homeostasis , 2014, Diabetologia.

[35]  David Handelsman,et al.  Characterization of reproductive, metabolic, and endocrine features of polycystic ovary syndrome in female hyperandrogenic mouse models. , 2014, Endocrinology.

[36]  A. Janež,et al.  Phosphodiesterase 4 inhibition as a potential new therapeutic target in obese women with polycystic ovary syndrome. , 2014, The Journal of clinical endocrinology and metabolism.

[37]  C. Ling,et al.  Altered DNA Methylation and Differential Expression of Genes Influencing Metabolism and Inflammation in Adipose Tissue From Subjects With Type 2 Diabetes , 2014, Diabetes.

[38]  E. Stener-Victorin,et al.  Rodent Models of Polycystic Ovary Syndrome: Phenotypic Presentation, Pathophysiology, and the Effects of Different Interventions , 2014, Seminars in Reproductive Medicine.

[39]  Björn Usadel,et al.  Trimmomatic: a flexible trimmer for Illumina sequence data , 2014, Bioinform..

[40]  K. Morino,et al.  CCDC3 is specifically upregulated in omental adipose tissue in subjects with abdominal obesity , 2014, Obesity.

[41]  Charity W. Law,et al.  voom: precision weights unlock linear model analysis tools for RNA-seq read counts , 2014, Genome Biology.

[42]  P. Farnham,et al.  Cross-talk between Site-specific Transcription Factors and DNA Methylation States* , 2013, The Journal of Biological Chemistry.

[43]  J. Cameron,et al.  Ovarian cycle-specific regulation of adipose tissue lipid storage by testosterone in female nonhuman primates. , 2013, Endocrinology.

[44]  V. Padmanabhan,et al.  Sheep models of polycystic ovary syndrome phenotype , 2013, Molecular and Cellular Endocrinology.

[45]  G. Karsenty,et al.  Developmental androgen excess programs sympathetic tone and adipose tissue dysfunction and predisposes to a cardiometabolic syndrome in female mice. , 2013, American journal of physiology. Endocrinology and metabolism.

[46]  D. Stepp,et al.  miRNA-93 Inhibits GLUT4 and Is Overexpressed in Adipose Tissue of Polycystic Ovary Syndrome Patients and Women With Insulin Resistance , 2013, Diabetes.

[47]  Leif Groop,et al.  A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue , 2013, PLoS genetics.

[48]  J. Gustafsson,et al.  LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob/ob female mice[S] , 2013, Journal of Lipid Research.

[49]  E. Chen,et al.  Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool , 2013, BMC Bioinformatics.

[50]  Timothy E. Reddy,et al.  Dynamic DNA methylation across diverse human cell lines and tissues , 2013, Genome research.

[51]  D. Dey,et al.  Effects of endogenous androgens and abdominal fat distribution on the interrelationship between insulin and non-insulin-mediated glucose uptake in females. , 2013, The Journal of clinical endocrinology and metabolism.

[52]  Brent S. Pedersen,et al.  Comb-p: software for combining, analyzing, grouping and correcting spatially correlated P-values , 2012, Bioinform..

[53]  Raymond K. Auerbach,et al.  An Integrated Encyclopedia of DNA Elements in the Human Genome , 2012, Nature.

[54]  V. Tomić,et al.  Infertility Treatment in Patients with Polycystic Ovary Syndrome (PCOS) , 2012 .

[55]  J. Cameron,et al.  Elevated androgens during puberty in female rhesus monkeys lead to increased neuronal drive to the reproductive axis: a possible component of polycystic ovary syndrome. , 2012, Human reproduction.

[56]  Xiuqing Guo,et al.  Epigenetic Mechanism Underlying the Development of Polycystic Ovary Syndrome (PCOS)-Like Phenotypes in Prenatally Androgenized Rhesus Monkeys , 2011, PloS one.

[57]  Felix Krueger,et al.  Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications , 2011, Bioinform..

[58]  L. Lönn,et al.  Adipose tissue has aberrant morphology and function in PCOS: enlarged adipocytes and low serum adiponectin, but not circulating sex steroids, are strongly associated with insulin resistance. , 2011, The Journal of clinical endocrinology and metabolism.

[59]  S. Keller,et al.  Prenatal androgen exposure programs metabolic dysfunction in female mice. , 2010, The Journal of endocrinology.

[60]  S. Caprio,et al.  Hyperandrogenemia in Obese Peripubertal Girls: Correlates and Potential Etiological Determinants , 2010, Obesity.

[61]  A. Balen,et al.  The adverse effects of obesity on conception and implantation. , 2010, Reproduction.

