Based on the virtual instrument technology, a structural health monitoring (SHM) system was developed for angle measurement with a platform of graphical programming language (the LabVIEW software) and embedded acquisition system (CompactRIO). This system can realize the real-time synchronous monitoring for the structure’s inclination, and the LabVIEW software was used to compile the program of epistatic machine, which can achieve the system program’s visualization interface aesthetics, and redevelop the program function expansion. Through the experimental verification, the developed system is verified to be practicable and reliable, and the experimental results show that the operating system based on the virtual instrument technology to monitor angles of the structure is stabile and simply operated as well as reconfigurable, which has a good application prospect.