Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance

[1]  Hirotada Mori,et al.  A robust platform for chemical genomics in bacterial systems , 2016, Molecular biology of the cell.

[2]  Yi-Wei Tang,et al.  Emergence of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae. , 2016, The Lancet. Infectious diseases.

[3]  Jonathan M Stokes,et al.  Cold Stress Makes Escherichia coli Susceptible to Glycopeptide Antibiotics by Altering Outer Membrane Integrity. , 2016, Cell chemical biology.

[4]  E. Brown,et al.  Antibacterial drug discovery in the resistance era , 2016, Nature.

[5]  Jianzhong Shen,et al.  Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. , 2015, The Lancet. Infectious diseases.

[6]  Peter D. Karp,et al.  Pathway Tools version 19.0 update: software for pathway/genome informatics and systems biology , 2016, Briefings Bioinform..

[7]  R. Kaas,et al.  Detection of mcr-1 encoding plasmid-mediated colistin-resistant Escherichia coli isolates from human bloodstream infection and imported chicken meat, Denmark 2015. , 2015, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[8]  L. Hittle,et al.  Colistin-resistant Acinetobacter baumannii: beyond carbapenem resistance. , 2015, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[9]  E. Oldfield,et al.  Antibacterial drug leads: DNA and enzyme multitargeting. , 2015, Journal of medicinal chemistry.

[10]  Victor I Band,et al.  Mechanisms of Antimicrobial Peptide Resistance in Gram-Negative Bacteria , 2014, Antibiotics.

[11]  Erin E. Gill,et al.  Antibiotic Adjuvants: Diverse Strategies for Controlling Drug-Resistant Pathogens , 2014, Chemical biology & drug design.

[12]  J. Lakey,et al.  Effect of Divalent Cation Removal on the Structure of Gram-Negative Bacterial Outer Membrane Models , 2014, Langmuir : the ACS journal of surfaces and colloids.

[13]  Serge Morand,et al.  Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria , 2014, Front. Microbiol..

[14]  Joseph H. Davis,et al.  Discovery of a small molecule that inhibits bacterial ribosome biogenesis , 2014, eLife.

[15]  Chand S Mangat,et al.  Rank Ordering Plate Data Facilitates Data Visualization and Normalization in High-Throughput Screening , 2014, Journal of biomolecular screening.

[16]  Brittany D. Needham,et al.  Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis , 2013, Nature Reviews Microbiology.

[17]  S. Ray,et al.  Clinical Use of Colistin Induces Cross-Resistance to Host Antimicrobials in Acinetobacter baumannii , 2013, mBio.

[18]  Peter D. Karp,et al.  EcoCyc: fusing model organism databases with systems biology , 2012, Nucleic Acids Res..

[19]  Tsuyoshi Inoue,et al.  In situ potentiometric method to evaluate bacterial outer membrane-permeabilizing ability of drugs: example using antiprotozoal diamidines. , 2012, Journal of microbiological methods.

[20]  M. Kuehn,et al.  Offense and defense: microbial membrane vesicles play both ways. , 2012, Research in microbiology.

[21]  Mike Tyers,et al.  Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy. , 2011, Nature chemical biology.

[22]  Peter D. Karp,et al.  Pathway Tools version 13.0: integrated software for pathway/genome informatics and systems biology , 2015, Briefings Bioinform..

[23]  R. Nation,et al.  Colistin in the 21st century , 2009, Current opinion in infectious diseases.

[24]  A. Delcour,et al.  Outer membrane permeability and antibiotic resistance. , 2009, Biochimica et biophysica acta.

[25]  Yi Zhang,et al.  Pentamidine binds to tRNA through non-specific hydrophobic interactions and inhibits aminoacylation and translation , 2008, Nucleic acids research.

[26]  L. Dijkshoorn,et al.  An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii , 2007, Nature Reviews Microbiology.

[27]  H. Mori,et al.  Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection , 2006, Molecular systems biology.

[28]  D. Andersson,et al.  Effect of rpoB Mutations Conferring Rifampin Resistance on Fitness of Mycobacterium tuberculosis , 2004, Antimicrobial Agents and Chemotherapy.

[29]  H. Nikaido Molecular Basis of Bacterial Outer Membrane Permeability Revisited , 2003, Microbiology and Molecular Biology Reviews.

[30]  F. Odds,et al.  Synergy, antagonism, and what the chequerboard puts between them. , 2003, The Journal of antimicrobial chemotherapy.

[31]  G. Pier,et al.  Structural studies on the core and the O-polysaccharide repeating unit of Pseudomonas aeruginosa immunotype 1 lipopolysaccharide. , 2002, European journal of biochemistry.

[32]  S. David Towards a rational development of anti‐endotoxin agents: novel approaches to sequestration of bacterial endotoxins with small molecules , 2001, Journal of molecular recognition : JMR.

[33]  P D Karp,et al.  Pathway Databases: A Case Study in Computational Symbolic Theories , 2001, Science.

[34]  J. Cove,et al.  Mutation frequencies for resistance to fusidic acid and rifampicin in Staphylococcus aureus. , 2001, The Journal of antimicrobial chemotherapy.

[35]  Eduardo A. Groisman,et al.  The Pleiotropic Two-Component Regulatory System PhoP-PhoQ , 2001, Journal of bacteriology.

[36]  M. Leibowitz,et al.  Pentamidine Inhibition of Group I Intron Splicing in Candida albicans Correlates with Growth Inhibition , 2000, Antimicrobial Agents and Chemotherapy.

[37]  Ross Ihaka,et al.  Gentleman R: R: A language for data analysis and graphics , 1996 .

[38]  C. Chan,et al.  The safety of i.v. pentamidine administered in an ambulatory setting. , 1996, Chest.

[39]  H. Nikaido,et al.  Prevention of drug access to bacterial targets: permeability barriers and active efflux. , 1994, Science.

[40]  E. Rubinstein,et al.  Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice , 1994, Antimicrobial Agents and Chemotherapy.

[41]  M. Vaara,et al.  Agents that increase the permeability of the outer membrane. , 1992, Microbiological reviews.

[42]  M. Kron,et al.  Pentamidine: a review. , 1985, Reviews of infectious diseases.

[43]  M. Vaara,et al.  Polycations as outer membrane-disorganizing agents , 1983, Antimicrobial Agents and Chemotherapy.

[44]  H. Amos,et al.  EFFECT OF PENTAMIDINE ON THE GROWTH OF ESCHERICHIA COLI , 1957, Journal of bacteriology.

[45]  E. Greenspan,et al.  THE PHARMACOLOGY, MODE OF ACTION AND THERAPEUTIC POTENTIALITIES OF STILBAMIDINE, PENTAMIDINE, PROPAMIDINE AND OTHER AROMATIC DIAMIDINES—A REVIEW , 1948, Medicine.