Lysosomal Association of Internalized

A B S T R A C T Quantitative electron microscopic autoradiographic studies in cultured human lymphocytes and isolated rat hepatocytes have demonstrated that labeled insulin initially localizes to the plasma membrane and is subsequently internalized to a limited region of the peripheral cytoplasm. When 0.5 nm '251-insulin is incubated with isolated rat hepatocytes, binding to the plasma membrane oc

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