A Multiparameter Network Reveals Extensive Divergence between C. elegans bHLH Transcription Factors

[1]  Daniel E. Newburger,et al.  Diversity and Complexity in DNA Recognition by Transcription Factors , 2009, Science.

[2]  Daniel E. Newburger,et al.  High-resolution DNA-binding specificity analysis of yeast transcription factors. , 2009, Genome research.

[3]  M. Berger,et al.  Universal protein-binding microarrays for the comprehensive characterization of the DNA-binding specificities of transcription factors , 2009, Nature Protocols.

[4]  Martha L. Bulyk,et al.  UniPROBE: an online database of protein binding microarray data on protein–DNA interactions , 2008, Nucleic Acids Res..

[5]  Christian A. Grove,et al.  A Multiparameter Network Reveals Extensive Divergence Between C. elegans bHLH Transcription Factors: A Dissertation , 2009 .

[6]  V. Ambros,et al.  Genome-scale spatiotemporal analysis of Caenorhabditis elegans microRNA promoter activity. , 2008, Genome research.

[7]  A. Barabasi,et al.  High-Quality Binary Protein Interaction Map of the Yeast Interactome Network , 2008, Science.

[8]  V. Ambros,et al.  The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans. , 2008, Genes & development.

[9]  Ryan Doonan,et al.  HLH-3 is a C. elegans Achaete/Scute protein required for differentiation of the hermaphrodite-specific motor neurons , 2008, Mechanisms of Development.

[10]  Daniel E. Newburger,et al.  Variation in Homeodomain DNA Binding Revealed by High-Resolution Analysis of Sequence Preferences , 2008, Cell.

[11]  G. Stormo,et al.  Analysis of Homeodomain Specificities Allows the Family-wide Prediction of Preferred Recognition Sites , 2008, Cell.

[12]  J. Borlak,et al.  A loss-of-function mutation in the binding domain of HAND1 predicts hypoplasia of the human hearts. , 2008, Human molecular genetics.

[13]  David L Robertson,et al.  Choose your partners: dimerization in eukaryotic transcription factors. , 2008, Trends in biochemical sciences.

[14]  Christian A. Grove,et al.  Transcription factor functionality and transcription regulatory networks. , 2008, Molecular bioSystems.

[15]  M. Noyes,et al.  A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system , 2008, Nucleic acids research.

[16]  Fangxue Sherry He,et al.  Systematic identification of mammalian regulatory motifs' target genes and functions , 2008, Nature Methods.

[17]  Timothy Ravasi,et al.  A systems approach to delineate functions of paralogous transcription factors: Role of the Yap family in the DNA damage response , 2008, Proceedings of the National Academy of Sciences.

[18]  A. Fraser,et al.  A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans , 2008, Nature Genetics.

[19]  Antonella Longo,et al.  Crystal structure of E47-NeuroD1/beta2 bHLH domain-DNA complex: heterodimer selectivity and DNA recognition. , 2008, Biochemistry.

[20]  Sarah A. Teichmann,et al.  DBD––taxonomically broad transcription factor predictions: new content and functionality , 2007, Nucleic Acids Res..

[21]  K. Oegema,et al.  Expression and imaging of fluorescent proteins in the C. elegans gonad and early embryo. , 2008, Methods in cell biology.

[22]  Eric H Davidson,et al.  A Gene Regulatory Network Subcircuit Drives a Dynamic Pattern of Gene Expression , 2007, Science.

[23]  Christopher L. Pickett,et al.  A C. elegans Myc-like network cooperates with semaphorin and Wnt signaling pathways to control cell migration. , 2007, Developmental biology.

[24]  Koichi Saito,et al.  Characterization of Drosophila and Caenorhabditis elegans NXF-like-factors, putative homologs of mammalian NXF. , 2007, Gene.

[25]  Michael L. Creech,et al.  Integration of biological networks and gene expression data using Cytoscape , 2007, Nature Protocols.

