Inflammasome activation plays an important role in the development of spontaneous colitis

[1]  K. Maloy,et al.  Type I IFNs Regulate Effector and Regulatory T Cell Accumulation and Anti-Inflammatory Cytokine Production during T Cell–Mediated Colitis , 2013, The Journal of Immunology.

[2]  Dianqing Wu,et al.  Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway , 2013, Proceedings of the National Academy of Sciences.

[3]  K. Mills,et al.  The role of inflammasome‐derived IL‐1 in driving IL‐17 responses , 2013, Journal of leukocyte biology.

[4]  Burkhard Becher,et al.  IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+ Th17 cells , 2012, The Journal of experimental medicine.

[5]  P. Vandenabeele,et al.  Interferon-β Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome , 2012, Science Signaling.

[6]  G. Núñez,et al.  Sensing and reacting to microbes through the inflammasomes , 2012, Nature Immunology.

[7]  K. Fitzgerald,et al.  Regulation of inflammasome signaling , 2012, Nature Immunology.

[8]  E. Elinav,et al.  Inflammasomes: far beyond inflammation , 2012, Nature Immunology.

[9]  Richard A. Flavell,et al.  Inflammasomes in health and disease , 2012, Nature.

[10]  Richard A. Flavell,et al.  Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity , 2012, Nature.

[11]  G. Cheng,et al.  Type I IFN Promotes IL-10 Production from T Cells to Suppress Th17 Cells and Th17-Associated Autoimmune Inflammation , 2011, PLoS ONE.

[12]  C. Klein,et al.  IL‐10 and IL‐10 receptor defects in humans , 2011, Annals of the New York Academy of Sciences.

[13]  M. Takenaka,et al.  Neonatal Fc receptor for IgG (FcRn) expressed in the gastric epithelium regulates bacterial infection in mice , 2011, Mucosal Immunology.

[14]  M. Takenaka,et al.  IFN-γ plays an essential role in the pathogenesis of gastric lymphoid follicles formation caused by Helicobacter suis infection. , 2011, FEMS immunology and medical microbiology.

[15]  Hao Xu,et al.  The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus , 2011, Nature.

[16]  J. Tschopp,et al.  The inflammasome: an integrated view , 2011, Immunological reviews.

[17]  M. Swartz.  A decade later. , 2011, Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners.

[18]  M. Takenaka,et al.  Helicobacter suis KB1 derived from pig gastric lymphoid follicles induces the formation of gastric lymphoid follicles in mice through the activation of B cells and CD4 positive cells. , 2011, Microbes and infection.

[19]  Maria Papatriantafyllou.  Mucosal immunology: Inflammasome shapes the microbiota , 2011, Nature Reviews Immunology.

[20]  Rob Knight,et al.  Interleukin-1β (IL-1β) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis , 2011, Gut.

[21]  Yan Li,et al.  NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis , 2011, Inflammatory bowel diseases.

[22]  Richard A. Flavell,et al.  NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis , 2011, Cell.

[23]  Pedro Romero,et al.  Type I interferon inhibits interleukin-1 production and inflammasome activation. , 2011, Immunity.

[24]  A. Kaser,et al.  Crohn's disease: NOD2, autophagy and ER stress converge , 2011, Gut.

[25]  T. Azuma,et al.  Helicobacter heilmannii can induce gastric lymphoid follicles in mice via a Peyer's patch-independent pathway. , 2010, FEMS immunology and medical microbiology.

[26]  T. Macdonald,et al.  IL‐23/IL‐17 axis in IBD , 2010, Inflammatory bowel diseases.

[27]  T. Meyer,et al.  The chemokine receptor CXCR5 is pivotal for ectopic mucosa-associated lymphoid tissue neogenesis in chronic Helicobacter pylori-induced inflammation , 2010, Journal of Molecular Medicine.

[28]  H. Herfarth,et al.  The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer , 2010, The Journal of experimental medicine.

[29]  J. Tschopp,et al.  Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome , 2010, Gut.

[30]  Elke Cario,et al.  Toll-like receptors in inflammatory bowel diseases: A decade later , 2010, Inflammatory bowel diseases.

