How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity

[1]  Youngjo Lee,et al.  Frailty modeling for clustered competing risks data with missing cause of failure , 2017, Statistical methods in medical research.

[2]  C. Chakraborty.  Aging and health - A systems biology perspective , 2015, The Indian Journal of Medical Research.

[3]  Francesco Cucca,et al.  Methods for Association Analysis and Meta‐Analysis of Rare Variants in Families , 2015, Genetic epidemiology.

[4]  Thomas B. L. Kirkwood,et al.  Deciphering death: a commentary on Gompertz (1825) ‘On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies’ , 2015, Philosophical Transactions of the Royal Society B: Biological Sciences.

[5]  B. Morris,et al.  Genetic analysis of TOR complex gene variation with human longevity: a nested case-control study of American men of Japanese ancestry. , 2015, The journals of gerontology. Series A, Biological sciences and medical sciences.

[6]  Mouming Zhao,et al.  A Correlation Between Diet and Longevity Characterization by Means of Element Profiles in Healthy People over 80 Years from a Chinese Longevous Region , 2015, Biological Trace Element Research.

[7]  James J. Anderson,et al.  The Strehler–Mildvan correlation from the perspective of a two-process vitality model , 2015, Population studies.

[8]  Odd O Aalen,et al.  Understanding variation in disease risk: the elusive concept of frailty , 2014, International journal of epidemiology.

[9]  R. Gomulkiewicz,et al.  The Genetics of Phenotypic Plasticity , 2015 .

[10]  Toshiko Tanaka,et al.  GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. , 2015, The journals of gerontology. Series A, Biological sciences and medical sciences.

[11]  A. Yashin,et al.  Genetic Structures of Population Cohorts Change with Increasing Age: Implications for Genetic Analyses of Human aging and Life Span. , 2017, Annals of gerontology and geriatric research.

[12]  F. Hu,et al.  Mediterranean diet and telomere length in Nurses’ Health Study: population based cohort study , 2014, BMJ : British Medical Journal.

[13]  Y. Sapkota.  Germline DNA Variations in Breast Cancer Predisposition and Prognosis: A Systematic Review of the Literature , 2014, Cytogenetic and Genome Research.

[14]  J. P. D. Magalhães.  Why genes extending lifespan in model organisms have not been consistently associated with human longevity and what it means to translation research. , 2014 .

[15]  T. Flatt.  Plasticity of lifespan: a reaction norm perspective , 2014, Proceedings of the Nutrition Society.

[16]  João Pedro de Magalhães,et al.  Why genes extending lifespan in model organisms have not been consistently associated with human longevity and what it means to translation research , 2014, Cell cycle.

[17]  G. Abecasis,et al.  Rare-variant association analysis: study designs and statistical tests. , 2014, American journal of human genetics.

[18]  E. Epel,et al.  Stress biology and aging mechanisms: toward understanding the deep connection between adaptation to stress and longevity. , 2014, The journals of gerontology. Series A, Biological sciences and medical sciences.

[19]  Jutta Gampe,et al.  Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age , 2014, Human molecular genetics.

[20]  T. Benton,et al.  Stressful environments can indirectly select for increased longevity , 2014, Ecology and evolution.

[21]  S. Carding,et al.  Mechanisms of Ageing and Development , 2014 .

[22]  M. Goddard,et al.  A Multi-Trait, Meta-analysis for Detecting Pleiotropic Polymorphisms for Stature, Fatness and Reproduction in Beef Cattle , 2014, PLoS genetics.

[23]  O. Franco,et al.  Nutrition and healthy ageing: the key ingredients , 2014, Proceedings of the Nutrition Society.

[24]  C. Peichel,et al.  Pleiotropic effects of a single gene on skeletal development and sensory system patterning in sticklebacks , 2014, EvoDevo.

[25]  Peter H Whincup,et al.  Sarcopenic Obesity and Risk of Cardiovascular Disease and Mortality: A Population-Based Cohort Study of Older Men , 2014, Journal of the American Geriatrics Society.

[26]  A. Yashin,et al.  Morbidity risks among older adults with pre-existing age-related diseases , 2013, Experimental Gerontology.

[27]  S Jay Olshansky,et al.  Substantial health and economic returns from delayed aging may warrant a new focus for medical research. , 2013, Health affairs.

[28]  H. Snieder,et al.  Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals , 2013, Diabetologia.