[26]  Erik van Nimwegen,et al.  Finding regulatory elements and regulatory motifs: a general probabilistic framework , 2007, BMC Bioinformatics.

[27]  Steven J. M. Jones,et al.  High-Throughput In Vivo Analysis of Gene Expression in Caenorhabditis elegans , 2007, PLoS biology.

[28]  K. Tamai,et al.  bHLH transcription factors regulate organ morphogenesis via activation of an ADAMTS protease in C. elegans. , 2007, Developmental biology.

[29]  Peter C. Hollenhorst,et al.  Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family. , 2007, Genes & development.

[30]  Albert-László Barabási,et al.  Transcription factor modularity in a gene-centered C. elegans core neuronal protein-DNA interaction network. , 2007, Genome research.

[31]  Steven J. M. Jones,et al.  The molecular signature and cis-regulatory architecture of a C. elegans gustatory neuron. , 2007, Genes & development.

[32]  Lynn Doucette-Stamm,et al.  Matrix and Steiner-triple-system smart pooling assays for high-performance transcription regulatory network mapping , 2007, Nature Methods.

[33]  Anthony A. Philippakis,et al.  Design of Compact, Universal DNA Microarrays for Protein Binding Microarray Experiments , 2007, RECOMB.

[34]  G. Blandino,et al.  Mutant p53: an oncogenic transcription factor , 2007, Oncogene.

[35]  Christian A. Grove,et al.  Insight into transcription factor gene duplication from Caenorhabditis elegans Promoterome-driven expression patterns , 2007, BMC Genomics.

[36]  S. Quake,et al.  A Systems Approach to Measuring the Binding Energy Landscapes of Transcription Factors , 2007, Science.

[37]  Morgane Thomas-Chollier,et al.  Origin and diversification of the basic helix-loop-helix gene family in metazoans: insights from comparative genomics , 2007, BMC Evolutionary Biology.

[38]  L. Jacotot,et al.  EDGEdb: a transcription factor-DNA Interaction database for the analysis of C. elegans differential gene expression , 2007, BMC Genomics.

[39]  Albertha J. M. Walhout,et al.  Unraveling transcription regulatory networks by protein-DNA and protein-protein interaction mapping. , 2006, Genome research.

[40]  J. Schwarzbauer,et al.  A systematic RNA interference screen reveals a cell migration gene network in C. elegans , 2006, Journal of Cell Science.

[41]  A. Philippakis,et al.  Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities , 2006, Nature Biotechnology.

[42]  Ling V. Sun,et al.  Hotspots of transcription factor colocalization in the genome of Drosophila melanogaster , 2006, Proceedings of the National Academy of Sciences.

[43]  M. Y. Kim,et al.  Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor. , 2006, Molecular endocrinology.

[44]  Christian A. Grove,et al.  A Gene-Centered C. elegans Protein-DNA Interaction Network , 2006, Cell.

[45]  Michael P. Eichenlaub,et al.  A temporal map of transcription factor activity: mef2 directly regulates target genes at all stages of muscle development. , 2006, Developmental cell.

[46]  C. Glass,et al.  Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. , 2006, Genes & development.

[47]  Osamu Nakajima,et al.  In vivo oxygen imaging using green fluorescent protein. , 2006, American journal of physiology. Cell physiology.

[48]  Rafael A. Irizarry,et al.  Comparison of Affymetrix GeneChip expression measures , 2006, Bioinform..

[49]  D. Mangelsdorf,et al.  Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans , 2006, Cell.

[50]  Mark Gerstein,et al.  Target hub proteins serve as master regulators of development in yeast. , 2006, Genes & development.

[51]  Michael R. Green,et al.  Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation , 2006, Nature Genetics.

[52]  Sarah A. Teichmann,et al.  DBD: a transcription factor prediction database , 2005, Nucleic Acids Res..

