Ultraviolet light-mediated drug delivery: Principles, applications, and challenges.

UV light has been extensively employed in drug delivery because of its versatility, ease of manipulation, and ability to induce chemical changes on the therapeutic carrier. Here we review the mechanisms by which UV light affects drug delivery systems. We will present the challenges facing UV-induced drug delivery and some of the proposed solutions.

[1]  Carmen Alvarez-Lorenzo,et al.  Light‐sensitive Intelligent Drug Delivery Systems † , 2009, Photochemistry and photobiology.

[2]  D. Yan,et al.  Photo-responsive polymeric micelles. , 2014, Soft matter.

[3]  Yasuhiro Matsumura,et al.  Toxic effects of ultraviolet radiation on the skin. , 2004, Toxicology and applied pharmacology.

[4]  Eric C. Carnes,et al.  Mesoporous silica nanoparticle nanocarriers: biofunctionality and biocompatibility. , 2013, Accounts of chemical research.

[5]  Kemin Wang,et al.  A light-responsive reversible molecule-gated system using thymine-modified mesoporous silica nanoparticles. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[6]  Detlef Lohse,et al.  Single bubble sonoluminescence , 2002 .

[7]  Suresh Das,et al.  Photoresponsive soft materials: Synthesis and photophysical studies of a stilbene‐based diblock copolymer , 2011 .

[8]  S R Cherry,et al.  Optical imaging of Cerenkov light generation from positron-emitting radiotracers , 2009, Physics in medicine and biology.

[9]  T. Kunitake,et al.  PHOTORESPONSIVE ARTIFICIAL MEMBRANE. REGULATION OF MEMBRANE PERMEABILITY OF LIPOSOMAL MEMBRANE BY PHOTOREVERSIBLE CIS‐TRANS ISOMERIZATION OF AZOBENZENES , 1981 .

[10]  Riccardo Calandrino,et al.  Cherenkov radiation imaging of beta emitters: in vitro and in vivo results , 2011 .

[11]  Ashok Gowda,et al.  MR thermometry‐based feedback control of laser interstitial thermal therapy at 980 nm , 2004, Lasers in surgery and medicine.

[12]  R. Bisby,et al.  Wavelength-programmed solute release from photosensitive liposomes. , 2000, Biochemical and biophysical research communications.

[13]  Wei Feng,et al.  Upconversion luminescent materials: advances and applications. , 2015, Chemical reviews.

[14]  N. Gagey-Eilstein,et al.  A blue-absorbing photolabile protecting group for in vivo chromatically orthogonal photoactivation. , 2013, ACS chemical biology.

[15]  B. Love,et al.  Coumarins in polymers: from light harvesting to photo-cross-linkable tissue scaffolds. , 2004, Chemical reviews.

[16]  Rajesh Subramaniam,et al.  Formulation of photocleavable liposomes and the mechanism of their content release. , 2006, Organic & biomolecular chemistry.

[17]  Tymish Y. Ohulchanskyy,et al.  Photodynamic therapy by in situ nonlinear photon conversion , 2014, Nature Photonics.

[18]  A. Eisenberg,et al.  Micellization of Ionic Block Copolymers , 1996 .

[19]  T. Taguchi,et al.  Photo-Switched Storage and Release of Guest Molecules in the Pore Void of Coumarin-Modified MCM-41 , 2003 .

[20]  Jan Grimm,et al.  Quantitative imaging of disease signatures through radioactive decay signal conversion , 2013, Nature Medicine.

[21]  F. J. G. M. Van Kuijk,et al.  Effects of ultraviolet light on the eye: role of protective glasses. , 1991 .

[22]  S. Regen,et al.  Polymerized phosphatidyl choline vesicles. Stabilized and controllable time-release carriers. , 1981, Biochemical and biophysical research communications.

[23]  Fang Liu,et al.  NIR light controlled photorelease of siRNA and its targeted intracellular delivery based on upconversion nanoparticles. , 2013, Nanoscale.

[24]  S. Webber,et al.  Onion-Type Micelles from Polystyrene-block-poly(2-vinylpyridine) and Poly(2-vinylpyridine)-block-poly(ethylene oxide) , 1999 .