[29]  A. Yashin,et al.  How the quality of GWAS of human lifespan and health span can be improved , 2013, Front. Genet..

[30]  Carlos Caldas,et al.  Genetic heterogeneity in breast cancer: the road to personalized medicine? , 2013, BMC Medicine.

[31]  S. Purcell,et al.  Pleiotropy in complex traits: challenges and strategies , 2013, Nature Reviews Genetics.

[32]  James J. Anderson,et al.  Mortality Increase in Late-Middle and Early-Old Age: Heterogeneity in Death Processes as a New Explanation , 2013, Demography.

[33]  P. Chedraui,et al.  Nutrition and health during mid-life: searching for solutions and meeting challenges for the aging population , 2013, Climacteric : the journal of the International Menopause Society.

[34]  A. Yashin,et al.  How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data , 2012, Front. Gene..

[35]  F. Thinnes.  Why cancer survivors have a lower risk of Alzheimer disease. , 2012, Molecular genetics and metabolism.

[36]  G. Rennert,et al.  The Rationale for Delaying Aging and the Prevention of Age-Related Diseases , 2012, Rambam Maimonides medical journal.

[37]  B. Singh,et al.  Experimental Evidence for Nutrition Regulated Stress Resistance in Drosophila ananassae , 2012, PloS one.

[38]  A. Yashin,et al.  How genes influence life span: the biodemography of human survival. , 2012, Rejuvenation research.

[39]  A. Yashin,et al.  The quadratic hazard model for analyzing longitudinal data on aging, health, and the life span. , 2012, Physics of life reviews.

[40]  C. Finch,et al.  Early cohort mortality predicts the rate of aging in the cohort: a historical analysis , 2012, Journal of Developmental Origins of Health and Disease.

[41]  N. Barzilai,et al.  The Critical Role of Metabolic Pathways in Aging , 2012, Diabetes.

[42]  L. Pruimboom,et al.  Chronic inflammatory diseases are stimulated by current lifestyle: how diet, stress levels and medication prevent our body from recovering , 2012, Nutrition & Metabolism.

[43]  R. Holt,et al.  The genetics of phenotypic plasticity. X. Variation versus uncertainty , 2012, Ecology and evolution.

[44]  J. Shega,et al.  Persistent Pain and Frailty: A Case for Homeostenosis , 2012, Journal of the American Geriatrics Society.

[45]  Ginny Allain,et al.  Personalized medicine. , 2012, MLO: medical laboratory observer.

[46]  Xiaofeng Zhu,et al.  Detecting rare variants. , 2012, Methods in molecular biology.

[47]  E. Demerath,et al.  A genome-wide association study of aging , 2011, Neurobiology of Aging.

[48]  Wei Pan,et al.  Comparison of statistical tests for disease association with rare variants , 2011, Genetic epidemiology.

[49]  I. Akushevich,et al.  Joint Analysis of Health Histories, Physiological State, and Survival , 2011 .

[50]  S. Cuzzocrea,et al.  Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity. , 2011, Molecular aspects of medicine.

[51]  R. Vasan,et al.  Next-generation genome-wide association studies: time to focus on phenotype? , 2011, Circulation. Cardiovascular genetics.

[52]  A. Yashin,et al.  Trade‐off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan , 2011, Aging cell.

[53]  K. Land,et al.  Heterogeneity in the Strehler-Mildvan General Theory of Mortality and Aging , 2011, Demography.

[54]  M. Niculescu,et al.  Nutritional influence on epigenetics and effects on longevity , 2011, Current opinion in clinical nutrition and metabolic care.

[55]  Anatoli I. Yashin,et al.  Repeated resuscitation: How lifesaving alters life tables , 1987, Demography.

[56]  A. Yashin,et al.  Evaluation of genotype-specific survival using joint analysis of genetic and non-genetic subsamples of longitudinal data , 2011, Biogerontology.

[57]  Eleftheria Zeggini,et al.  Rare variant association analysis methods for complex traits. , 2010, Annual review of genetics.

[58]  David Hamerman,et al.  Can biogerontologists and geriatricians unite to apply aging science to health care in the decade ahead? , 2010, The journals of gerontology. Series A, Biological sciences and medical sciences.

[59]  J. Houwing-Duistermaat,et al.  Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity , 2010, Proceedings of the National Academy of Sciences.

[60]  A. Yashin,et al.  Trade-offs between cancer and other diseases: do they exist and influence longevity? , 2010, Rejuvenation research.

