Mitochondrial thioredoxin-2 from Manila clam (Ruditapes philippinarum) is a potent antioxidant enzyme involved in antibacterial response.

[1]  Ian R. Wickersham,et al.  Production of glycoprotein-deleted rabies viruses for monosynaptic tracing and high-level gene expression in neurons , 2010, Nature Protocols.

[2]  P. Soudant,et al.  Hemocytes of the carpet shell clam (Ruditapes decussatus) and the Manila clam (Ruditapes philippinarum): Current knowledge and future prospects , 2009 .

[3]  Xiaoyan Song,et al.  A thioredoxin with antioxidant activity identified from Eriocheir sinensis. , 2009, Fish & shellfish immunology.

[4]  E. Kalinina,et al.  Involvement of thio-, peroxi-, and glutaredoxins in cellular redox-dependent processes , 2008, Biochemistry (Moscow).

[5]  N. Maulik,et al.  Emerging potential of thioredoxin and thioredoxin interacting proteins in various disease conditions. , 2008, Biochimica et biophysica acta.

[6]  Li Li,et al.  The manganese superoxide dismutase gene in bay scallop Argopecten irradians: cloning, 3D modelling and mRNA expression. , 2008, Fish & shellfish immunology.

[7]  K. Korsnes,et al.  Vibrio tapetis-like strain isolated from introduced Manila clams Ruditapes philippinarum showing symptoms of brown ring disease in Norway. , 2008, Diseases of aquatic organisms.

[8]  R. Sotelo-Mundo,et al.  Shrimp thioredoxin is a potent antioxidant protein. , 2008, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[9]  A. Holmgren,et al.  Thioredoxins and glutaredoxins as facilitators of protein folding. , 2008, Biochimica et biophysica acta.

[10]  Jehee Lee,et al.  Mitochondrial thioredoxin-2 from disk abalone (Haliotis discus discus): molecular characterization, tissue expression and DNA protection activity of its recombinant protein. , 2008, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

[11]  M. Valko,et al.  Free radicals, metals and antioxidants in oxidative stress-induced cancer. , 2006, Chemico-biological interactions.

[12]  F. Meyskens,et al.  Redox regulation by intrinsic species and extrinsic nutrients in normal and cancer cells. , 2005, Annual review of nutrition.

[13]  Peter Clote,et al.  DiANNA: a web server for disulfide connectivity prediction , 2005, Nucleic Acids Res..

[14]  R. Schirmer,et al.  Comparative structural analysis of oxidized and reduced thioredoxin from Drosophila melanogaster. , 2005, Journal of molecular biology.

[15]  W. Hou,et al.  Active recombinant thioredoxin h protein with antioxidant activities from sweet potato (Ipomoea batatas [L.] Lam Tainong 57) storage roots. , 2004, Journal of agricultural and food chemistry.

[16]  Dean P. Jones,et al.  Extracellular thiols and thiol/disulfide redox in metabolism. , 2004, Annual review of nutrition.

[17]  Sudhir Kumar,et al.  MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment , 2004, Briefings Bioinform..

[18]  A. Loukas,et al.  Functional expression and characterization of Echinococcus granulosus thioredoxin peroxidase suggests a role in protection against oxidative damage. , 2004, Gene.

[19]  M. Samoilov,et al.  The Mitochondrial Antioxidants Thioredoxin-2 and Mn-Superoxide Dismutase Are Involved in the Mechanisms of Brain Hypoxic Tolerance , 2002, Doklady Biological Sciences.

[20]  Dean P. Jones,et al.  Overexpressed Human Mitochondrial Thioredoxin Confers Resistance to Oxidant-induced Apoptosis in Human Osteosarcoma Cells* , 2002, The Journal of Biological Chemistry.

[21]  Xuehui Chen,et al.  Crystal structure of the catalytic domain of a human thioredoxin-like protein. , 2002, European journal of biochemistry.

[22]  Y. Yamaguchi-Iwai,et al.  Thioredoxin‐2 (TRX‐2) is an essential gene regulating mitochondria‐dependent apoptosis , 2002, The EMBO journal.