[25]  Yue Zhao,et al.  Preparation of Azobenzene-Containing Amphiphilic Diblock Copolymers for Light-Responsive Micellar Aggregates , 2004 .

[26]  A. Puri.  Phototriggerable Liposomes: Current Research and Future Perspectives , 2013, Pharmaceutics.

[27]  S. Bonnet,et al.  Activation of a photodissociative ruthenium complex by triplet-triplet annihilation upconversion in liposomes. , 2014, Angewandte Chemie.

[28]  Michael R Hamblin,et al.  Role of Low‐Level Laser Therapy in Neurorehabilitation , 2010, PM & R : the journal of injury, function, and rehabilitation.

[29]  J. Ho,et al.  Photocontrolled targeted drug delivery: photocaged biologically active folic acid as a light-responsive tumor-targeting molecule. , 2012, Angewandte Chemie.

[30]  Wei Fan,et al.  Engineering the Upconversion Nanoparticle Excitation Wavelength: Cascade Sensitization of Tri‐doped Upconversion Colloidal Nanoparticles at 800 nm , 2013 .

[31]  Jeffrey I. Zink,et al.  Photo-Driven Expulsion of Molecules from Mesostructured Silica Nanoparticles , 2007 .

[32]  D. Kohane,et al.  NIR‐Triggered Drug Delivery by Collagen‐Mediated Second Harmonic Generation , 2015, Advanced healthcare materials.

[33]  S. Ganta,et al.  A review of stimuli-responsive nanocarriers for drug and gene delivery. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[34]  P. Hockberger,et al.  A History of Ultraviolet Photobiology for Humans, Animals and Microorganisms¶ , 2002, Photochemistry and photobiology.

[35]  Yue Zhao,et al.  Light-Responsive Block Copolymer Micelles , 2012 .

[36]  D. Kohane,et al.  Shedding light on nanomedicine. , 2012, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[37]  B. Smith,et al.  Synthesis and characterization of NVOC-DOPE, a caged photoactivatable derivative of dioleoylphosphatidylethanolamine. , 1999, Bioconjugate chemistry.

[38]  Wei Tao,et al.  Fabrication of Upconverting Hybrid Nanoparticles for Near-Infrared Light Triggered Drug Release , 2014 .

[39]  John-Christopher Boyer,et al.  Near-infrared light-triggered dissociation of block copolymer micelles using upconverting nanoparticles. , 2011, Journal of the American Chemical Society.

[40]  Yuichi Ohya,et al.  Photo-sensitive lipid membrane perturbation by a single chain lipid having terminal spiropyran group , 1998 .

[41]  W. Denk,et al.  Deep tissue two-photon microscopy , 2005, Nature Methods.

[42]  Samuel Achilefu,et al.  Breaking the Depth Dependency of Phototherapy with Cerenkov Radiation and Low Radiance Responsive Nanophotosensitizers , 2015, Nature nanotechnology.

[43]  W. Kirmse.  100 Years of the Wolff Rearrangement , 2002 .

[44]  Haiyang Li,et al.  Effect of surface microstructures on hydrophobicity and barrier property of anticorrosive coatings prepared by soft lithography , 2014 .

[45]  Yugui Yang,et al.  Researches on the Constitutive Models of Artificial Frozen Silt in Underground Engineering , 2014 .

[46]  C. Palivan,et al.  Photoresponsive polymersomes as smart, triggerable nanocarriers , 2011 .

[47]  R. Bisby,et al.  Photosensitive liposomes as ‘cages’ for laser‐triggered solute delivery: the effect of bilayer cholesterol on kinetics of solute release , 1999, FEBS letters.

[48]  W. Pitt,et al.  Ultrasonic drug delivery – a general review , 2004, Expert opinion on drug delivery.

[49]  Christopher Thrasivoulou,et al.  Second harmonic generation confocal microscopy of collagen type I from rat tendon cryosections. , 2006, Biophysical journal.

[50]  F Gonzalez-Lima,et al.  Low-level light therapy of the eye and brain. , 2011, Eye and brain.

[51]  Kristi S Anseth,et al.  Wavelength-controlled photocleavage for the orthogonal and sequential release of multiple proteins. , 2013, Angewandte Chemie.

[52]  Vincent M Rotello,et al.  Light-regulated release of DNA and its delivery to nuclei by means of photolabile gold nanoparticles. , 2006, Angewandte Chemie.