[61]  A. Wienke.  Frailty Models in Survival Analysis , 2010 .

[62]  Fredrik Barrenäs,et al.  Network properties of human disease genes with pleiotropic effects , 2010, BMC Systems Biology.

[63]  Jason H. Moore,et al.  Missing heritability and strategies for finding the underlying causes of complex disease , 2010, Nature Reviews Genetics.

[64]  Sudha Seshadri,et al.  A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. , 2010, The journals of gerontology. Series A, Biological sciences and medical sciences.

[65]  J. Vaupel,et al.  The impact of heterogeneity in individual frailty on the dynamics of mortality , 1979, Demography.

[66]  É. Bourg.  Hormesis, aging and longevity , 2009 .

[67]  N. Aubin-Horth,et al.  Genomic reaction norms: using integrative biology to understand molecular mechanisms of phenotypic plasticity , 2009, Molecular ecology.

[68]  Igor Akushevich,et al.  Genetic model for longitudinal studies of aging, health, and longevity and its potential application to incomplete data. , 2009, Journal of theoretical biology.

[69]  N. Goldman,et al.  Unobserved Heterogeneity Can Confound the Effect of Education on Mortality , 2009, Mathematical population studies.

[70]  A. Yashin,et al.  Trade-off between cancer and aging: What role do other diseases play? Evidence from experimental and human population studies , 2009, Mechanisms of Ageing and Development.

[71]  Richard A. Miller.  "Dividends" from research on aging--can biogerontologists, at long last, find something useful to do? , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[72]  R. Cooper.  Which factors confound or modify the relationship between body weight and mortality? , 2008, International Journal of Obesity.

[73]  L. Partridge,et al.  New model of health promotion and disease prevention for the 21st century , 2008, BMJ : British Medical Journal.

[74]  A. Yashin,et al.  The U-shaped response of initial mortality in Caenorhabditis elegans to mild heat shock: does it explain recent trends in human mortality? , 2008, The journals of gerontology. Series A, Biological sciences and medical sciences.

[75]  M. Kuzuya,et al.  J‐SHAPED RELATIONSHIP BETWEEN RESTING PULSE RATE AND ALL‐CAUSE MORTALITY IN COMMUNITY‐DWELLING OLDER PEOPLE WITH DISABILITIES , 2008, Journal of the American Geriatrics Society.

[76]  A. Yashin,et al.  Body Mass Index and Nine‐Year Mortality in Disabled and Nondisabled Older U.S. Individuals , 2008, Journal of the American Geriatrics Society.

[77]  D. Kiel,et al.  Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study , 2007, BMC Medical Genetics.

[78]  V. Tikhonoff,et al.  Serum uric acid shows a J-shaped trend with coronary mortality in non-insulin-dependent diabetic elderly people. The CArdiovascular STudy in the ELderly (CASTEL) , 2007, Acta Diabetologica.

[79]  Kenny Q. Ye,et al.  Buffering Mechanisms in Aging: A Systems Approach Toward Uncovering the Genetic Component of Aging , 2007, PLoS Comput. Biol..

[80]  J. Filipovský,et al.  Diastolic Blood Pressure and Mortality in the Elderly With Cardiovascular Disease , 2007, Hypertension.

[81]  A. Bergman,et al.  Genetic Determinants of Human Health Span and Life Span: Progress and New Opportunities , 2007, PLoS genetics.

[82]  A. Barabasi,et al.  The human disease network , 2007, Proceedings of the National Academy of Sciences.

[83]  D. Nussey,et al.  The evolutionary ecology of individual phenotypic plasticity in wild populations , 2007, Journal of evolutionary biology.

[84]  V. Loeschcke,et al.  Longevity and the stress response in Drosophila , 2007, Experimental Gerontology.

[85]  P. Parsons.  The ecological stress theory of aging and hormesis: an energetic evolutionary model , 2007, Biogerontology.

[86]  Konstantin G. Arbeev,et al.  The accuracy of statistical estimates in genetic studies of aging can be significantly improved , 2007, Biogerontology.

[87]  Gerard J. van den Berg,et al.  The Unobserved Heterogeneity Distribution in Duration Analysis , 2007 .

[88]  Burton H Singer,et al.  Reduction in Allostatic Load in Older Adults Is Associated With Lower All-Cause Mortality Risk: MacArthur Studies of Successful Aging , 2006, Psychosomatic medicine.