[31]  M. Kastan,et al.  The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. , 2010, Immunity.

[32]  N. Beauchemin,et al.  Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. , 2010, Immunity.

[33]  Gisen Kim,et al.  Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis , 2009, Nature Immunology.

[34]  Dan R. Littman,et al.  Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria , 2009, Cell.

[35]  K. Mills,et al.  Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. , 2009, Immunity.

[36]  Judy H. Cho,et al.  Interleukin-23/Th17 pathways and inflammatory bowel disease. , 2009, Inflammatory bowel diseases.

[37]  T. Kinashi,et al.  CXCL13 production by an established lymph node stromal cell line via lymphotoxin-beta receptor engagement involves the cooperation of multiple signaling pathways. , 2009, International immunology.

[38]  F. Haesebrouck,et al.  Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health , 2009, Clinical Microbiology Reviews.

[39]  F. Caprioli,et al.  Th17 immune response in IBD: A new pathogenic mechanism. , 2008, Journal of Crohn's & colitis.

[40]  S. Brant,et al.  Contributions of IBD5, IL23R, ATG16L1, and NOD2 to Crohn's disease risk in a population‐based case‐control study: Evidence of gene–gene interactions , 2008, Inflammatory bowel diseases.

[41]  S. Seok,et al.  Gastric lesions and immune responses caused by long-term infection with Helicobacter heilmannii in C57BL/6 mice. , 2008, Journal of comparative pathology.

[42]  H. Tilg,et al.  XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease , 2008, Cell.

[43]  Hiroshi Kiyono,et al.  Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5 , 2008, Nature Immunology.

[44]  G. Cheng,et al.  The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. , 2008, The Journal of clinical investigation.

[45]  S. Akira,et al.  Deletion of TLR5 results in spontaneous colitis in mice. , 2007, The Journal of clinical investigation.

[46]  D. Maes,et al.  Prevalence of ‘Candidatus Helicobacter suis’ in pigs of different ages , 2007, Veterinary Record.

[47]  A. Plebani,et al.  Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL. , 2007, Immunity.

[48]  Genhong Cheng,et al.  Cutting Edge: Involvement of the Type I IFN Production and Signaling Pathway in Lipopolysaccharide-Induced IL-10 Production1 , 2007, The Journal of Immunology.

[49]  T. Hibi,et al.  “Candidatus Helicobacter heilmannii” from a Cynomolgus Monkey Induces Gastric Mucosa-Associated Lymphoid Tissue Lymphomas in C57BL/6 Mice , 2006, Infection and Immunity.

[50]  F. Aloisi,et al.  Lymphoid neogenesis in chronic inflammatory diseases , 2006, Nature Reviews Immunology.

[51]  J. Woof,et al.  Mucosal immunoglobulins , 2005, Immunological reviews.

[52]  K. Sano,et al.  Helicobacter heilmannii infection: Clinical, endoscopic and histopathological features in Japanese patients , 2005, Pathology international.

[53]  G. Valesini,et al.  Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjögren's syndrome. , 2005, Arthritis and rheumatism.

[54]  Keiichiro Suzuki,et al.  Two distinctive pathways for recruitment of naive and primed IgM+ B cells to the gut lamina propria. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[55]  B. Zheng,et al.  CXCL13 neutralization reduces the severity of collagen-induced arthritis. , 2005, Arthritis and rheumatism.

[56]  T. Pizarro,et al.  Commentary: The role of the IL‐18 system and other members of the IL‐1R/TLR superfamily in innate mucosal immunity and the pathogenesis of inflammatory bowel disease: friend or foe? , 2004, European journal of immunology.

[57]  A. Lee,et al.  Gastric B‐cell mucosa‐associated lymphoid tissue (MALT) lymphoma in an animal model of ‘Helicobacter heilmannii’ infection , 2004, The Journal of pathology.

[58]  D. Roopenian,et al.  Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. , 2004, Immunity.

