CLASSICAL AND MODERN CONTROL STRATEGIES IN GLUCOSE-INSULIN STABILIZATION

Abstract This paper presents an analysis of classical and modern control methods for blood glucose control of diabetic patients under intensive care. Employing a modified two- compartment model proposed by Bergman, et al. (1979), linear feedback control law leads to a fully symbolic solution. In case of nonlinear approach, considering glucose injection as the only control variable and using Pontryagin's maximum principle, a symbolic-numeric solution has been achieved. As modern control strategy, optimal glucose-insulin control in the H 2 /H ∞ -space is presented using LQ and disturbance rejection LQ methods, which result in a numerical solution to the control problem.

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