Many commonly used siRNAs risk off-target activity.
暂无分享,去创建一个
[1] A. Fire,et al. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[2] M. Amarzguioui,et al. Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor. , 2002, Nucleic acids research.
[3] Hongqiao Li,et al. Mammalian APH-1 Interacts with Presenilin and Nicastrin and Is Required for Intramembrane Proteolysis of Amyloid-β Precursor Protein and Notch* , 2002, The Journal of Biological Chemistry.
[4] Y. Miki,et al. Protein kinase Cδ is responsible for constitutive and DNA damage‐induced phosphorylation of Rad9 , 2003, The EMBO journal.
[5] C. Rossé,et al. The exocyst is a Ral effector complex , 2002, Nature Cell Biology.
[6] R. Bernards,et al. A System for Stable Expression of Short Interfering RNAs in Mammalian Cells , 2002, Science.
[7] Annick Harel-Bellan,et al. Synthetic small inhibiting RNAs: Efficient tools to inactivate oncogenic mutations and restore p53 pathways , 2002 .
[8] B. Cullen,et al. Sequence requirements for micro RNA processing and function in human cells. , 2003, RNA.
[9] M. Amarzguioui,et al. Tolerance for mutations and chemical modifications in a siRNA. , 2003, Nucleic acids research.
[10] Ali Ehsani,et al. Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells , 2002, Nature Biotechnology.
[11] B. Ramratnam,et al. Nucleotide sequence homology requirements of HIV-1-specific short hairpin RNA. , 2003, Nucleic acids research.
[12] Anindya Dutta,et al. Small RNAs with Imperfect Match to Endogenous mRNA Repress Translation , 2003, Journal of Biological Chemistry.
[13] Michael R. Green,et al. Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs). , 2004, RNA.
[14] J. Pouysségur,et al. HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia , 2003, The EMBO journal.
[15] T. Du,et al. Asymmetry in the Assembly of the RNAi Enzyme Complex , 2003, Cell.
[16] G. Courtois,et al. The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination , 2003, Nature.
[17] K Weber,et al. Identification of essential genes in cultured mammalian cells using small interfering RNAs. , 2001, Journal of cell science.
[18] Howard Y. Chang,et al. Genomewide view of gene silencing by small interfering RNAs , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[19] G. Hutvagner,et al. A microRNA in a Multiple-Turnover RNAi Enzyme Complex , 2002, Science.
[20] Ian Korf,et al. BLAST - an essential guide to the basic local alignment search tool , 2003 .
[21] J. Downward,et al. The Serine Protease Omi/HtrA2 Regulates Apoptosis by Binding XIAP through a Reaper-like Motif* , 2002, The Journal of Biological Chemistry.
[22] C. F. Bennett,et al. Efficient Reduction of Target RNAs by Small Interfering RNA and RNase H-dependent Antisense Agents , 2003, The Journal of Biological Chemistry.
[23] Ronald H. A. Plasterk,et al. RNA Silencing: The Genome's Immune System , 2002, Science.
[24] Stacy L DeRuiter,et al. RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[25] K. Sjögren,et al. Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2 , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[26] Jun Qin,et al. ATR and ATRIP: Partners in Checkpoint Signaling , 2001, Science.
[27] J. Puck,et al. Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency , 2002, Nature.
[28] S. Fesik,et al. Specificity of short interfering RNA determined through gene expression signatures , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[29] E. Nabel,et al. A growth factor‐dependent nuclear kinase phosphorylates p27Kip1 and regulates cell cycle progression , 2002, The EMBO journal.
[30] D. Baltimore,et al. Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5 , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[31] Phillip D Zamore,et al. Ancient Pathways Programmed by Small RNAs , 2002, Science.
[32] B. Li,et al. Expression profiling reveals off-target gene regulation by RNAi , 2003, Nature Biotechnology.
[33] E. Myers,et al. Basic local alignment search tool. , 1990, Journal of molecular biology.
[34] M. Amarzguioui,et al. Similar behaviour of single-strand and double-strand siRNAs suggests they act through a common RNAi pathway. , 2003, Nucleic acids research.
[35] Phillip A Sharp,et al. siRNAs can function as miRNAs , 2003 .
[36] V. Ambros,et al. Role of MicroRNAs in Plant and Animal Development , 2003, Science.
[37] Ximena Opitz-Araya,et al. Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization , 2002, Science.
[38] N. Shastri,et al. ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum , 2002, Nature.
[39] T. Tuschl,et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells , 2001, Nature.
[40] D. Tindall,et al. p300 mediates androgen-independent transactivation of the androgen receptor by interleukin 6. , 2002, Cancer research.
[41] Xiaoqi Liu,et al. Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[42] R. Lefkowitz,et al. Desensitization, internalization, and signaling functions of β-arrestins demonstrated by RNA interference , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[43] Olaf René Birkeland,et al. A recursive MISD architecture for pattern matching , 2004, IEEE Transactions on Very Large Scale Integration (VLSI) Systems.
[44] Martin Tabler,et al. Short 5′-phosphorylated double-stranded RNAs induce RNA interference in Drosophila , 2001, Current Biology.
[45] M S Waterman,et al. Identification of common molecular subsequences. , 1981, Journal of molecular biology.