Acquired resistance to EGFR tyrosine kinase inhibitors alters the metabolism of human head and neck squamous carcinoma cells and xenograft tumours

[1]  M. Haigis,et al.  Mitochondria and Cancer , 2016, Cell.

[2]  A. Shaw,et al.  Molecular Pathways Molecular Pathways : Resistance to Kinase Inhibitors and Implications for Therapeutic Strategies , 2014 .

[3]  P. Johnston,et al.  Cancer drug resistance: an evolving paradigm , 2013, Nature Reviews Cancer.

[4]  J. Waterton,et al.  Acute tumour response to the MEK1/2 inhibitor selumetinib (AZD6244, ARRY-142886) evaluated by non-invasive diffusion-weighted MRI , 2013, British Journal of Cancer.

[5]  B. Al-Lazikani,et al.  A novel serum protein signature associated with resistance to epidermal growth factor receptor tyrosine kinase inhibitors in head and neck squamous cell carcinoma. , 2013, European journal of cancer.

[6]  John M. Asara,et al.  Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway , 2013, Nature.

[7]  Jian Xu,et al.  An evaluation of motion compensation strategies and repeatability for abdominal 1H MR spectroscopy measurements in volunteer studies and clinical trials , 2012, NMR in biomedicine.

[8]  Maria Vinci,et al.  Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation , 2012, BMC Biology.

[9]  P. Ward,et al.  Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. , 2012, Cancer cell.

[10]  J. Griffiths,et al.  Histone deacetylase inhibition increases levels of choline kinase alpha and phosphocholine facilitating non-invasive imaging in human cancers , 2011 .

[11]  M. Agulnik New approaches to EGFR inhibition for locally advanced or metastatic squamous cell carcinoma of the head and neck (SCCHN) , 2012, Medical Oncology.

[12]  Z. Bhujwalla,et al.  Choline metabolism in malignant transformation , 2011, Nature Reviews Cancer.

[13]  A. Chinnaiyan,et al.  Magic angle spinning NMR-based metabolic profiling of head and neck squamous cell carcinoma tissues. , 2011, Journal of proteome research.

[14]  M. Leach,et al.  Exploiting tumor metabolism for non-invasive imaging of the therapeutic activity of molecularly targeted anticancer agents , 2011, Cell cycle.

[15]  Nikhil Wagle,et al.  Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[16]  R. Jain,et al.  Serial magnetic resonance spectroscopy reveals a direct metabolic effect of cediranib in glioblastoma. , 2011, Cancer research.

[17]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[18]  T. Mak,et al.  Regulation of cancer cell metabolism , 2011, Nature Reviews Cancer.

[19]  J. Pouysségur,et al.  Hypoxia and energetic tumour metabolism. , 2011, Current opinion in genetics & development.

[20]  Simon I. R. Lane,et al.  Phosphorylation of Histone H3 in 1- and 2-cell embryos , 2011, Cell cycle.

[21]  A. Balmain,et al.  Guidelines for the welfare and use of animals in cancer research , 2010, British Journal of Cancer.

[22]  J. Ragoussis,et al.  hsa‐miR‐210 is a marker of tumor hypoxia and a prognostic factor in head and neck cancer , 2010, Cancer.

[23]  M. Verschoor,et al.  Mechanisms associated with mitochondrial-generated reactive oxygen species in cancer. , 2010, Canadian journal of physiology and pharmacology.

[24]  G. Castellano,et al.  Tumor and Stem Cell Biology Cancer Research Activation of Phosphatidylcholine Cycle Enzymes in Human Epithelial Ovarian Cancer Cells , 2010 .

[25]  M O Leach,et al.  Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy , 2009, British Journal of Cancer.

[26]  Kevin M. Ryan,et al.  p53 and metabolism , 2009, Nature Reviews Cancer.

[27]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[28]  K. Harrington,et al.  Determinants of response to epidermal growth factor receptor tyrosine kinase inhibition in squamous cell carcinoma of the head and neck , 2009, The Journal of pathology.

[29]  C. Maki,et al.  Transient nutlin-3a treatment promotes endoreduplication and the generation of therapy-resistant tetraploid cells. , 2008, Cancer research.

[30]  B. Chauffert,et al.  Tumor cells can escape DNA‐damaging cisplatin through DNA endoreduplication and reversible polyploidy , 2008, Cell biology international.

[31]  B. Narasimhan,et al.  In vivo 1H magnetic resonance spectroscopy of lactate in patients with stage IV head and neck squamous cell carcinoma. , 2008, International journal of radiation oncology, biology, physics.

[32]  A. Harris,et al.  Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[33]  Ruth Katz,et al.  Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. , 2002, Cancer research.

[34]  R. Day,et al.  Levels of TGF-α and EGFR Protein in Head and Neck Squamous Cell Carcinoma and Patient Survival , 1998 .

[35]  M. Gottesman,et al.  The multidrug resistance phenotype: 31P nuclear magnetic resonance characterization and 2-deoxyglucose toxicity. , 1991, Cancer research.

[36]  S. Eccles,et al.  Molecular markers of response and resistance to EGFR inhibitors in head and neck cancers. , 2013, Frontiers in bioscience.

[37]  S. Eccles,et al.  Tumor spheroid-based migration assays for evaluation of therapeutic agents. , 2013, Methods in molecular biology.

[38]  R. Gillies,et al.  Targeting the metabolic microenvironment of tumors. , 2012, Advances in pharmacology.

[39]  L. Ellis,et al.  Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells. , 2012, Cancer research.

[40]  Amita Shukla-Dave,et al.  Tumor metabolism and perfusion in head and neck squamous cell carcinoma: pretreatment multimodality imaging with 1H magnetic resonance spectroscopy, dynamic contrast-enhanced MRI, and [18F]FDG-PET. , 2012, International journal of radiation oncology, biology, physics.

[41]  D. Yeung,et al.  Monitoring of treatment response after chemoradiotherapy for head and neck cancer using in vivo 1H MR spectroscopy , 2009, European Radiology.

[42]  R. Deberardinis,et al.  The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. , 2008, Cell metabolism.

[43]  R. Day,et al.  Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. , 1998, Journal of the National Cancer Institute.