IMPAIRMENT OF STREPTOMYCES AND MICROMONOSPORA DIFFERENTIATION BY DNA-METHYLASE INHIBITORS

Abstract The effect of several inhibitors of DNA methyltransferases has been tested on Streptomyces and Micromonospora cultures. Some of them (5-aza-2′-deoxycytidine, 5-azacytidine and L-ethionine), inhibited sporulation at concentrations that did not significantly affect growth.

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