[59]  M. Wiedmann,et al.  Evaluation of “Helicobacter heilmannii” Subtypes in the Gastric Mucosas of Cats and Dogs , 2004, Journal of Clinical Microbiology.

[60]  F. Martinon,et al.  NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. , 2004, Immunity.

[61]  P. Vandamme,et al.  Multiplex PCR Assay for Differentiation of Helicobacter felis, H. bizzozeronii, and H. salomonis , 2004, Journal of Clinical Microbiology.

[62]  B. Serafini,et al.  Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis , 2004, Journal of Neuroimmunology.

[63]  J. Fox,et al.  Helicobacter-Induced Chronic Active Lymphoid Aggregates Have Characteristics of Tertiary Lymphoid Tissue , 2003, Infection and Immunity.

[64]  E. S. Baekkevold,et al.  B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue , 2002, Gut.

[65]  M. Wahren-Herlenius,et al.  Expression of the B Cell‐Attracting Chemokine CXCL13 in the Target Organ and Autoantibody Production in Ectopic Lymphoid Tissue in the Chronic Inflammatory Disease Sjögren's Syndrome , 2002, Scandinavian journal of immunology.

[66]  M. Salmon,et al.  Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjögren's syndrome. , 2001, Arthritis and rheumatism.

[67]  G. Fantuzzi,et al.  IL-1β-converting enzyme (caspase-1) in intestinal inflammation , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[68]  T. Honjo,et al.  In situ class switching and differentiation to IgA-producing cells in the gut lamina propria , 2001, Nature.

[69]  W. O'Fallon,et al.  Lymphoid Neogenesis in Rheumatoid Synovitis1 , 2001, The Journal of Immunology.

[70]  Mourad Sahbatou,et al.  Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease , 2001, Nature.

[71]  D. Nicolae,et al.  A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease , 2001, Nature.

[72]  C. Moskaluk,et al.  Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease. , 2001, The Journal of clinical investigation.

[73]  F. Fernández-Bañares,et al.  Accuracy of an enzyme immunoassay for the detection of Helicobacter pylori in stool specimens in the diagnosis of infection and posttreatment check-up , 2000, American Journal of Gastroenterology.

[74]  Jason G. Cyster,et al.  A chemokine-driven positive feedback loop organizes lymphoid follicles , 2000, Nature.

[75]  M. Stolte,et al.  Helicobacter heilmannii-associated primary gastric low-grade MALT lymphoma: complete remission after curing the infection. , 2000, Gastroenterology.

[76]  D. Hanahan,et al.  BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis. , 2000, Immunity.

[77]  G. Kollias,et al.  Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic cell precursors into splenic follicles. , 2000, Cellular immunology.

[78]  T. Kita,et al.  Induction and maintenance of immune effector cells in the gastric tissue of mice orally immunized to Helicobacter pylori requires salivary glands. , 2000, Gastroenterology.

[79]  K. Okazaki,et al.  Induction of Follicular Gastritis following Postthymectomy Autoimmune Gastritis in Helicobacter pylori-Infected BALB/c Mice , 2000, Infection and Immunity.

[80]  L. Mazzucchelli,et al.  BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma. , 1999, The Journal of clinical investigation.

[81]  P. Vandamme,et al.  'Candidatus Helicobacter suis', a gastric helicobacter from pigs, and its phylogenetic relatedness to other gastrospirilla. , 1999, International journal of systematic bacteriology.

[82]  M. Matsumoto,et al.  Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting. , 1999, The journal of medical investigation : JMI.

[83]  K. Matsushima,et al.  Active participation of CCR5(+)CD8(+) T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease. , 1999, The Journal of clinical investigation.

[84]  N. Harindranath,et al.  CD40 ligand and appropriate cytokines induce switching to IgG, IgA, and IgE and coordinated germinal center and plasmacytoid phenotypic differentiation in a human monoclonal IgM+IgD+ B cell line. , 1998, Journal of immunology.

[85]  Jason G. Cyster,et al.  A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1 , 1998, Nature.

