Radioisotope synovectomy with $sup 32$P-chromic phosphate-kinetic studies

In selected cases of rheumatoid disease, intrasynovial instillation of radionuclides may be used as a means of controlling recurring synovial effusions. In addition to an effective beta emission, the isotope chosen must be complexed into a stable particle that will be rapidly incorporated into the synovial tissue and remain there./sup 32/P-chromic phosphate was evaluated in nine patients following instillation into the knee joint. In eight of these, no leakage of radioactivity could be detected. In one case, beginning 4 days postinstillation, some migration of radioactivity to the ipsilateral inguinal nodes and, to a lesser extent, the sacrum and liver was found. This suggests that /sup 32/P- chromic phosphate has greater stability than materials previously used. (auth)