ER stress in human hepatic cells treated with Efavirenz: mitochondria again.

[1]  R. Weber,et al.  Antiretroviral drug-related liver mortality among HIV-positive persons in the absence of hepatitis B or C virus coinfection: the data collection on adverse events of anti-HIV drugs study. , 2013, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[2]  M. Y. Lau,et al.  Human immunodeficiency virus protease inhibitors modulate Ca2+ homeostasis and potentiate alcoholic stress and injury in mice and primary mouse and human hepatocytes , 2012, Hepatology.

[3]  A. Hoepelman,et al.  No increased risk of hepatotoxicity in long‐term use of nonnucleoside reverse transcriptase inhibitors in HIV‐infected patients , 2012, HIV medicine.

[4]  J. Esplugues,et al.  Profile of stress and toxicity gene expression in human hepatic cells treated with Efavirenz. , 2012, Antiviral research.

[5]  M. Núñez,et al.  Liver Toxicity of Antiretroviral Drugs , 2012, Seminars in Liver Disease.

[6]  B. Clotet,et al.  Liver Toxicity of Initial Antiretroviral Drug Regimens Including Two Nucleoside Analogs Plus One Non-Nucleoside Analog or One Ritonavir-Boosted Protease Inhibitor in HIV/HCV-Coinfected Patients , 2012, HIV clinical trials.

[7]  J. Esplugues,et al.  Mitochondrial interference by anti-HIV drugs: mechanisms beyond Pol-γ inhibition. , 2011, Trends in pharmacological sciences.

[8]  R. Berge,et al.  Tetradecylthioacetic acid inhibits proliferation of human SW620 colon cancer cells - gene expression profiling implies endoplasmic reticulum stress , 2011, Lipids in Health and Disease.

[9]  J. Esplugues,et al.  Compromising mitochondrial function with the antiretroviral drug efavirenz induces cell survival‐promoting autophagy , 2011, Hepatology.

[10]  D. Neau,et al.  Impact of HAART exposure and associated lipodystrophy on advanced liver fibrosis in HIV/HCV‐coinfected patients , 2011, Journal of viral hepatitis.

[11]  N. Kaplowitz,et al.  The contribution of endoplasmic reticulum stress to liver diseases , 2011, Hepatology.

[12]  Randal J. Kaufman,et al.  Endoplasmic reticulum stress in liver disease. , 2011, Journal of hepatology.

[13]  N. Apostolova,et al.  Enhanced oxidative stress and increased mitochondrial mass during Efavirenz‐induced apoptosis in human hepatic cells , 2010, British journal of pharmacology.

[14]  J. Esplugues,et al.  Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells , 2010, Hepatology.

[15]  J. Rodés,et al.  Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia–reperfusion , 2010, Cell Death and Disease.

[16]  T. Asselah,et al.  In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C , 2010, The Journal of pathology.

[17]  F. Maggiolo.  Efavirenz: a decade of clinical experience in the treatment of HIV , 2009, The Journal of antimicrobial chemotherapy.

[18]  Lixin Sun,et al.  HIV protease inhibitor lopinavir-induced TNF-alpha and IL-6 expression is coupled to the unfolded protein response and ERK signaling pathways in macrophages. , 2009, Biochemical pharmacology.

[19]  J. Liu,et al.  The HIV protease inhibitor saquinavir induces endoplasmic reticulum stress, autophagy, and apoptosis in ovarian cancer cells. , 2009, Gynecologic oncology.

[20]  M. Rossi,et al.  Chlorhexidine-induced apoptosis or necrosis in L929 fibroblasts: A role for endoplasmic reticulum stress. , 2009, Toxicology and applied pharmacology.

[21]  L. Glimcher,et al.  Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1 , 2008, Science.

[22]  C. Ji.  Dissection of endoplasmic reticulum stress signaling in alcoholic and non‐alcoholic liver injury , 2008, Journal of gastroenterology and hepatology.

[23]  C. Oliveira,et al.  Involvement of mitochondria in endoplasmic reticulum stress‐induced apoptotic cell death pathway triggered by the prion peptide PrP106–126 , 2007, Journal of neurochemistry.

[24]  Robert H. Shoemaker,et al.  Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo , 2007, Clinical Cancer Research.

[25]  Y. Yoon,et al.  Thapsigargin induces biphasic fragmentation of mitochondria through calcium‐mediated mitochondrial fission and apoptosis , 2007, Journal of cellular physiology.

[26]  Chi‐Hwa Wang,et al.  Growing tissue-like constructs with Hep3B/HepG2 liver cells on PHBV microspheres of different sizes. , 2007, Journal of biomedical materials research. Part B, Applied biomaterials.

[27]  R. Lotan,et al.  Induction of endoplasmic reticulum stress by the pro-apoptotic retinoid N-(4-Hydroxyphenyl)retinamide via a reactive oxygen species-dependent mechanism in human head and neck cancer cells , 2007, Cancer biology & therapy.

[28]  J. Pineda,et al.  Liver toxicity induced by non-nucleoside reverse transcriptase inhibitors. , 2007, The Journal of antimicrobial chemotherapy.

[29]  M. Sagi,et al.  Diverse Subcellular Locations of Cryptogein-Induced Reactive Oxygen Species Production in Tobacco Bright Yellow-2 Cells1[W][OA] , 2007, Plant Physiology.

[30]  P. Hylemon,et al.  HIV protease inhibitors activate the unfolded protein response and disrupt lipid metabolism in primary hepatocytes. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[31]  Young Ho Suh,et al.  Mitochondrial dysfunction induces aberrant insulin signalling and glucose utilisation in murine C2C12 myotube cells , 2006, Diabetologia.

[32]  R. V. van Schaik,et al.  Interpatient variability in the pharmacokinetics of the HIV non-nucleoside reverse transcriptase inhibitor efavirenz: the effect of gender, race, and CYP2B6 polymorphism. , 2006, British journal of clinical pharmacology.

[33]  F. Gutiérrez,et al.  Prediction of neuropsychiatric adverse events associated with long-term efavirenz therapy, using plasma drug level monitoring. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[34]  John Calvin Reed,et al.  Endoplasmic reticulum stress: cell life and death decisions. , 2005, The Journal of clinical investigation.

[35]  P. Brookes,et al.  Calcium, ATP, and ROS: a mitochondrial love-hate triangle. , 2004, American journal of physiology. Cell physiology.

[36]  K. Tashima,et al.  Lipid Changes in Patients Initiating Efavirenz- and Indinavir-Based Antiretroviral Regimens , 2003, HIV clinical trials.

[37]  R. Kaufman,et al.  The mammalian unfolded protein response. , 2003, Annual review of biochemistry.

[38]  L. Ellerby,et al.  Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78 , 2002, FEBS letters.

[39]  J. W. Brewer,et al.  PERK mediates cell-cycle exit during the mammalian unfolded protein response. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[40]  P. Cullen,et al.  Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[41]  S. Dooley,et al.  Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism , 2011, Archives of Toxicology.

[42]  C. Oliveira,et al.  ER stress-mediated apoptotic pathway induced by Abeta peptide requires the presence of functional mitochondria. , 2010, Journal of Alzheimer's disease : JAD.

[43]  Jing-Gung Chung,et al.  Capsaicin-induced apoptosis in human hepatoma HepG2 cells. , 2009, Anticancer research.

[44]  Jihyun Song,et al.  Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: a molecular mechanism leading to hepatic insulin resistance. , 2009, Cellular signalling.

[45]  G. Salido,et al.  H2O2-induced changes in mitochondrial activity in isolated mouse pancreatic acinar cells , 2005, Molecular and Cellular Biochemistry.