[53]  Mike Tyers,et al.  BioGRID: a general repository for interaction datasets , 2005, Nucleic Acids Res..

[54]  H. Sone,et al.  TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes , 2006, Nature Medicine.

[55]  S. Wolfe,et al.  Identifying DNA sequences recognized by a transcription factor using a bacterial one-hybrid system , 2006, Nature Protocols.

[56]  Christian A. Grove,et al.  A compendium of Caenorhabditis elegans regulatory transcription factors: a resource for mapping transcription regulatory networks , 2005, Genome Biology.

[57]  Megan F. Cole,et al.  Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells , 2005, Cell.

[58]  Marc Vidal,et al.  Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis , 2005, Nature.

[59]  M. Brodsky,et al.  A bacterial one-hybrid system for determining the DNA-binding specificity of transcription factors , 2005, Nature Biotechnology.

[60]  Michael G. Rosenfeld,et al.  Controlling nuclear receptors: the circular logic of cofactor cycles , 2005, Nature Reviews Molecular Cell Biology.

[61]  Gary D. Stormo,et al.  enoLOGOS: a versatile web tool for energy normalized sequence logos , 2005, Nucleic Acids Res..

[62]  J. Priess,et al.  The REF-1 family of bHLH transcription factors pattern C. elegans embryos through Notch-dependent and Notch-independent pathways. , 2005, Developmental cell.

[63]  Chaochun Wei,et al.  Closing in on the C. elegans ORFeome by cloning TWINSCAN predictions. , 2005, Genome research.

[64]  A. Fire,et al.  Cyclin D involvement demarcates a late transition in C. elegans embryogenesis. , 2005, Developmental biology.

[65]  V. Centonze,et al.  Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities , 2005, Nature Genetics.

[66]  R. Roeder,et al.  Transcriptional regulation and the role of diverse coactivators in animal cells , 2005, FEBS letters.

[67]  K. Yamamoto,et al.  Nuclear Hormone Receptor NHR-49 Controls Fat Consumption and Fatty Acid Composition in C. elegans , 2005, PLoS biology.

[68]  S. Okano,et al.  Genetic oxygen sensor: GFP as an indicator of intracellular oxygenation. , 2005, Advances in experimental medicine and biology.

[69]  R. Tsien,et al.  Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein , 2004, Nature Biotechnology.

[70]  R. Young,et al.  Rapid analysis of the DNA-binding specificities of transcription factors with DNA microarrays , 2004, Nature Genetics.

[71]  David N. Messina,et al.  An ORFeome-based analysis of human transcription factor genes and the construction of a microarray to interrogate their expression. , 2004, Genome research.

[72]  J. Hartley,et al.  Concerted assembly and cloning of multiple DNA segments using in vitro site-specific recombination: functional analysis of multi-segment expression clones. , 2004, Genome research.

[73]  David E Hill,et al.  A first version of the Caenorhabditis elegans Promoterome. , 2004, Genome research.

[74]  M. Vidal,et al.  A gateway-compatible yeast one-hybrid system. , 2004, Genome research.

[75]  Terry Gaasterland,et al.  Alternative splicing of mouse transcription factors affects their DNA-binding domain architecture and is tissue specific , 2004, Genome Biology.

[76]  M. Gerstein,et al.  Genomic analysis of regulatory network dynamics reveals large topological changes , 2004, Nature.

[77]  Nicola J. Rinaldi,et al.  Transcriptional regulatory code of a eukaryotic genome , 2004, Nature.

[78]  Cristian I. Castillo-Davis,et al.  cis-Regulatory and protein evolution in orthologous and duplicate genes. , 2004, Genome research.

[79]  Hongtao Qin,et al.  The Caenorhabditis elegans aryl hydrocarbon receptor, AHR-1, regulates neuronal development. , 2004, Developmental biology.

[80]  M. Gerstein,et al.  Structure and evolution of transcriptional regulatory networks. , 2004, Current opinion in structural biology.

