Adaptive control system for blood glucose regulation

An adaptive scheme for blood glucose regulation is investigated via model-based approaches. The system has the capability of compensating in an on-line manner individual differences and parameter variations in the blood glucose regulation of diabetic subjects. The adaptive control algorithm consists of two types of controllers: a self-tuning regulator for adaptively performing model-matching to the reference model, and an error feedback controller to minimise the output error between the actual glucose level and the desired decreasing profile specified by physicians. It is shown through numerical simulations and animal experiments that in the presence of large parameter variations and disturbances due to food intake, the control algorithm can work efficiently compared to a conventional control algorithm with fixed parameters.

[1]  E. Kraegen,et al.  Control of blood glucose in diabetics using an artificial pancreas. , 1977, Australian and New Zealand journal of medicine.

[2]  W. Zingg,et al.  An Artificial Endocrine Pancreas , 1974, Diabetes.

[3]  A. Albisser,et al.  Devices for the control of diabetes mellitus , 1979, Proceedings of the IEEE.

[4]  A E Lambert,et al.  Determination of Insulin Requirements in Brittle Diabetic Patients by the Artificial Pancreas , 1978, Diabetes.

[5]  Akira Sano,et al.  Optimal design of preview control system described by input‐output representation , 1982 .

[6]  Michael A. Budin,et al.  A New Approach to System Identification and State Estimation , 1972, IEEE Trans. Syst. Man Cybern..

[7]  Akira Sano,et al.  Optimal Control System for Blood Glucose Regulation , 1981 .

[8]  A M Albisser,et al.  A circulation and organs model for insulin dynamics. , 1979, The American journal of physiology.

[9]  A H Clemens,et al.  Closed-loop and Open-loop Devices for Blood Glucose Control in Normal and Diabetic Subjects , 1978, Diabetes.

[10]  Claudio Cobelli,et al.  An integrated mathematical model of the dynamics of blood glucose and its hormonal control , 1982 .

[11]  A H Clemens,et al.  The artificial beta cell--a continuous control of blood sugar by external regulation of insulin infusion (glucose controlled insulin infusion system). , 1974, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[12]  T Murata,et al.  [The development of self-adaptive control algorithm for blood glucose concentration for an artificial beta cell--adaptive blood glucose control in diabetic ketosis and ketoacidosis]. , 1982, Nihon Naibunpi Gakkai zasshi.

[13]  L C Gatewood,et al.  Mathematical analysis of blood glucose and plasma insulin responses to insulin infusion in healthy and diabetic subjects. , 1973, Computers in biology and medicine.

[14]  B. Zinman,et al.  Normalization of Glycemia in Diabetics During Meals with Insulin and Glucagon Delivery by the Artificial Pancreas , 1977, Diabetes.

[15]  M Shichiri,et al.  [Blood glucose regulation in the depancreatized dogs by the artificial beta cell (author's transl)]. , 1978, Iyo denshi to seitai kogaku. Japanese journal of medical electronics and biological engineering.

[16]  B. Egardt.  Stability analysis of discrete-time adaptive control schemes , 1980 .

[17]  E. Cerasi,et al.  A Mathematical Model for the Glucose Induced Insulin Release in Man , 1974, European journal of clinical investigation.

[18]  B F Clarke,et al.  Control of blood glucose in labour. , 1977, British medical journal.

[19]  E. Kraegen,et al.  Carrier solutions for low-level intravenous insulin infusion. , 1975, British medical journal.