Disorders of human consciousness in the Tri-partite synapses.

Conscious Action Theory extends quantum theory to macroscopic phenomena and suggests physical correlates of consciousness occur at the intersection of external measurement signals and internally generated signals from memories that model the outside world. This physical theory predicts conscious phenomena happen at all scales and differ only by the size and complexity of material organizations involved. At the scale of the human "Brain" consciousness is predicted to happen where the processing loop of activity in the Glial network interfaces with the real world input-output processing loop of the Nuronal network. This happens at the Tripartite synapses creating an intersection plenum in biological systems that produces the experience of empty space and the objects it contains. Analysis of the transmitter-receptor strengths implementing the control and feedback between the Glial and Neuronal networks indicate imbalances can be directly related to schizophrenia, mania, epilepsy, and depression. This paper addresses three topics supporting the above mechanisms for normal consciousness functioning and its medical deviations. First we preset the architecture of a pan-psychic physical theory, which supports the hypothesis that tri-partite synapses are the location of human conscious experience. Second we discuss the inner workings of the Glial network to support long term memory and control functions corresponding to the inner feeling of the "I" self. Third, we consider the relation between psychiatric conditions and the balance states between the number of neuronal transmitters and astrocytic receptors.

[1]  M. Bourin,et al.  Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder , 2007, Acta psychiatrica Scandinavica. Supplementum.

[2]  A. Verkhratsky,et al.  Astrogliopathology: a central element of neuropsychiatric diseases? , 2014, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[3]  Maiken Nedergaard,et al.  Glial calcium and diseases of the nervous system. , 2010, Cell calcium.

[4]  Demis Basso,et al.  The role of the feedforward paradigm in cognitive psychology , 2006, Cognitive Processing.

[5]  G. Carmignoto,et al.  The Role of Astroglia in the Epileptic Brain , 2012, Front. Pharmacol..

[6]  B. Mitterauer Balancing and imbalancing effects of astrocytic receptors in tripartite synapses. Common pathophysiological model of mental disorders and epilepsy. , 2015, Medical hypotheses.

[7]  Shotai Kobayashi,et al.  Upregulation of Protease-Activated Receptor-1 in Astrocytes in Parkinson Disease: Astrocyte-Mediated Neuroprotection Through Increased Levels of Glutathione Peroxidase , 2006, Journal of neuropathology and experimental neurology.

[8]  O. Steinlein Calcium signaling and epilepsy , 2014, Cell and Tissue Research.

[9]  Justin T. Baker,et al.  Functional connectomics of affective and psychotic pathology , 2019, Proceedings of the National Academy of Sciences.

[10]  P. Gebicke-haerter Engram formation in psychiatric disorders , 2014, Front. Neurosci..

[11]  R. Quirion,et al.  Upregulation of astrocytic α7 nicotinic receptors in Alzheimer's disease brain- possible relevant to amyloid pathology , 2012, Molecular Neurodegeneration.

[12]  John A. Talbott,et al.  The American Psychiatric Press textbook of psychiatry , 1999 .

[13]  P. Schwartzkroin,et al.  Role of Astrocyte Dysfunction in Epilepsy , 2009 .

[14]  ON THE NECESSITY OF INCLUDING THE OBSERVER IN PHYSICAL THEORY , 2015 .

[15]  Helmut Kettenmann,et al.  Astrocyte responses to neuronal activity , 2004, Glia.

[16]  Robert W McCarley,et al.  Gamma oscillation deficits and the onset and early progression of schizophrenia. , 2010, Harvard review of psychiatry.

[17]  B. Mitterauer Pathophysiology of Schizophrenia Based on Impaired Glial-Neuronal Interactions , 2014 .

[18]  A. Verkhratsky,et al.  Astroglia, Glutamatergic Transmission and Psychiatric Diseases. , 2016, Advances in neurobiology.

[19]  J. Ford,et al.  Resting-state EEG delta power is associated with psychological pain in adults with a history of depression , 2015, Biological Psychology.

[20]  D. Coulter,et al.  Role of astrocytes in epilepsy. , 2015, Cold Spring Harbor perspectives in medicine.

[21]  H. Kettenmann,et al.  Release of gliotransmitters and transmitter receptors in astrocytes , 2013 .

[22]  M. Banasr,et al.  Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors , 2008, Biological Psychiatry.

[23]  B. Mitterauer Psychobiological Model of Bipolar Disorder: Based on Imbalances of Glial-Neuronal Information Processing , 2018 .

[24]  M. Lidow,et al.  Calcium signaling dysfunction in schizophrenia: a unifying approach , 2003, Brain Research Reviews.

[25]  B. Mitterauer Disintegration of the Astroglial Domain Organization May Underlie the Loss of Reality Comprehension in Schizophrenia: A Hypothetical Model , 2019, Open Journal of Medical Psychology.

[26]  G. Rajkowska,et al.  Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue. , 2013, Current drug targets.

[27]  B. Kastrup The Universe in Consciousness , 2018 .

[28]  Henri Korn,et al.  Long-term potentiation of electrotonic coupling at mixed synapses , 1990, Nature.

[29]  Christian Giaume,et al.  Control of gap-junctional communication in astrocytic networks , 1996, Trends in Neurosciences.

[30]  B. Mitterauer Imbalances of Tripartite Synapses Responsible for the Pathophysiology of Mental Disorders and Epilepsy , 2018, Journal of Neurology & Neuromedicine.

[31]  A. Araque,et al.  Tripartite synapses: glia, the unacknowledged partner , 1999, Trends in Neurosciences.

[32]  Harald Sontheimer,et al.  Glia as drivers of abnormal neuronal activity , 2015, Nature Neuroscience.

[33]  T. Takano,et al.  An astrocytic basis of epilepsy , 2005, Nature Medicine.

[34]  Anne Giersch,et al.  Is Schizophrenia a Disorder of Consciousness? Experimental and Phenomenological Support for Anomalous Unconscious Processing , 2017, Front. Psychol..

[35]  T. Fellin,et al.  Astrocytes coordinate synaptic networks: balanced excitation and inhibition. , 2006, Physiology.

[36]  N. Chen,et al.  Gap Junction Dysfunction in the Prefrontal Cortex Induces Depressive-Like Behaviors in Rats , 2012, Neuropsychopharmacology.

[37]  Quantum Physics Relevance to Psychiatry , 2009 .

[38]  J. Parnas,et al.  Disordered Self in the Schizophrenia Spectrum: A Clinical and Research Perspective , 2014, Harvard review of psychiatry.

[39]  Alfredo Pereira,et al.  Astrocytes and human cognition: Modeling information integration and modulation of neuronal activity , 2010, Progress in Neurobiology.

[40]  S. Oliet,et al.  Gliotransmitters Travel in Time and Space , 2014, Neuron.

[41]  P. Agostinho,et al.  Depression as a Glial-Based Synaptic Dysfunction , 2016, Front. Cell. Neurosci..

[42]  R. Myers,et al.  Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[43]  Baoman Li,et al.  Targeting astrocytes in major depression , 2015, Expert review of neurotherapeutics.