[62]  C. Glass,et al.  Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. , 2010, Molecular cell.

[63]  Cory Y. McLean,et al.  GREAT improves functional interpretation of cis-regulatory regions , 2010, Nature Biotechnology.

[64]  R. Legro,et al.  High prevalence of metabolic syndrome in first-degree male relatives of women with polycystic ovary syndrome is related to high rates of obesity. , 2009, The Journal of clinical endocrinology and metabolism.

[65]  F. Zhang,et al.  FABP4: a novel candidate gene for polycystic ovary syndrome , 2009, Endocrine.

[66]  K. Seow,et al.  Omental adipose tissue overexpression of fatty acid transporter CD36 and decreased expression of hormone-sensitive lipase in insulin-resistant women with polycystic ovary syndrome. , 2009, Human reproduction.

[67]  A. Hingorani,et al.  Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis , 2009, The Lancet.

[68]  Israel Steinfeld,et al.  BMC Bioinformatics BioMed Central , 2008 .

[69]  T. Mikkelsen,et al.  Genome-scale DNA methylation maps of pluripotent and differentiated cells , 2008, Nature.

[70]  E. Stener-Victorin,et al.  Low-frequency electro-acupuncture and physical exercise improve metabolic disturbances and modulate gene expression in adipose tissue in rats with dihydrotestosterone-induced polycystic ovary syndrome. , 2008, Endocrinology.

[71]  E. Codner,et al.  Metabolic profile in sons of women with polycystic ovary syndrome. , 2008, The Journal of clinical endocrinology and metabolism.

[72]  C. Kahn,et al.  Developmental Origin of Fat: Tracking Obesity to Its Source , 2007, Cell.

[73]  P. Arner,et al.  Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis. , 2007, American journal of physiology. Endocrinology and metabolism.

[74]  S. Caprio,et al.  Obesity and sex steroid changes across puberty: evidence for marked hyperandrogenemia in pre- and early pubertal obese girls. , 2007, The Journal of clinical endocrinology and metabolism.

[75]  P. Fraser.  Transcriptional control thrown for a loop. , 2006, Current opinion in genetics & development.

[76]  J. Marshall,et al.  The association of obesity and hyperandrogenemia during the pubertal transition in girls: obesity as a potential factor in the genesis of postpubertal hyperandrogenism. , 2006, The Journal of clinical endocrinology and metabolism.

[77]  R. Pasquali,et al.  Obesity and reproductive disorders in women. , 2003, Human reproduction update.

[78]  P. Arner,et al.  Mechanisms behind lipolytic catecholamine resistance of subcutaneous fat cells in the polycystic ovarian syndrome. , 2003, The Journal of clinical endocrinology and metabolism.

[79]  R. Colman,et al.  Increased adiposity in female rhesus monkeys exposed to androgen excess during early gestation. , 2003, Obesity research.

[80]  P. Arner,et al.  A unique defect in the regulation of visceral fat cell lipolysis in the polycystic ovary syndrome as an early link to insulin resistance. , 2002, Diabetes.

[81]  R. Colman,et al.  Insights into the Development of Polycystic Ovary Syndrome (PCOS) from Studies of Prenatally Androgenized Female Rhesus Monkeys , 1998, Trends in Endocrinology & Metabolism.

[82]  P. Arner,et al.  Impaired adipocyte lipolysis in nonobese women with the polycystic ovary syndrome: a possible link to insulin resistance? , 1997, The Journal of clinical endocrinology and metabolism.

[83]  M. Fortini,et al.  The suppressor of hairless protein participates in notch receptor signaling , 1994, Cell.

[84]  V. Sulmont,et al.  Roles of LH and insulin resistance in lean and obese polycystic ovary syndrome , 1993, Clinical endocrinology.

[85]  R. Legro,et al.  Polycystic ovary syndrome. , 1992, Current therapy in endocrinology and metabolism.

[86]  R. Stouffer,et al.  Chronic hyperandrogenemia in the presence and absence of a western-style diet impairs ovarian and uterine structure/function in young adult rhesus monkeys , 2018, Human reproduction.

[87]  Thomas R. Gingeras,et al.  STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..

[88]  Alberto Benguría,et al.  Differential gene expression profile in omental adipose tissue in women with polycystic ovary syndrome. , 2007, The Journal of clinical endocrinology and metabolism.

[89]  Peter Tontonoz,et al.  Reciprocal regulation of inflammation and lipid metabolism by liver X receptors , 2003, Nature Medicine.

[90]  P. Jones,et al.  The DNA methylation paradox. , 1999, Trends in genetics : TIG.