[81]  Oliver Hobert,et al.  A Conserved Postsynaptic Transmembrane Protein Affecting Neuromuscular Signaling in Caenorhabditis elegans , 2004, The Journal of Neuroscience.

[82]  Yishi Jin,et al.  The AHR-1 aryl hydrocarbon receptor and its co-factor the AHA-1 aryl hydrocarbon receptor nuclear translocator specify GABAergic neuron cell fate in C. elegans , 2004, Development.

[83]  Benjamin M. Bolstad,et al.  affy - analysis of Affymetrix GeneChip data at the probe level , 2004, Bioinform..

[84]  Gordon K Smyth,et al.  Statistical Applications in Genetics and Molecular Biology Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments , 2011 .

[85]  Bert W O'Malley,et al.  Coregulator function: a key to understanding tissue specificity of selective receptor modulators. , 2004, Endocrine reviews.

[86]  J. Castle,et al.  Genome-Wide Survey of Human Alternative Pre-mRNA Splicing with Exon Junction Microarrays , 2003, Science.

[87]  M. Denison,et al.  Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. , 2003, Annual review of pharmacology and toxicology.

[88]  P. Shannon,et al.  Cytoscape: a software environment for integrated models of biomolecular interaction networks. , 2003, Genome research.

[89]  Andrew G Fraser,et al.  Genome-Wide RNAi of C. elegans Using the Hypersensitive rrf-3 Strain Reveals Novel Gene Functions , 2003, PLoS biology.

[90]  J. Kimble,et al.  The C. elegans Hand gene controls embryogenesis and early gonadogenesis , 2003, Development.

[91]  A. Keating,et al.  Comprehensive Identification of Human bZIP Interactions with Coiled-Coil Arrays , 2003, Science.

[92]  J. Hudson,et al.  C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression , 2003, Nature Genetics.

[93]  A I Saeed,et al.  TM4: a free, open-source system for microarray data management and analysis. , 2003, BioTechniques.

[94]  Gary Ruvkun,et al.  Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes , 2003, Nature.

[95]  May D. Wang,et al.  GoMiner: a resource for biological interpretation of genomic and proteomic data , 2003, Genome Biology.

[96]  A. Firulli,et al.  The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene. , 2002, Journal of molecular and cellular cardiology.

[97]  S. Lewis,et al.  The generic genome browser: a building block for a model organism system database. , 2002, Genome research.

[98]  P. Bourgine,et al.  Topological and causal structure of the yeast transcriptional regulatory network , 2002, Nature Genetics.

[99]  S. Shen-Orr,et al.  Network motifs in the transcriptional regulation network of Escherichia coli , 2002, Nature Genetics.

[100]  Yanhui Hu,et al.  Proteome-scale purification of human proteins from bacteria , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[101]  L. Hood,et al.  A Genomic Regulatory Network for Development , 2002, Science.

[102]  S. Shen-Orr,et al.  Networks Network Motifs : Simple Building Blocks of Complex , 2002 .

[103]  Valérie Ledent,et al.  Phylogenetic analysis of the human basic helix-loop-helix proteins , 2002, Genome Biology.

[104]  Robert L Davis,et al.  Vertebrate hairy and Enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning , 2001, Oncogene.

[105]  I. Greenwald,et al.  Genetic analysis of endocytosis in Caenorhabditis elegans: coelomocyte uptake defective mutants. , 2001, Genetics.

[106]  D. Hirsh,et al.  RME-8, a conserved J-domain protein, is required for endocytosis in Caenorhabditis elegans. , 2001, Molecular biology of the cell.

[107]  M. Vidal,et al.  High-throughput yeast two-hybrid assays for large-scale protein interaction mapping. , 2001, Methods.

[108]  H. Jiang,et al.  The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[109]  Ian Korf,et al.  Integrating genomic homology into gene structure prediction , 2001, ISMB.

