Near-infrared light as a possible treatment option for Parkinson's disease and laser eye injury

Studies in our laboratory demonstrate that the action spectrum for stimulation of cytochrome oxidase activity and cellular ATP parallels the near-infrared absorption spectrum of cytochrome oxidase and that 660-680 nm irradiation upregulates cytochrome oxidase activity in cultured neurons. Treatment with nearinfrared light augments cellular energy production and neuronal viability following mitochondrial injury linking the actions of red to near-infrared light on mitochondrial metabolism in vitro and cell injury in vivo. NIR light treatment represents an innovative therapeutic approach for disease processes in which mitochondrial dysfunction is postulated to play a role including Parkinson's disease, laser eye injury and Age-related macular degeneration.

[1]  G. Polunin,et al.  [Pathogenesis of age-related macular degeneration]. , 2006, Vestnik oftalmologii.

[2]  Noel T. Whelan,et al.  Effect of NASA light-emitting diode irradiation on wound healing. , 2001, Journal of clinical laser medicine & surgery.

[3]  R P Franke,et al.  Biostimulatory windows in low-intensity laser activation: lasers, scanners, and NASA's light-emitting diode array system. , 2001, Journal of clinical laser medicine & surgery.

[4]  B. Beauvoit,et al.  Correlation between the light scattering and the mitochondrial content of normal tissues and transplantable rodent tumors. , 1995, Analytical biochemistry.

[5]  R Lubart,et al.  Effects of visible and near-infrared lasers on cell cultures. , 1992, Journal of photochemistry and photobiology. B, Biology.

[6]  Britton Chance,et al.  Photobiomodulation Directly Benefits Primary Neurons Functionally Inactivated by Toxins , 2005, Journal of Biological Chemistry.

[7]  A. Lang,et al.  Parkinson's disease. First of two parts. , 1998, The New England journal of medicine.

[8]  M. Beal Mitochondria, Oxidative Damage, and Inflammation in Parkinson's Disease , 2003, Annals of the New York Academy of Sciences.

[9]  R J Lanzafame,et al.  THE EFFECT OF LASER IRRADIATION ON THE RELEASE OF bFGF FROM 3T3 FIBROBLASTS , 1994, Photochemistry and photobiology.

[10]  Amir Oron,et al.  Attenuation of infarct size in rats and dogs after myocardial infarction by low‐energy laser irradiation , 2001, Lasers in surgery and medicine.

[11]  Rina Das,et al.  Effect of NASA light-emitting diode irradiation on molecular changes for wound healing in diabetic mice. , 2003, Journal of clinical laser medicine & surgery.

[12]  T. Sherer,et al.  Environment, Mitochondria, and Parkinson's Disease , 2002, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[13]  Michael Belkin,et al.  Temporal parameters of low energy laser irradiation for optimal delay of post-traumatic degeneration of rat optic nerve , 1989, Brain Research.

[14]  M. Belkin,et al.  Laser eye injuries. , 2000, Survey of ophthalmology.

[15]  M. Beal,et al.  Parkinson's disease. , 2007, Human molecular genetics.

[16]  T. Kitai,et al.  Contribution of the mitochondrial compartment to the optical properties of the rat liver: a theoretical and practical approach. , 1994, Biophysical journal.

[17]  W. Hauswirth,et al.  Toward a higher fidelity model of AMD. , 2008, Advances in experimental medicine and biology.

[18]  N. Wood,et al.  Expanding insights of mitochondrial dysfunction in Parkinson's disease , 2006, Nature Reviews Neuroscience.

[19]  H. T. Whelan,et al.  Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity , 2008, Neuroscience.

[20]  Noel T. Whelan,et al.  NASA light-emitting diodes for the prevention of oral mucositis in pediatric bone marrow transplant patients. , 2002, Journal of clinical laser medicine & surgery.

[21]  C M Cobb,et al.  Biostimulation of wound healing by low-energy laser irradiation. A review. , 1996, Journal of clinical periodontology.

[22]  Jeffrey H Kordower,et al.  The role of alpha-synuclein in Parkinson's disease: insights from animal models. , 2003, Nature reviews. Neuroscience.

[23]  Andrew B West,et al.  Molecular pathophysiology of Parkinson's disease. , 2005, Annual review of neuroscience.

[24]  L. Tremblay,et al.  Experimental Models of Parkinson’s Disease , 2002, Annales pharmaceutiques francaises.

[25]  Noel T. Whelan,et al.  Therapeutic photobiomodulation for methanol-induced retinal toxicity , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[26]  S. Ryan,et al.  Subretinal neovascularization. Natural history of an experimental model. , 1982, Archives of ophthalmology.

[27]  T. Sherer,et al.  Response: Parkinson's disease, pesticides and mitochondrial dysfunction , 2001, Trends in Neurosciences.

[28]  D. Henshel,et al.  670 nanometer light treatment attenuates dioxin toxicity in the developing chick embryo , 2006, Journal of biochemical and molecular toxicology.

[29]  T. Karu,et al.  Primary and secondary mechanisms of action of visible to near-IR radiation on cells. , 1999, Journal of photochemistry and photobiology. B, Biology.

[30]  Todd B. Sherer,et al.  Chronic systemic pesticide exposure reproduces features of Parkinson's disease , 2000, Nature Neuroscience.

[31]  T. Dawson,et al.  Molecular Pathways of Neurodegeneration in Parkinson's Disease , 2003, Science.

[32]  S Nioka,et al.  Time-resolved spectroscopy of hemoglobin and myoglobin in resting and ischemic muscle. , 1988, Analytical biochemistry.

[33]  M. Wong-Riley,et al.  Light-emitting diode treatment reverses the effect of TTX on cytochrome oxidase in neurons , 2001, Neuroreport.

[34]  Todd B. Sherer,et al.  Subcutaneous Rotenone Exposure Causes Highly Selective Dopaminergic Degeneration and α-Synuclein Aggregation , 2003, Experimental Neurology.

[35]  Tiina I. Karu,et al.  The science of low-power laser therapy , 1998 .