Animating platelet production adds physiological context.

Animating complex biological processes contextualizes them within their underlying physiology, identifies gaps in our mechanistic understanding, affirms the importance of continued research, and provides a bridge between academic scientists and the general public. Here, two videos illustrate the clinical value of and translate state-of-the-art research in platelet production.

[1]  J. Italiano,et al.  Platelets: production, morphology and ultrastructure. , 2012, Handbook of experimental pharmacology.

[2]  A. Mogilner,et al.  Microtubule and cortical forces determine platelet size during vascular platelet production , 2012, Nature Communications.

[3]  S. Rafii,et al.  Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis , 2004, Nature Medicine.

[4]  A. Paivio Imagery and verbal processes , 1972 .

[5]  L. Zon,et al.  Hematopoiesis: An Evolving Paradigm for Stem Cell Biology , 2008, Cell.

[6]  F. Tablin,et al.  Blood platelet formation in vitro. The role of the cytoskeleton in megakaryocyte fragmentation. , 1990, Journal of cell science.

[7]  J. Hartwig,et al.  Cytoskeletal mechanics of proplatelet maturation and platelet release , 2010, The Journal of cell biology.

[8]  Joseph E Italiano,et al.  Mechanisms of organelle transport and capture along proplatelets during platelet production. , 2005, Blood.

[9]  R. P. Becker,et al.  The transmural passage of blood cells into myeloid sinusoids and the entry of platelets into the sinusoidal circulation; a scanning electron microscopic investigation. , 1976, The American journal of anatomy.

[10]  R. Leven,et al.  Megakaryocyte motility and platelet formation. , 1987, Scanning microscopy.

[11]  J. Italiano,et al.  Does size matter in platelet production? , 2012, Blood.

[12]  Joseph E Italiano,et al.  Dynamic Visualization of Thrombopoiesis Within Bone Marrow , 2007, Science.

[13]  Chris Toumey Science and democracy , 2006, Nature nanotechnology.

[14]  J. McCullough Overview of platelet transfusion. , 2010, Seminars in hematology.