[89]  A. Bergman,et al.  Lipoprotein Genotype and Conserved Pathway for Exceptional Longevity in Humans , 2006, PLoS biology.

[90]  L. Tremolizzo,et al.  Is the inverse association between Alzheimer's disease and cancer the result of a different propensity to methylate DNA? , 2006, Medical hypotheses.

[91]  L. Partridge,et al.  Science fact and the SENS agenda , 2005 .

[92]  S. Jazwinski,et al.  The retrograde response links metabolism with stress responses, chromatin-dependent gene activation, and genome stability in yeast aging. , 2005, Gene.

[93]  S. Westin,et al.  Thresholds for normal blood pressure and serum cholesterol , 2005, BMJ : British Medical Journal.

[94]  L. Partridge,et al.  Science fact and the SENS agenda. What can we reasonably expect from ageing research? , 2005, EMBO Reports.

[95]  P. Parsons.  Life span: does the limit to survival depend upon metabolic efficiency under stress? , 2004, Biogerontology.

[96]  A. Yashin,et al.  Stress resistance declines with age: analysis of data from a survival experiment with Drosophila melanogaster , 2004, Biogerontology.

[97]  T. Perls,et al.  Morbidity profiles of centenarians: survivors, delayers, and escapers. , 2003, The journals of gerontology. Series A, Biological sciences and medical sciences.

[98]  R. Collins,et al.  Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies , 2002, The Lancet.

[99]  S. Jazwinski.  Biological aging research today: potential, peeves, and problems , 2002, Experimental Gerontology.

[100]  Kyle Duke,et al.  Transcriptional Profile of Aging in C. elegans , 2002, Current Biology.

[101]  A. Yashin,et al.  Individual aging and mortality rate: How are they related? , 2002, Social biology.

[102]  J. Colgrove,et al.  The McKeown thesis: a historical controversy and its enduring influence. , 2002, American journal of public health.

[103]  Bruce G. Link,et al.  McKeown and the idea that social conditions are fundamental causes of disease. , 2002, American journal of public health.

[104]  G. Lithgow,et al.  Stress resistance as a determinate of C. elegans lifespan , 2002, Mechanisms of Ageing and Development.

[105]  A. Yashin,et al.  New age patterns of survival improvement in Sweden: do they characterize changes in individual aging? , 2002, Mechanisms of Ageing and Development.

[106]  François Gueyffier,et al.  J-Shaped Relationship between Blood Pressure and Mortality in Hypertensive Patients: New Insights from a Meta-Analysis of Individual-Patient Data , 2002, Annals of Internal Medicine.

[107]  J. Cypser,et al.  Multiple stressors in Caenorhabditis elegans induce stress hormesis and extended longevity. , 2002, The journals of gerontology. Series A, Biological sciences and medical sciences.

[108]  Sc Prospective,et al.  Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies , 2002 .

[109]  A. Yashin,et al.  The new trends in survival improvement require a revision of traditional gerontological concepts , 2001, Experimental Gerontology.

[110]  J P Bunker,et al.  The role of medical care in contributing to health improvements within societies. , 2001, International journal of epidemiology.

[111]  Dmitri A. Jdanov,et al.  Have the oldest old adults ever been frail in the past? A hypothesis that explains modern trends in survival. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[112]  C. Franceschi,et al.  Paradoxes in longevity: sequence analysis of mtDNA haplogroup J in centenarians , 2001, European Journal of Human Genetics.

[113]  J W Rowe,et al.  Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[114]  S. Olshansky,et al.  Heterogeneity and its biodemographic implications for longevity and mortality , 2001, Experimental Gerontology.

[115]  P. Kapahi,et al.  Evolution, stress, and longevity , 2000, Journal of anatomy.

[116]  A. Yashin,et al.  Genes and longevity: lessons from studies of centenarians. , 2000, The journals of gerontology. Series A, Biological sciences and medical sciences.

[117]  N. Yasuda,et al.  A U‐Shaped Association Between Home Systolic Blood Pressure and Four‐Year Mortality in Community‐Dwelling Older Men , 1999, Journal of the American Geriatrics Society.

[118]  A. Yashin,et al.  Dependent Hazards in Multivariate Survival Problems , 1999 .

[119]  A. Yashin,et al.  Genes, demography, and life span: the contribution of demographic data in genetic studies on aging and longevity. , 1999, American journal of human genetics.

