MRI of the lung (1/3): methods

AbstractProton magnetic resonance imaging (MRI) has recently emerged as a clinical tool to image the lungs. This paper outlines the current technical aspects of MRI pulse sequences, radiofrequency (RF) coils and MRI system requirements needed for imaging the pulmonary parenchyma and vasculature. Lung MRI techniques are presented as a “technical toolkit”, from which MR protocols will be composed in the subsequent papers for comprehensive imaging of lung disease and function (parts 2 and 3). This paper is pitched at MR scientists, technicians and radiologists who are interested in understanding and establishing lung MRI methods. Images from a 1.5 T scanner are used for illustration of the sequences and methods that are highlighted. Main Messages • Outline of the hardware and pulse sequence requirements for proton lung MRI• Overview of pulse sequences for lung parenchyma, vascular and functional imaging with protons• Demonstration of the pulse-sequence building blocks for clinical lung MRI protocols

[1]  Jürgen Biederer,et al.  Magnetic resonance imaging and computed tomography of respiratory mechanics. , 2010, Journal of magnetic resonance imaging : JMRI.

[2]  H. Kauczor,et al.  In vivo Gd-DTPA concentration for MR lung perfusion measurements: Assessment with computed tomography in a porcine model , 2008, European Radiology.

[3]  P. Jakob,et al.  Assessment of human pulmonary function using oxygen‐enhanced T1 imaging in patients with cystic fibrosis , 2004, Magnetic resonance in medicine.

[4]  R Frayne,et al.  Time‐resolved contrast‐enhanced 3D MR angiography , 1996, Magnetic resonance in medicine.

[5]  M. Puderbach,et al.  MRI of the lung (3/3)—current applications and future perspectives , 2012, Insights into Imaging.

[6]  M. Puderbach,et al.  MRI of the lung (2/3). Why … when … how? , 2012, Insights into Imaging.

[7]  J Hennig,et al.  RARE imaging: A fast imaging method for clinical MR , 1986, Magnetic resonance in medicine.

[8]  S J Riederer,et al.  Performance of an elliptical centric view order for signal enhancement and motion artifact suppression in breath‐hold three‐dimensional gradient echo imaging , 1997, Magnetic resonance in medicine.

[9]  K. Scheffler,et al.  Are TrueFISP images T2/T1‐weighted? , 2002, Magnetic resonance in medicine.

[10]  Edwin J R van Beek,et al.  Rapid Lung Volumetry Using Ultrafast Dynamic Magnetic Resonance Imaging During Forced Vital Capacity Maneuver: Correlation With Spirometry , 2007, Investigative radiology.

[11]  Matthias Korn,et al.  Flow-compensated self-gating , 2008, Magnetic Resonance Materials in Physics, Biology and Medicine.

[12]  P. Jakob,et al.  Lung imaging under free‐breathing conditions , 2009, Magnetic resonance in medicine.

[13]  J. Wild,et al.  Lung morphology assessment with balanced steady-state free precession MR imaging compared with CT. , 2012, Radiology.

[14]  J M Pauly,et al.  Lung parenchyma: projection reconstruction MR imaging. , 1991, Radiology.

[15]  Michael Bock,et al.  Regional lung perfusion: assessment with partially parallel three-dimensional MR imaging. , 2004, Radiology.

[16]  P. Boesiger,et al.  SENSE: Sensitivity encoding for fast MRI , 1999, Magnetic resonance in medicine.

[17]  Robert R. Edelman,et al.  Noninvasive assessment of regional ventilation in the human lung using oxygen–enhanced magnetic resonance imaging , 1996, Nature Medicine.

[18]  P M Jakob,et al.  Resolution enhancement in lung 1H imaging using parallel imaging methods , 2003, Magnetic resonance in medicine.

[19]  Alan H Wilman,et al.  Navigator‐gated three‐dimensional MR angiography of the pulmonary arteries using steady‐state free precession , 2005, Journal of magnetic resonance imaging : JMRI.

[20]  Michael Deimling,et al.  Non‐contrast‐enhanced perfusion and ventilation assessment of the human lung by means of fourier decomposition in proton MRI , 2009, Magnetic resonance in medicine.

[21]  H. Kauczor,et al.  Oxygen-Enhanced Magnetic Resonance Imaging: Influence of Different Gas Delivery Methods on the T1-changes of the Lungs , 2008, Investigative radiology.

[22]  Markus Barth,et al.  T1 mapping of the entire lung parenchyma: Influence of the respiratory phase in healthy individuals , 2005, Journal of magnetic resonance imaging : JMRI.

[23]  P M Jakob,et al.  Rapid quantitative lung 1H T1 mapping , 2001, Journal of magnetic resonance imaging : JMRI.

[24]  Matthias F. Mueller,et al.  Parallel magnetic resonance imaging using the GRAPPA operator formalism , 2005, Magnetic resonance in medicine.

[25]  M. Reiser,et al.  MR lung imaging at 0.2 T with T1‐weighted true FISP: Native and oxygen‐enhanced , 2001, Journal of magnetic resonance imaging : JMRI.

[26]  Peter M Jakob,et al.  Lung MRI using an MR‐compatible active breathing control (MR‐ABC) , 2007, Magnetic resonance in medicine.

[27]  Thomas Henzler,et al.  Half‐fourier‐acquisition single‐shot turbo spin‐echo (HASTE) MRI of the lung at 3 Tesla using parallel imaging with 32‐receiver channel technology , 2009, Journal of magnetic resonance imaging : JMRI.

[28]  T. Vogl,et al.  Comparative evaluation of chest radiography, low-field MRI, the Shwachman-Kulczycki score and pulmonary function tests in patients with cystic fibrosis , 2008, European Radiology.

[29]  G C McKinnon,et al.  Breath-hold, contrast-enhanced, three-dimensional MR angiography. , 1996, Radiology.

[30]  C. Chefd'Hotel,et al.  Time Resolved Lung Ventilation Imaging by Fourier Decomposition , 2007 .

[31]  P. Jakob,et al.  Quantitative perfusion mapping of the human lung using 1H spin labeling , 2003, Journal of magnetic resonance imaging : JMRI.

[32]  M Puderbach,et al.  MR imaging of the chest: a practical approach at 1.5T. , 2007, European journal of radiology.