[53]  H. Muller,et al.  Ultraviolet light induced injury: Immunological and inflammatory effects , 2001, Immunology and cell biology.

[54]  D. Kohane,et al.  Efficient Triplet-Triplet Annihilation-Based Upconversion for Nanoparticle Phototargeting. , 2015, Nano letters.

[55]  Adah Almutairi,et al.  Low Power Upconverted Near‐IR Light for Efficient Polymeric Nanoparticle Degradation and Cargo Release , 2013, Advanced materials.

[56]  J. Warner,et al.  Core-bound polymeric micellar system based on photocrosslinking of thymine. , 2007, Chemical Communications.

[57]  Gert Storm,et al.  Constrained and UV-activatable cell-penetrating peptides for intracellular delivery of liposomes. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[58]  J. Boyer,et al.  Remote-control photorelease of caged compounds using near-infrared light and upconverting nanoparticles. , 2010, Angewandte Chemie.

[59]  A. Kutateladze,et al.  Dithiane-Based Photolabile Amphiphiles: Toward Photolabile Liposomes1,2 , 2003 .

[60]  Xianglong Hu,et al.  Photo-Triggered Release of Caged Camptothecin Prodrugs from Dually Responsive Shell Cross-Linked Micelles , 2013 .

[61]  Brian Seed,et al.  Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation , 2003, Nature Medicine.

[62]  Yong Ding,et al.  Self-Illuminating 64Cu-Doped CdSe/ZnS Nanocrystals for in Vivo Tumor Imaging , 2014, Journal of the American Chemical Society.

[63]  A. J. Tavares,et al.  Near-infrared-triggered anticancer drug release from upconverting nanoparticles. , 2014, ACS applied materials & interfaces.

[64]  Jeffrey I Zink,et al.  Light-activated nanoimpeller-controlled drug release in cancer cells. , 2008, Small.

[65]  Yongwoon Lee,et al.  Formation of Stable Nanocapsules from Polymerizable Phospholipids , 2003 .

[66]  Yue Zhao,et al.  Photocontrollable block copolymer micelles: what can we control? , 2009 .

[67]  M. Cima,et al.  A controlled-release microchip , 1999, Nature.

[68]  R. Langer,et al.  Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery , 2012, Journal of the American Chemical Society.

[69]  Brian P. Timko,et al.  Remotely Triggerable Drug Delivery Systems , 2010, Advanced materials.

[70]  Jennifer A. Prescher,et al.  Bioluminescence: a versatile technique for imaging cellular and molecular features. , 2014, MedChemComm.

[71]  R. Givens,et al.  Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy , 2012, Chemical reviews.

[72]  R. Weissleder.  A clearer vision for in vivo imaging , 2001, Nature Biotechnology.

[73]  P. Kratochvíl,et al.  Block and graft copolymer micelles in solution , 1976 .

[74]  K. Kataoka,et al.  Block copolymer micelles for drug delivery: design, characterization and biological significance. , 2001, Advanced drug delivery reviews.

[75]  Xing Ma,et al.  Functional mesoporous silica nanoparticles for photothermal-controlled drug delivery in vivo. , 2012, Angewandte Chemie.

[76]  Brian P. Timko,et al.  Photo-targeted nanoparticles. , 2010, Nano letters.

[77]  Robert Langer,et al.  Magnetically triggered nanocomposite membranes: a versatile platform for triggered drug release. , 2011, Nano letters.

[78]  Ariaya Hymete,et al.  A Recent Review on Chemiluminescence Reaction, Principle and Application on Pharmaceutical Analysis , 2013 .

[79]  G. Fleming,et al.  Synthetic micelle sensitive to IR light via a two-photon process. , 2005, Journal of the American Chemical Society.

[80]  Watt W Webb,et al.  Interpreting second-harmonic generation images of collagen I fibrils. , 2005, Biophysical journal.

[81]  Fuyou Li,et al.  Anticancer drug release from a mesoporous silica based nanophotocage regulated by either a one- or two-photon process. , 2010, Journal of the American Chemical Society.

[82]  R. Setlow,et al.  Evidence that pyrimidine dimers in DNA can give rise to tumors. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[83]  A. C. Mitchell,et al.  Light-induced fusion of liposomes with release of trapped marker dye is sensitised by photochromic phospholipid. , 1987, Biochimica et biophysica acta.