[120]  P Hougaard,et al.  Multi-state Models: A Review , 1999, Lifetime data analysis.

[121]  P. Palatini,et al.  Need for a revision of the normal limits of resting heart rate. , 1999, Hypertension.

[122]  A. Yashin,et al.  What Difference Does the Dependence Between Durations Make? Insights for Population Studies of Aging , 1999, Lifetime data analysis.

[123]  A. Yashin,et al.  Biodemographic trajectories of longevity. , 1998, Science.

[124]  G. Mcclearn,et al.  Mortality and biomarkers of aging in heterogeneous stock (HS) mice. , 1998, The journals of gerontology. Series A, Biological sciences and medical sciences.

[125]  A. Yashin,et al.  Age‐related changes of the 3′APOB‐VNTR genotype pool in ageing cohorts , 1998, Annals of human genetics.

[126]  M. Heo,et al.  Hypothesis concerning the U-shaped relation between body mass index and mortality. , 1997, American journal of epidemiology.

[127]  J. Mackenbach.  The contribution of medical care to mortality decline: McKeown revisited. , 1996, Journal of clinical epidemiology.

[128]  P. Parsons.  The limit to human longevity: an approach through a stress theory of ageing , 1996, Mechanisms of Ageing and Development.

[129]  J. Troncale.  The aging process. Physiologic changes and pharmacologic implications. , 1996, Postgraduate medicine.

[130]  E. Frongillo,et al.  The relationship between body weight and mortality: a quantitative analysis of combined information from existing studies. , 1996, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[131]  P. Hougaard,et al.  Frailty models for survival data , 1995, Lifetime data analysis.

[132]  A. Yashin,et al.  Survival of related individuals: an extension of some fundamental results of heterogeneity analysis. , 1995, Mathematical population studies.

[133]  A. Yashin,et al.  Correlated individual frailty: an advantageous approach to survival analysis of bivariate data. , 1995, Mathematical population studies.

[134]  K Borch-Johnsen,et al.  Heterogeneity models of disease susceptibility, with application to diabetic nephropathy. , 1994, Biometrics.

[135]  O. Aalen.  Effects of frailty in survival analysis , 1994, Statistical methods in medical research.

[136]  A. Yashin,et al.  A duality in aging: the equivalence of mortality models based on radically different concepts , 1994, Mechanisms of Ageing and Development.

[137]  D. E. Grobbee,et al.  J-shaped relation between change in diastolic blood pressure and progression of aortic atherosclerosis , 1994, The Lancet.

[138]  H. Kesteloot.  Nutrition and life expectancy of populations. , 1993, Acta Cardiologica.

[139]  J. Vaupel,et al.  Slowing of mortality rates at older ages in large medfly cohorts. , 1992, Science.

[140]  J. Riggs.  Aging and mortality: Manisfestations of natural ‘non-selaction’ , 1992, Mechanisms of Ageing and Development.

[141]  S. Ďoubal,et al.  Influence of aging rate change on mortality curves , 1990, Mechanisms of Ageing and Development.

[142]  A. Yashin,et al.  Evaluating the effects of observed and unobserved diffusion processes in survival analysis of longitudinal data , 1986 .

[143]  H. Munro,et al.  Nutrition and aging , 1986 .

[144]  A. Yashin,et al.  Heterogeneity's ruses: some surprising effects of selection on population dynamics. , 1985, The American statistician.

[145]  A. C. Economos,et al.  Rate of aging, rate of dying and the mechanism of mortality. , 1982, Archives of gerontology and geriatrics.

[146]  Alfin-Slater Rb.  Nutrition and aging: introduction. , 1979 .

[147]  M A Woodbury,et al.  A random-walk model of human mortality and aging. , 1977, Theoretical population biology.

[148]  T. Mckeown,et al.  An interpretation of the decline of mortality in England and Wales during the twentieth century. , 1975, Population studies.

[149]  F. Brimblecombe.  IMPROVEMENTS IN HEALTH CARE , 1975, Developmental Medicine & Child Neurology.

[150]  B. Strehler,et al.  General theory of mortality and aging. , 1960, Science.

[151]  M. DePamphilis,et al.  HUMAN DISEASE , 1957, The Ulster Medical Journal.

[152]  Benjamin Gompertz,et al.  XXIV. On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies. In a letter to Francis Baily, Esq. F. R. S. &c , 1825, Philosophical Transactions of the Royal Society of London.