[110]  E. Nagoshi,et al.  Dimerization of Sterol Regulatory Element-Binding Protein 2 via the Helix-Loop-Helix-Leucine Zipper Domain Is a Prerequisite for Its Nuclear Localization Mediated by Importin β , 2001, Molecular and Cellular Biology.

[111]  Douglas S. Portman,et al.  The basic helix-loop-helix transcription factors LIN-32 and HLH-2 function together in multiple steps of a C. elegans neuronal sublineage. , 2000, Development.

[112]  R. Ranganathan,et al.  The structural basis for red fluorescence in the tetrameric GFP homolog DsRed , 2000, Nature Structural Biology.

[113]  R Y Tsien,et al.  Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[114]  R. Tjian,et al.  Orchestrated response: a symphony of transcription factors for gene control. , 2000, Genes & development.

[115]  S. Hallam,et al.  The C. elegans NeuroD homolog cnd-1 functions in multiple aspects of motor neuron fate specification. , 2000, Development.

[116]  M. Wegner,et al.  The glial transcription factor Sox10 binds to DNA both as monomer and dimer with different functional consequences. , 2000, Nucleic acids research.

[117]  M. Ashburner,et al.  Gene Ontology: tool for the unification of biology , 2000, Nature Genetics.

[118]  S. Henikoff,et al.  Identification of in vivo DNA targets of chromatin proteins using tethered Dam methyltransferase , 2000, Nature Biotechnology.

[119]  C. Murre,et al.  Helix-Loop-Helix Proteins: Regulators of Transcription in Eucaryotic Organisms , 2000, Molecular and Cellular Biology.

[120]  M. Vidal,et al.  Protein interaction mapping in C. elegans using proteins involved in vulval development. , 2000, Science.

[121]  M. Vidal,et al.  GATEWAY recombinational cloning: application to the cloning of large numbers of open reading frames or ORFeomes. , 2000, Methods in enzymology.

[122]  R. Eisenman,et al.  The Myc/Max/Mad network and the transcriptional control of cell behavior. , 2000, Annual review of cell and developmental biology.

[123]  M. Vidal,et al.  A genetic strategy to eliminate self-activator baits prior to high-throughput yeast two-hybrid screens. , 1999, Genome research.

[124]  L. Zon,et al.  Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding. , 1999, Development.

[125]  Lisa Garrett,et al.  The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia , 1999, Nature Genetics.

[126]  V. Giguère,et al.  Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1. , 1999, Molecular cell.

[127]  I. Shimomura,et al.  Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis. , 1999, Current opinion in lipidology.

[128]  C. Wolberger,et al.  Multiprotein-DNA complexes in transcriptional regulation. , 1999, Annual review of biophysics and biomolecular structure.

[129]  M. Denison,et al.  The Ah Receptor: A Regulator of the Biochemical and Toxicological Actions of Structurally Diverse Chemicals , 1998, Bulletin of environmental contamination and toxicology.

[130]  M. Cole,et al.  The C. elegans MDL-1 and MXL-1 proteins can functionally substitute for vertebrate MAD and MAX , 1998, Oncogene.

[131]  A. Fire,et al.  Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning. , 1998, Genes & development.

[132]  S K Burley,et al.  Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution. , 1998, Structure.

[133]  A. J. Walhout,et al.  Sequences flanking the E-box contribute to cooperative binding by c-Myc/Max heterodimers to adjacent binding sites. , 1998, Biochimica et biophysica acta.

[134]  W B Wood,et al.  Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hydrocarbon receptor nuclear translocator. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[135]  S. Crews,et al.  Control of Cell Lineage-specific Development and Transcription by Bhlh–pas Proteins , 2022 .

[136]  J. Thompson,et al.  The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. , 1997, Nucleic acids research.

[137]  K. Struhl,et al.  Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions , 1997, Molecular and cellular biology.

[138]  G. Ruvkun,et al.  The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans , 1997, Nature.

