Application of the dual sequence method to estimate the baroreflex sensitivity in patients with dilated cardiomyopathy

This study aims to estimate the spontaneous baroreflex sensitivity (BRS) with two different methods in patients with dilated cardiomyopathy (DCM). The new Dual Sequence Method (DSM) contains the analysis of spontaneous fluctuations of systolic blood pressure (SEP) and the corresponding beat-to-beat intervals (BBI) of heart rate (HR). Bradycardic as well as tachycardic fluctuations were considered for synchronized and a three beats shifted BBI-sequence. Whereas the established Z-coefficient method investigates the statistical dependence between SEP and HR values. The BRS and the number of fluctuations with a slope >5 msec/mmHg calculated by the DSM are significant lower (p<0.05) in DCM patients than in controls. Thus, the DSM leads in contrast to the Z-coefficient method to an improved precision in characterizing DCM patients.

[1]  P. Castiglioni,et al.  Investigating baroreflex control of circulation using signal processing techniques , 1997, IEEE Engineering in Medicine and Biology Magazine.

[2]  R. Hughson,et al.  Spontaneous cardiac baroreflex in humans. Comparison with drug-induced responses. , 1995, Hypertension.

[3]  R. Hughson,et al.  Spontaneous baroreflex by sequence and power spectral methods in humans. , 1993, Clinical physiology.

[4]  H. Krum,et al.  NON‐INVASIVE ASSESSMENT OF BAROREFLEX SENSITIVITY AND RELATION TO MEASURES OF HEART RATE VARIABILITY IN MAN , 1996, Clinical and experimental pharmacology & physiology.

[5]  J. Bigger,et al.  Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction , 1998, The Lancet.

[6]  Giuseppe Mancia,et al.  Spontaneous baroreflex sensitivity: From the cardiovascular laboratory to patient's bedside , 1997 .

[7]  C Cerutti,et al.  [Comparison of three methods for the estimation of spontaneous cardiac baroreflex sensitivity in normotensive and hypertensive subjects]. , 1995, Archives des maladies du coeur et des vaisseaux.

[8]  M. Thames,et al.  Abnormalities of baroreflex control in heart failure. , 1993, Journal of the American College of Cardiology.

[9]  K H Wesseling,et al.  Why use Finapres or Portapres rather than intra-arterial or intermittent non-invasive techniques of blood pressure measurement? , 1998, Journal of medical engineering & technology.

[10]  P. Schwartz,et al.  Baroreflex sensitivity, clinical correlates, and cardiovascular mortality among patients with a first myocardial infarction. A prospective study. , 1988, Circulation.