[84]  Adah Almutairi,et al.  UV and near-IR triggered release from polymeric nanoparticles. , 2010, Journal of the American Chemical Society.

[85]  Luc Tremblay,et al.  Flower micelles of poly(N-isopropylacrylamide) with azobenzene moieties regularly inserted into the main chain , 2011 .

[86]  Niveen M. Khashab,et al.  Light-operated mechanized nanoparticles. , 2009, Journal of the American Chemical Society.

[87]  Gonen Ashkenasy,et al.  Light induced drug delivery into cancer cells. , 2011, Biomaterials.

[88]  J. Zink,et al.  Two-photon-triggered drug delivery in cancer cells using nanoimpellers. , 2013, Angewandte Chemie.

[89]  Yue Zhao,et al.  How can azobenzene block copolymer vesicles be dissociated and reformed by light? , 2005, The journal of physical chemistry. B.

[90]  Venkata Krishna Kotharangannagari,et al.  Photoresponsive Reversible Aggregation and Dissolution of Rod–Coil Polypeptide Diblock Copolymers , 2011 .

[91]  Juan L. Vivero-Escoto,et al.  Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers. , 2008, Advanced drug delivery reviews.

[92]  Xiaogong Wang,et al.  Amphiphilic diblock copolymer with dithienylethene pendants: synthesis and photo-modulated self-assembly. , 2011, Macromolecular rapid communications.

[93]  Marek Romanowski,et al.  Light-Activated Content Release from Liposomes , 2012, Theranostics.

[94]  Juanjuan Peng,et al.  Near‐Infrared Photoregulated Drug Release in Living Tumor Tissue via Yolk‐Shell Upconversion Nanocages , 2014 .

[95]  Patrick Couvreur,et al.  Stimuli-responsive nanocarriers for drug delivery. , 2013, Nature materials.

[96]  Jianan Liu,et al.  NIR-triggered anticancer drug delivery by upconverting nanoparticles with integrated azobenzene-modified mesoporous silica. , 2013, Angewandte Chemie.

[97]  Josef Bille,et al.  Second harmonic generation imaging of collagen fibrils in cornea and sclera. , 2005, Optics express.

[98]  Wei Liu,et al.  UV- and NIR-responsive polymeric nanomedicines for on-demand drug delivery , 2013 .

[99]  B. Qi,et al.  Polymer Micelles Stabilization on Demand through Reversible Photo-Cross-Linking , 2007 .

[100]  Yue Zhao,et al.  Toward Photocontrolled Release Using Light-Dissociable Block Copolymer Micelles , 2006 .

[101]  V. Torchilin.  Recent advances with liposomes as pharmaceutical carriers , 2005, Nature Reviews Drug Discovery.

[102]  S. Yagai,et al.  Photocontrollable self-assembly. , 2005, Chemistry.

[103]  María Vallet-Regí,et al.  Mesoporous materials for drug delivery. , 2007, Angewandte Chemie.

[104]  Alina Y. Rwei,et al.  Photoresponsive nanoparticles for drug delivery. , 2015, Nano today.

[105]  W. Monroe,et al.  Silver nanoscale antisense drug delivery system for photoactivated gene silencing. , 2013, ACS nano.

[106]  J. Zink,et al.  Two-photon-triggered drug delivery via fluorescent nanovalves. , 2014, Small.

[107]  Krzysztof Matyjaszewski,et al.  Light-induced reversible formation of polymeric micelles. , 2007, Angewandte Chemie.

[108]  S. Yun,et al.  Optical fibers for high-resolution in vivo microendoscopic fluorescence imaging , 2013 .

[109]  Peng Wang,et al.  Photodegradable polyurethane self-assembled nanoparticles for photocontrollable release. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[110]  A. Kutateladze,et al.  Liposomes from novel photolabile phospholipids: light-induced unloading of small molecules as monitored by PFG NMR. , 2002, Journal of the American Chemical Society.

[111]  Yu-Lin Chou,et al.  Near-infrared light photocontrolled targeting, bioimaging, and chemotherapy with caged upconversion nanoparticles in vitro and in vivo. , 2013, ACS nano.