论文信息 - Targeted drug delivery to magnetic implants for therapeutic applications

Targeted drug delivery to magnetic implants for therapeutic applications

A new method for locally targeted drug delivery is proposed that employs magnetic implants placed directly in the cardiovascular system to attract injected magnetic carriers. Theoretical simulations and experimental results support the assumption that using magnetic implants in combination with externally applied magnetic field will optimize the delivery of magnetic drug to selected sites within a subject.

[1] Remo Guidieri. Res , 1995, RES: Anthropology and Aesthetics.

[2] J. Koda,et al. Adsorption and desorption of chemotherapeutic drugs from a magnetically targeted carrier (MTC). , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[3] J. Richardson,et al. Phenotypic modulation of human articular chondrocytes by bistratene A. , 2002, European cells & materials.

[4] F. Friedlaender,et al. High gradient magnetic field particle capture on a single wire , 1975 .

[5] M. Takayasu,et al. A study of the mechanisms of particle buildup on single ferromagnetic wires and spheres , 1982 .

[6] C Alexiou,et al. Clinical applications of magnetic drug targeting. , 2001, The Journal of surgical research.

[7] Melba Phillips,et al. Classical Electricity and Magnetism , 1955 .

[8] R. Birss,et al. Particle motion near and capture on single spheres in HGMS , 1981 .

[9] M. Takayasu,et al. Observation of particle trajectories in an HGMS single-wire system , 1980 .

[10] Gary Friedman,et al. An approach to targeted drug delivery based on uniform magnetic fields , 2003 .

[11] R. Birss,et al. Particle buildup on single spheres in HGMS , 1981 .

[12] K Mosbach,et al. Preparation and application of magnetic polymers for targeting of drugs , 1979, FEBS letters.

[13] M. Saraste,et al. FEBS Lett , 2000 .

[14] M. Duch,et al. Electrodeposited Co-Ni alloys for MEMS , 2002 .