Electrocardiographic Alterations during Hyperinsulinemic Hypoglycemia in Healthy Subjects

Background: We evaluated the arrhythmogenic potential of hypoglycemia by studying electrocardiographic (ECG) changes in response to hyperinsulinemic hypoglycemia and associated sympathoadrenal counterregulatory responses in healthy subjects.

[1]  S. Oram,et al.  MODIFICATION BY PROPRANOLOL OF CARDIOVASCULAR EFFECTS OF INDUCED HYPOGLYCÆMIA , 1975, The Lancet.

[2]  Opie Lh.  Effects of regional ischemia on metabolism of glucose and fatty acids. Relative rates of aerobic and anaerobic energy production during myocardial infarction and comparison with effects of anoxia. , 1976 .

[3]  L. Opie.  Effects of Regional Ischemia on Metabolism of Glucose and Fatty Acids: Relative Rates of Aerobic and Anaerobic Energy Production during Myocardial Infarction and Comparison with Effects of Anoxia , 1976, Circulation research.

[4]  R. DeFronzo,et al.  Glucose clamp technique: a method for quantifying insulin secretion and resistance. , 1979, The American journal of physiology.

[5]  J W Rowe,et al.  Effect of Insulin and Glucose Infusions on Sympathetic Nervous System Activity in Normal Man , 1981, Diabetes.

[6]  J. Brachmann,et al.  Electrophysiological effects of glucose-insulin-potassium on atrioventricular conduction in man. , 1982, Cardiovascular research.

[7]  A. Spiers,et al.  Hemorrhagic cystitis after low-dose cyclophosphamide. , 1983, Lancet.

[8]  J. Reid,et al.  Metabolic and haemodynamic effects of increased circulating adrenaline in man. Effect of labetalol, an alpha and beta blocker. , 1983, British heart journal.

[9]  Hypoglycemia-induced silent myocardial ischemia. , 1989, The American journal of cardiology.

[10]  E. Potter,et al.  Vagal action on atrioventricular conduction and its inhibition by sympathetic stimulation and neuropeptide Y in anaesthetised dogs. , 1990, Journal of the autonomic nervous system.

[11]  L. Jorfeldt,et al.  Hypoglycaemia and Cardiac Arrhythmias in Patients with Type 2 Diabetes Mellitus , 1992, Diabetic medicine : a journal of the British Diabetic Association.

[12]  M. Feinglos,et al.  Hypoglycemia-Induced Angina Pectoris in a Patient with Diabetes Mellitus , 1994, Annals of Internal Medicine.

[13]  Jefferson Luiz Brum Marques,et al.  Altered ventricular repolarization during hypoglycaemia in patients with diabetes , 1997, Diabetic medicine : a journal of the British Diabetic Association.

[14]  P. Cryer,et al.  Forearm norepinephrine spillover during standing, hyperinsulinemia, and hypoglycemia. , 1998, The American journal of physiology.

[15]  Ischemic change on electrocardiogram induced by hypoglycemia in a diabetic patient. , 1998, Japanese circulation journal.

[16]  B. Eckert,et al.  Hypoglycaemia leads to an increased QT interval in normal men. , 1998, Clinical physiology.

[17]  L Heinemann,et al.  Electrocardiographic changes during insulin-induced hypoglycemia in healthy subjects. , 1998, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[18]  Y. Iwamoto,et al.  An IDDM patient who complained of chest oppression with ischemic changes on ECG in insulin-induced hypoglycemia. , 1998, Diabetes research and clinical practice.

[19]  Hypoglycemia per se stimulates sympathetic neural as well as adrenomedullary activity, but, unlike the adrenomedullary response, the forearm sympathetic neural response is not reduced after recent hypoglycemia. , 1999, Diabetes.

[20]  Jefferson Luiz Brum Marques,et al.  Measurement of high resolution ECG QT interval during controlled euglycaemia and hypoglycaemia. , 2000, Physiological measurement.

[21]  F Conforti,et al.  Insulin prolongs the QTc interval in humans. , 2000, American journal of physiology. Regulatory, integrative and comparative physiology.

[22]  H. Huopio,et al.  Carriers of an inactivating beta-cell ATP-sensitive K(+) channel mutation have normal glucose tolerance and insulin sensitivity and appropriate insulin secretion. , 2002, Diabetes care.

[23]  T. Laitinen,et al.  Effects of euglycaemic and hypoglycaemic hyperinsulinaemia on sympathetic and parasympathetic regulation of haemodynamics in healthy subjects. , 2003, Clinical science.

[24]  N. Harris,et al.  Mechanisms of abnormal cardiac repolarization during insulin-induced hypoglycemia. , 2003, Diabetes.

[25]  I. Macdonald,et al.  Effects of adrenaline and potassium on QTc interval and QT dispersion in man , 2003, European journal of clinical investigation.

[26]  N. Harris,et al.  Changes in cardiac repolarization during clinical episodes of nocturnal hypoglycaemia in adults with Type 1 diabetes , 2004, Diabetologia.

[27]  T. Laitinen,et al.  Prolonged corrected QT interval is associated with acute and chronic hyperinsulinemia in nondiabetic subjects. , 2003, Diabetes care.

[28]  Benjamin Cheong,et al.  Association of hypoglycemia and cardiac ischemia: a study based on continuous monitoring. , 2002, Diabetes care.

[29]  P. Hjemdahl,et al.  The sympathetic response to euglycaemic hyperinsulinaemia , 1992, Diabetologia.

[30]  D. Dunger,et al.  Prolonged cardiac repolarisation during spontaneous nocturnal hypoglycaemia in children and adolescents with type 1 diabetes , 2004, Diabetologia.

[31]  Prolongation of QT Interval by Terbutaline in Healthy Subjects , 2005, Journal of cardiovascular pharmacology.

[32]  N. Harris,et al.  Effect of atenolol on QTc interval lengthening during hypoglycaemia in type 1 diabetes , 2005, Diabetologia.