[139]  A. Fire,et al.  A C. elegans E/Daughterless bHLH protein marks neuronal but not striated muscle development. , 1997, Development.

[140]  W. Atchley,et al.  A natural classification of the basic helix-loop-helix class of transcription factors. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[141]  N. Perrimon,et al.  The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz , 1997, Nature.

[142]  E. Green,et al.  Mutations in TWIST, a basic helix–loop–helix transcription factor, in Saethre-Chotzen syndrome , 1997, Nature Genetics.

[143]  Roderic D. M. Page,et al.  TreeView: an application to display phylogenetic trees on personal computers , 1996, Comput. Appl. Biosci..

[144]  James A. Vaught,et al.  microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family. , 1994, Genes & development.

[145]  M. Caudy,et al.  Hairy function as a DNA-binding helix-loop-helix repressor of Drosophila sensory organ formation. , 1994, Genes & development.

[146]  J. Posakony,et al.  Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete. , 1994, Genes & development.

[147]  J. Thompson,et al.  CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. , 1994, Nucleic acids research.

[148]  A. Fire,et al.  The Caenorhabditis elegans MYOD homologue HLH-1 is essential for proper muscle function and complete morphogenesis. , 1994, Development.

[149]  Carl O. Pabo,et al.  Crystal structure of MyoD bHLH domain-DNA complex: Perspectives on DNA recognition and implications for transcriptional activation , 1994, Cell.

[150]  S. Harrison,et al.  Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer. , 1994, Genes & development.

[151]  A. Ferré-D’Amaré,et al.  Structure and function of the b/HLH/Z domain of USF. , 1994, The EMBO journal.

[152]  M. Yaniv,et al.  More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing. , 1993, The EMBO journal.

[153]  Stephen K. Burley,et al.  Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain , 1993, Nature.

[154]  R. Shigemoto,et al.  Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. , 1992, Genes & development.

[155]  C. Goding,et al.  Single amino acid substitutions alter helix‐loop‐helix protein specificity for bases flanking the core CANNTG motif. , 1992, The EMBO journal.

[156]  R. Kageyama,et al.  Molecular characterization of a rat negative regulator with a basic helix-loop-helix structure predominantly expressed in the developing nervous system. , 1992, The Journal of biological chemistry.

[157]  E. Knust,et al.  Enhancer of splitD, a dominant mutation of Drosophila, and its use in the study of functional domains of a helix-loop-helix protein. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[158]  S. Fields,et al.  The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[159]  S. McKnight,et al.  Diversity and specificity in transcriptional regulation: the benefits of heterotypic dimerization. , 1991, Trends in biochemical sciences.

[160]  H. Weintraub,et al.  Sequence-specific DNA binding by the c-Myc protein. , 1990, Science.

[161]  T. D. Schneider,et al.  Sequence logos: a new way to display consensus sequences. , 1990, Nucleic acids research.

[162]  J. Szostak,et al.  In vitro selection of RNA molecules that bind specific ligands , 1990, Nature.

[163]  L. Gold,et al.  Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. , 1990, Science.

[164]  A. Berk Regulation of eukaryotic transcription factors by post-translational modification. , 1989, Biochimica et biophysica acta.

[165]  S. Fields,et al.  A novel genetic system to detect protein–protein interactions , 1989, Nature.

[166]  W. Gehring,et al.  Redesigning the body plan of Drosophilaby ectopic expression of the homoeotic gene Antennapedia , 1987, Nature.

[167]  S. Brenner,et al.  The structure of the nervous system of the nematode Caenorhabditis elegans. , 1986, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[168]  W. Gehring,et al.  Homeotic transformation of thorax into head: Developmental analysis of a new Antennapedia allele in Drosophila melanogaster , 1985 .

[169]  M. Klass,et al.  Development of the reproductive system of Caenorhabditis elegans. , 1976, Developmental biology.