[86]  M. Baggiolini,et al.  B Cell–attracting Chemokine 1, a Human CXC Chemokine Expressed in Lymphoid Tissues, Selectively Attracts B Lymphocytes via BLR1/CXCR5 , 1998, The Journal of experimental medicine.

[87]  E. Wolf,et al.  A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen , 1996, Cell.

[88]  C. Fiocchi,et al.  Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation. , 1995, Journal of immunology.

[89]  R Fischer,et al.  Helicobacter pylori gastritis and primary gastric non-Hodgkin's lymphomas. , 1994, Journal of clinical pathology.

[90]  K. Rajewsky,et al.  Interleukin-10-deficient mice develop chronic enterocolitis , 1993, Cell.

[91]  R. Macdermott,et al.  Enhand secretion of tumour necrosis factor‐alpha, IL‐6, and IL‐1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease , 1993 .

[92]  M. Stolte,et al.  Prevalence of lymphoid follicles and aggregates in Helicobacter pylori gastritis in antral and body mucosa. , 1993, Journal of clinical pathology.

[93]  D. Graham,et al.  Gastric lymphoid follicles in Helicobacter pylori infection: frequency, distribution, and response to triple therapy. , 1993, Human pathology.

[94]  P. Isaacson,et al.  Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma , 1991, The Lancet.

[95]  G. Friedman,et al.  Helicobacter pylori infection and the risk of gastric carcinoma. , 1991, The New England journal of medicine.

[96]  P. Simon,et al.  Role of interleukin 1 in inflammatory bowel disease--enhanced production during active disease. , 1990, Gut.

[97]  N. Yamaguchi,et al.  Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production , 1989, The Journal of experimental medicine.

[98]  T. Hirano,et al.  Interleukins and IgA synthesis. Human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells , 1989, The Journal of experimental medicine.

[99]  Ruth E. Hartley,et al.  An integrated view. , 1973 .

[100]  M. Rehm,et al.  A Decade Later: Looking at the Past while Sketching the Future of ICH through the Tripartite Digitisation Model , 2015 .

[101]  Judy H. Cho,et al.  Materials for : Host-microbe interactions shape genetic risk for inflammatory bowel disease , 2012 .

[102]  Mathieu Lemire,et al.  Common variants in the NLRP3 region contribute to Crohn's disease susceptibility , 2009, Nature Genetics.

[103]  G. Fantuzzi,et al.  IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[104]  D. Chaplin,et al.  Development and maturation of secondary lymphoid tissues. , 1999, Annual review of immunology.

[105]  J. Cyster,et al.  Chemokines and B-cell homing to follicles. , 1999, Current topics in microbiology and immunology.

[106]  M. McAlindon,et al.  Expression of interleukin 1 â and interleukin 1 â converting enzyme by intestinal macrophages in health and inflammatory bowel disease , 1998 .

[107]  M. Stolte,et al.  Animal reservoirs in the transmission of Helicobacter heilmannii. Results of a questionnaire-based study. , 1998, Scandinavian journal of gastroenterology.

[108]  N. Harindranath,et al.  CD 40 Ligand and Appropriate Cytokines Induce Switching to IgG , IgA , and IgE and Coordinated Germinal Center and Plasmacytoid Phenotypic Differentiation in a Human Monoclonal IgM 1 IgD 1 B Cell Line 1 , 1998 .

[109]  M. Tsuneyoshi,et al.  Helicobacter pylori and primary gastric lymphoma , 1997, Cancer.

[110]  M. Stolte,et al.  Helicobacter heilmannii (formerly Gastrospirillum hominis) gastritis: an infection transmitted by animals? , 1994, Scandinavian journal of gastroenterology.

[111]  S. Schreiber,et al.  Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease. , 1993, Clinical and experimental immunology.

[112]  園田 英一朗.  Transforming growth factor β induces IgA production and acts additively with interleukin 5 for IgA production , 1992 .

[113]  T. Hirano,et al.  INTERLEUKINS AND IgA SYNTHESIS , 1989 .

[114]  B. Rathbone,et al.  Immune response of the gastric mucosa to Campylobacter pylori. , 1988, Scandinavian journal of gastroenterology. Supplement.