Bioinformatics and Proteomics Approaches for Aging Research

[1]  Luca Ferrarini,et al.  A more efficient search strategy for aging genes based on connectivity , 2005, Bioinform..

[2]  João Pedro de Magalhães,et al.  HAGR: the Human Ageing Genomic Resources , 2004, Nucleic Acids Res..

[3]  D. Butterfield,et al.  Quantitative proteomics analysis of specific protein expression and oxidative modification in aged senescence-accelerated-prone 8 mice brain , 2004, Neuroscience.

[4]  J. de Magalhães,et al.  GenAge: a genomic and proteomic network map of human ageing , 2004, FEBS letters.

[5]  V. Arango,et al.  Using the Gene Ontology for Microarray Data Mining: A Comparison of Methods and Application to Age Effects in Human Prefrontal Cortex , 2004, Neurochemical Research.

[6]  Cornelia I Bargmann,et al.  Comparing genomic expression patterns across species identifies shared transcriptional profile in aging , 2004, Nature Genetics.

[7]  M. Atanasova,et al.  Age-related changes in the glycation of human aortic elastin , 2003, Experimental Gerontology.

[8]  Stefani N. Thomas,et al.  High-Throughput Proteomic-Based Identification of Oxidatively Induced Protein Carbonylation in Mouse Brain , 2003, Pharmaceutical Research.

[9]  L. Urban,et al.  Single nucleotide polymorphisms: aging and diseases , 2004, Biogerontology.

[10]  V. Bohr,et al.  Gene expression profiling in Werner syndrome closely resembles that of normal aging , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[11]  Hanno Steen,et al.  Development of human protein reference database as an initial platform for approaching systems biology in humans. , 2003, Genome research.

[12]  S. Bae,et al.  Differential expression of the liver proteome in senescence accelerated mice , 2003, Proteomics.

[13]  K. S. Deshpande,et al.  Microarrays and Mass Spectrometry - The Future of Proteomics , 2003 .

[14]  N. Packer,et al.  Proteomic analysis of the genetic premature aging disease Hutchinson Gilford progeria syndrome reveals differential protein expression and glycosylation. , 2003, Journal of proteome research.

[15]  E. Grapsa,et al.  Effect of Dialysis on Plasma Total Antioxidant Capacity and Lipid Peroxidation Products in Patients with End-Stage Renal Failure , 2003, Blood Purification.

[16]  J. Ji,et al.  Proteomic comparison between human young and old brains by two-dimensional gel electrophoresis and identification of proteins , 2003, International Journal of Developmental Neuroscience.

[17]  Gary Ruvkun,et al.  DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism , 2003, Science.

[18]  H. Remmen,et al.  Comparative proteomics: characterization of a two-dimensional gel electrophoresis system to study the effect of aging on mitochondrial proteins , 2003, Mechanisms of Ageing and Development.

[19]  L. Hood.  Systems biology: integrating technology, biology, and computation , 2003, Mechanisms of Ageing and Development.

[20]  Gary Ruvkun,et al.  A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity , 2003, Nature Genetics.

[21]  Martin Vingron,et al.  CORG: a database for COmparative Regulatory Genomics , 2003, Nucleic Acids Res..

[22]  Mike Tyers,et al.  The GRID: The General Repository for Interaction Datasets , 2003, Genome Biology.

[23]  Steven C. Lawlor,et al.  MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data , 2003, Genome Biology.

[24]  Evelyn Strauss,et al.  Science of aging knowledge environment: one-stop shopping for researchers in the field of aging , 2002, Experimental Gerontology.

[25]  M. Mann,et al.  Stable Isotope Labeling by Amino Acids in Cell Culture, SILAC, as a Simple and Accurate Approach to Expression Proteomics* , 2002, Molecular & Cellular Proteomics.

[26]  Matt Kaeberlein,et al.  AGEID: a database of aging genes and interventions , 2002, Mechanisms of Ageing and Development.

[27]  H. Gershon,et al.  Caenorhabditis elegans—a paradigm for aging research: advantages and limitations , 2002, Mechanisms of Ageing and Development.

[28]  R. J. Davenport,et al.  A SAGE KE Primer. , 2001, Science of aging knowledge environment : SAGE KE.

[29]  N. Lee,et al.  Gene expression profile of the aging process in rat liver: normalizing effects of growth hormone replacement. , 2001, Molecular endocrinology.

[30]  J. Dillon,et al.  The Nitrite/Collagen Reaction: Non-Enzymatic Nitration as a Model System for Age-Related Damage , 2001, Connective tissue research.

[31]  H. Gershon,et al.  The budding yeast, Saccharomyces cerevisiae, as a model for aging research: a critical review , 2000, Mechanisms of Ageing and Development.

[32]  T. Nakazawa,et al.  Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. , 2000, The Biochemical journal.

[33]  M. Ashburner,et al.  Gene Ontology: tool for the unification of biology , 2000, Nature Genetics.

[34]  D. Lockhart,et al.  Mitotic misregulation and human aging. , 2000, Science.

[35]  S. Gygi,et al.  Quantitative analysis of complex protein mixtures using isotope-coded affinity tags , 1999, Nature Biotechnology.

[36]  R. Bank,et al.  Ageing and zonal variation in post-translational modification of collagen in normal human articular cartilage. The age-related increase in non-enzymatic glycation affects biomechanical properties of cartilage. , 1998, The Biochemical journal.

[37]  M. Goto,et al.  Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing , 1997, Mechanisms of Ageing and Development.

[38]  C. Kenyon,et al.  daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. , 1997, Science.

[39]  G. Ruvkun,et al.  The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans , 1997, Nature.

[40]  Koutarou D. Kimura,et al.  daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. , 1997, Science.