CoCl2·6H2O or LaCl3·7H2O Catalyzed Biginelli Reaction. One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones

An efficient synthesis of 3,4-dihydropyrimidinones from aldehyde, β-keto ester and urea in ethanol using cobalt chloride hexahydrate or lanthanum chloride heptahydrate as a catalyst was described. Compared to the classical Biginelli reaction, this new method consistently has the advantage of good yields (56%-99%) as well as short reaction time (4–5 h).

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