Combined effects of methotrexate and 5-fluoropyrimidine on human breast cancer cells in serum-free culture.

[1]  R. Fisher,et al.  Advanced ovarian adenocarcinoma. A prospective clinical trial of melphalan (L-PAM) versus combination chemotherapy. , 1978, The New England journal of medicine.

[2]  M. Lippman,et al.  Growth of a human breast cancer cell line in serum-free hormone-supplemented medium. , 1978, Cancer research.

[3]  S. O’Brien,et al.  Establishment and characterization of three new continuous cell lines derived from human breast carcinomas. , 1978, Cancer research.

[4]  G. Grindey,et al.  Potentiation of the antitumor activity of methotrexate by concurrent infusion of thymidine. , 1978, Cancer research.

[5]  D. Santi,et al.  Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[6]  J. White,et al.  A basis for fluoropyrimidine-induced antagonism to methotrexate in Ehrlich ascites tumor cells in vitro. , 1978, Cancer research.

[7]  C. Osborne,et al.  Correlation among insulin binding, degradation, and biological activity in human breast cancer cells in long-term tissue culture. , 1978, Cancer research.

[8]  Y. Cheng,et al.  Human thymidylate synthetase derived from blast cells of patients with acture myelocytic leukemia. Purification and chracterization. , 1977, The Journal of biological chemistry.

[9]  D. Zaharko,et al.  Relative biochemical aspects of low and high doses of methotrexate in mice. , 1977, Cancer research.

[10]  Yeu‐Tsu N. Lee,et al.  Adjuvant postoperative chemotherapy with 5‐fluorouracil and methotrexate: Effect of schedule of administration on metastasis of 13762 mammary adenocarcinoma , 1977, Journal of surgical oncology.

[11]  J. Bertino,et al.  Schedule-dependent antitumor effects of methotrexate and 5-fluorouracil. , 1977, Cancer research.

[12]  R. Jackson,et al.  Enzyme pattern directed chemotherapy. The effects of combinations of methotrexate, 5-fluorodeoxyuridine and thymidine on rat hepatoma cells in vitro. , 1976, Biochemical pharmacology.

[13]  B. Chabner,et al.  The reversal of methotrexate cytotoxicity to mouse bone marrow cells by leucovorin and nucleosides. , 1976, Cancer research.

[14]  G. Bonadonna,et al.  Combination chemotherapy as an adjuvant treatment in operable breast cancer. , 1976, The New England journal of medicine.

[15]  G. Maley,et al.  Factors affecting substrate binding in Lactobacillus casei thymidylate synthetase as studied by equilibrium dialysis. , 1976, Biochemistry.

[16]  R. K. Knight,et al.  Discussion Summary: Alternatives for Continued Progress* , 1985, Environmental health perspectives.

[17]  R. Mitchell,et al.  The failure of methotrexate to inhibit chicken fibroblast proliferation in a serum-containing culture medium. , 1975, Cancer research.

[18]  P. Otis,et al.  Combination chemotherapy in metastatic carcinoma of the breast Results with a three‐drug combination , 1975, Cancer.

[19]  P. Engstrom,et al.  An effective low‐dose intermittent cyclophosphamide, methotrexate, and 5‐fluorouracil treatment regimen for metastatic breast cancer , 1975, Cancer.

[20]  E. Frei,et al.  The reversal of methotrexate toxicity by thymidine with maintenance of antitumour effects , 1975, Nature.

[21]  M. Tattersall,et al.  Factors determining cell sensitivity to methotrexate: studies of folate and deoxyribonucleoside triphosphate pools in five mammalian cell lines. , 1974, European journal of cancer.

[22]  D. Santi,et al.  Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate. , 1974, Biochemistry.

[23]  T. A. Connors,et al.  Combination chemotherapy: the interaction of methotrexate and 5-fluorouracil. , 1973, European journal of cancer.

[24]  K. Sanford,et al.  Influence of oxygen and culture media on plating efficiency of some mammalian tissue cells. , 1972, Journal of the National Cancer Institute.

[25]  D. Santi,et al.  5-Fluoro-2'-deoxyuridylate: covalent complex with thymidylate synthetase. , 1972, Proceedings of the National Academy of Sciences of the United States of America.

[26]  W. Hryniuk.  Purineless death as a link between growth rate and cytotoxicity by methotrexate. , 1972, Cancer research.

[27]  R. Rueckert,et al.  Studies on unbalanced growth in tissue culture. I. Induction and consequences of thymidine deficiency. , 1960, Cancer research.

[28]  M. L. Eidinoff,et al.  Growth inhibition of a human tumor cell strain by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine; reversal studies. , 1958, Cancer research.

[29]  M. Hakala.  Prevention of toxicity of amethopterin for sarcoma-180 cells in tissue culture. , 1957, Science.

[30]  G. Hitchings,et al.  Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites. , 1954, The Journal of biological chemistry.