High frequency of serious infections in patients with panhypopituitarism: a case-control study.

We reviewed the records of 65 patients with panhypopituitarism (PHP) for the frequency and types of infections requiring hospitalization, and documented serious infections in 13 of 65 patients with PHP. The increased frequency of serious infectious diseases in patients with PHP is likely to contribute to increased age-specific mortality.

[1]  W. Summer,et al.  Innate immunity, cytokines, and pulmonary host defense. , 1998, Infectious disease clinics of North America.

[2]  J. Bartlett,et al.  Community-acquired pneumonia in adults: guidelines for management. The Infectious Diseases Society of America. , 1998, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[3]  I. Bérczi Pituitary hormones and immune function , 1997, Acta paediatrica (Oslo, Norway : 1992). Supplement.

[4]  M. Dardenne,et al.  Growth hormone stimulates the proliferation of activated mouse T lymphocytes. , 1997, Endocrinology.

[5]  L. Yu-Lee Molecular Actions of Prolactin in the Immune System , 1997, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[6]  H. Anisman,et al.  Neuroimmune mechanisms in health and disease: 2. Disease. , 1996, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[7]  H. Anisman,et al.  Neuroimmune mechanisms in health and disease: 1. Health. , 1996, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[8]  L. Matera,et al.  Endocrine, paracrine and autocrine actions of prolactin on immune cells. , 1996, Life sciences.

[9]  E. Jaffe,et al.  The effects of growth hormone and insulin-like growth factor I on the immune system of aged female monkeys. , 1996, Endocrinology.

[10]  R. Clayton,et al.  The effect of hypopituitarism on life expectancy. , 1996, The Journal of clinical endocrinology and metabolism.

[11]  D. Margulies,et al.  A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development. , 1995, Immunity.

[12]  M. Chen,et al.  Oestrogen influences CD4+ T-lymphocyte activity in vivo and in vitro in beta 2-microglobulin-deficient mice. , 1995, Immunology.

[13]  F. Holsboer,et al.  Glucocorticoids accelerate anti-T cell receptor-induced T cell growth. , 1995, Journal of immunology.

[14]  K. Syrigos,et al.  Effect of Testosterone Administration, Pre- and Postnatally, on the Immune System of Rats , 1995, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[15]  V. Papadopoulos,et al.  Steroid production in the thymus: implications for thymocyte selection , 1994, The Journal of experimental medicine.

[16]  F. Frey,et al.  [Glucocorticoids and infection]. , 1992, Schweizerische medizinische Wochenschrift.

[17]  R. Derijk,et al.  Neuroendocrine and immunological mechanisms in stress-induced immunomodulation , 1991, The Journal of Steroid Biochemistry and Molecular Biology.

[18]  B. Styrt,et al.  Estrogens and infection. , 1991, Reviews of infectious diseases.

[19]  M. Cisternino,et al.  In vitro and in vivo effect of growth hormone on cytotoxic activity. , 1990, The Journal of pediatrics.

[20]  B. Bengtsson,et al.  Premature mortality due to cardiovascular disease in hypopituitarism , 1990, The Lancet.

[21]  D. Henry,et al.  Effect of treatment with biosynthetic human growth hormone (GH) on peripheral blood lymphocyte populations and function in growth hormone-deficient children. , 1990, The Journal of clinical endocrinology and metabolism.

[22]  N. Chiorazzi,et al.  Regulation of the immune response by sex hormones. I. In vitro effects of estradiol and testosterone on pokeweed mitogen-induced human B cell differentiation. , 1988, Journal of immunology.

[23]  J. Bellanti,et al.  Humoral and Cell-Mediated Immunity in Growth Hormone-Deficient Children: Effect of Therapy with Human Growth Hormone , 1985, Pediatric Research.

[24]  C. Grossman Interactions between the gonadal steroids and the immune system. , 1985, Science.

[25]  H. Reynolds,et al.  Pulmonary host defenses. , 1973, Alcoholism, clinical and experimental research.

[26]  J. Enders Infectious Diseases Society of America , 1969 .

[27]  S. Holland,et al.  Evaluation of the patient with recurrent bacterial infections. , 1998, Annual review of medicine.

[28]  R. Dantzer,et al.  Growth hormone, growth factors and hematopoiesis. , 1996, Hormone research.

[29]  M. Provinciali,et al.  Pituitary-thyroid axis and immune system: a reciprocal neuroendocrine-immune interaction. , 1995, Hormone research.