Sensitivity of p53-Deficient Cells to Oxaliplatin and Thio-TEPA (N, N′, N″ Triethylenethiophosphoramide)

[1]  Gang Li,et al.  The tumor suppressor candidate p33(ING1) mediates repair of UV-damaged DNA. , 2001, Cancer research.

[2]  T. Lindahl,et al.  The expression of vascular endothelial growth factor correlates with mutant p53 and poor prognosis in human breast cancer. , 2001, Cancer research.

[3]  Samuel H. Wilson,et al.  A role for p53 in base excision repair , 2001, The EMBO journal.

[4]  V. Rotter,et al.  p53 modulates base excision repair activity in a cell cycle-specific manner after genotoxic stress. , 2001, Cancer research.

[5]  B. Dörken,et al.  Impaired BAX protein expression in breast cancer: Mutational analysis of the BAX and the p53 gene , 2000, International journal of cancer.

[6]  J. Bergh,et al.  Predictive value of p53, mdm-2, p21, and mib-1 for chemotherapy response in advanced breast cancer. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[7]  P. Hanawalt,et al.  p53-Mediated DNA Repair Responses to UV Radiation: Studies of Mouse Cells Lacking p53, p21, and/orgadd45 Genes , 2000, Molecular and Cellular Biology.

[8]  R. Vossen,et al.  Complete sequencing of TP53 predicts poor response to systemic therapy of advanced breast cancer. , 2000, Cancer research.

[9]  A. Ramaioli,et al.  P53 determination alongside classical prognostic factors in node-negative breast cancer: an evaluation at more than 10-year follow-up. , 2000, Annals of oncology : official journal of the European Society for Medical Oncology.

[10]  Q. Zhu,et al.  p53-degradation by HPV-16 E6 preferentially affects the removal of cyclobutane pyrimidine dimers from non-transcribed strand and sensitizes mammary epithelial cells to UV-irradiation. , 2000, Mutation research.

[11]  J. Bertino,et al.  Modulation of cisplatinum cytotoxicity by p53: effect of p53-mediated apoptosis and DNA repair. , 1999, Molecular pharmacology.

[12]  V. Rotter,et al.  Epithelial cells of different organs exhibit distinct patterns of p53-dependent and p53-independent apoptosis following DNA insult. , 1999, Experimental cell research.

[13]  N. Farrell,et al.  A novel charged trinuclear platinum complex effective against cisplatin-resistant tumours: hypersensitivity of p53-mutant human tumour xenografts , 1999, British Journal of Cancer.

[14]  V. Rotter,et al.  Accentuated apoptosis in normally developing p53 knockout mouse embryos following genotoxic stress , 1999, Oncogene.

[15]  B. Wouters,et al.  Apoptosis, p53, and tumor cell sensitivity to anticancer agents. , 1999, Cancer research.

[16]  T. Myers,et al.  Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin , 1999, Molecular and Cellular Biology.

[17]  P. Hanawalt,et al.  Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[18]  D. Grant,et al.  Nucleotide excision repair of melphalan monoadducts. , 1998, Cancer research.

[19]  A. Jomard,et al.  Pharmacology of adapalene , 1998, The British journal of dermatology.

[20]  Kumar,et al.  Protein kinase C isoform levels in normal and sodium dodecyl sulphate‐irritated mouse skin , 1998, The British journal of dermatology.

[21]  G. Li,et al.  p53‐Dependent DNA repair and apoptosis respond differently to high‐ and low‐dose ultraviolet radiation , 1998, The British journal of dermatology.

[22]  T. Jacks,et al.  p53-Dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[23]  W. Kaufmann,et al.  p53-dependent signaling sustains DNA replication and enhances clonogenic survival in 254 nm ultraviolet-irradiated human fibroblasts. , 1998, Cancer research.

[24]  P. Hanawalt,et al.  Human fibroblasts expressing the human papillomavirus E6 gene are deficient in global genomic nucleotide excision repair and sensitive to ultraviolet irradiation. , 1998, Cancer research.

[25]  P. Hanawalt,et al.  Expression of Wild-type p53 Is Required for Efficient Global Genomic Nucleotide Excision Repair in UV-irradiated Human Fibroblasts* , 1997, The Journal of Biological Chemistry.

[26]  A. Levine.  p53, the Cellular Gatekeeper for Growth and Division , 1997, Cell.

[27]  F. Oesch,et al.  Induction of DNA crosslinks and DNA strand lesions by cyclophosphamide after activation by cytochrome P450 2B1. , 1997, Mutation research.

[28]  J. Brown,et al.  NCI's anticancer drug screening program may not be selecting for clinically active compounds. , 1997, Oncology research.

[29]  K. Paull,et al.  Oxaliplatin, tetraplatin, cisplatin, and carboplatin: spectrum of activity in drug-resistant cell lines and in the cell lines of the National Cancer Institute's Anticancer Drug Screen panel. , 1996, Biochemical pharmacology.

[30]  H. Nguyen,et al.  Drug-resistant breast cancer cells frequently retain expression of a functional wild-type p53 protein. , 1996, Carcinogenesis.

[31]  G. Demers,et al.  Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents. , 1996, Cancer research.

[32]  D. Murray,et al.  Nucleotide excision repair genes as determinants of cellular sensitivity to cyclophosphamide analogs , 1996, Cancer Chemotherapy and Pharmacology.

[33]  S. Bates,et al.  Normal p53 status and function despite the development of drug resistance in human breast cancer cells. , 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[34]  P. Glazer,et al.  p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells. , 1995, Cancer research.

[35]  P. Hanawalt,et al.  Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[36]  R. Schlegel,et al.  The human papilloma virus 16E6 gene sensitizes human mammary epithelial cells to apoptosis induced by DNA damage. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[37]  K. Kohn,et al.  Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline. , 1995, Cancer research.

[38]  P. O'Connor,et al.  Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage. , 1995, Oncogene.

[39]  K. Kohn,et al.  p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents. , 1994, Cancer research.

[40]  D. Housman,et al.  p53-dependent apoptosis modulates the cytotoxicity of anticancer agents , 1993, Cell.

[41]  T. Mikkelsen,et al.  Clonal expansion of p53 mutant cells is associated with brain tumour progression , 1992, Nature.

[42]  M. Egorin,et al.  Interaction of N,N',N''-triethylenethiophosphoramide and N,N',N''-triethylenephosphoramide with cellular DNA. , 1991, Cancer research.