[23]  G von Heijne,et al.  Prediction of organellar targeting signals. , 2001, Biochimica et biophysica acta.

[24]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[25]  R. Schirmer,et al.  Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster. , 2001, Science.

[26]  J. Matés,et al.  Antioxidant enzymes and human diseases. , 1999, Clinical biochemistry.

[27]  J. Pedrajas,et al.  Identification and Functional Characterization of a Novel Mitochondrial Thioredoxin System in Saccharomyces cerevisiae * , 1999, The Journal of Biological Chemistry.

[28]  A. Miranda-Vizuete,et al.  Cloning, Expression, and Characterization of a NovelEscherichia coli Thioredoxin* , 1997, The Journal of Biological Chemistry.

[29]  J. Gustafsson,et al.  Cloning and Expression of a Novel Mammalian Thioredoxin* , 1997, The Journal of Biological Chemistry.

[30]  P Vincens,et al.  Computational method to predict mitochondrially imported proteins and their targeting sequences. , 1996, European journal of biochemistry.

[31]  B. Halliwell,et al.  Antioxidants in human health and disease. , 1996, Annual review of nutrition.

[32]  R A Sayle,et al.  RASMOL: biomolecular graphics for all. , 1995, Trends in biochemical sciences.

[33]  R. Sitia,et al.  High rates of thioredoxin secretion correlate with growth arrest in hepatoma cells. , 1995, Cancer research.

[34]  J. Thompson,et al.  CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. , 1994, Nucleic acids research.

[35]  S. Rhee,et al.  Thioredoxin-dependent peroxide reductase from yeast. , 1994, The Journal of biological chemistry.

[36]  R. Anderson Hemocyte-derived reactive oxygen intermediate production in four bivalve mollusks. , 1994, Developmental and comparative immunology.

[37]  J. Yodoi,et al.  Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62 , 1992 .

[38]  J. Hendrick,et al.  Survey of amino-terminal proteolytic cleavage sites in mitochondrial precursor proteins: leader peptides cleaved by two matrix proteases share a three-amino acid motif. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[39]  B. Slatko,et al.  An Escherichia coli vector to express and purify foreign proteins by fusion to and separation from maltose-binding protein. , 1988, Gene.

[40]  J. Wood,et al.  The role of thioredoxin reductase in the reduction of free radicals at the surface of the epidermis. , 1986, Biochemical and biophysical research communications.

[41]  A. Holmgren,et al.  Thioredoxin catalyzes the reduction of insulin disulfides by dithiothreitol and dihydrolipoamide. , 1979, The Journal of biological chemistry.

[42]  M. M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[43]  P. Reade Phagocytosis in invertebrates. , 1968, The Australian journal of experimental biology and medical science.

[44]  Jehee Lee,et al.  Cytosolic thioredoxin from Ruditapes philippinarum: molecular cloning, characterization, expression and DNA protection activity of the recombinant protein. , 2012, Developmental and comparative immunology.

[45]  Jianmin Zhao,et al.  Cloning and characterization of allograft inflammatory factor-1 (AIF-1) from Manila clam Venerupis philippinarum. , 2011, Fish & shellfish immunology.

[46]  Xiao-Fan Zhao,et al.  A thioredoxin response to the WSSV challenge on the Chinese white shrimp, Fenneropenaeus chinensis. , 2010, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[47]  Bing Wang,et al.  The mitochondrial manganese superoxide dismutase gene in Chinese shrimp Fenneropenaeus chinensis: cloning, distribution and expression. , 2007, Developmental and comparative immunology.

[48]  Yi-Zheng Zhang,et al.  Molecular cloning and characterization of a peroxiredoxin from Phanerochaete chrysosporium. , 2005, Cellular & molecular biology letters.

[49]  A. Segal,et al.  How neutrophils kill microbes. , 2005, Annual review of immunology.

[50]  G. Powis,et al.  Properties and biological activities of thioredoxins. , 2001, Annual review of biophysics and biomolecular structure.

[51]  A. Bairoch,et al.  The PROSITE database, its status in 1997 , 1997, Nucleic Acids Res..