Abnormal Brain Lateralization in High-Functioning Autism

Disturbances in lateral preference in autism are of interest because of their potential to shed light on brain maturational processes in this disorder. Forty-seven autistic individuals with a history of disordered early language development and 22 autistic individuals with normal early language acquisition were matched with 112 healthy individuals and compared on a standardized measure of lateral preference, the Edinburgh Handedness Inventory. Autistic individuals with a history of early language disturbance showed more atypical cerebral dominance than both healthy participants and autistic individuals with normal early language skills. The data indicated maturational disturbances in establishing lateral preference rather than increased rates of left handedness. Atypical establishment of cerebral dominance may be one cause of disordered language development in autism.

[1]  P. Satz,et al.  Handedness patterns in autism suggest subtypes , 1986, Journal of autism and developmental disorders.

[2]  S. Folstein,et al.  Incorporating language phenotypes strengthens evidence of linkage to autism. , 2001, American journal of medical genetics.

[3]  N. Minshew,et al.  Corpus callosum size in autism , 2000, Neurology.

[4]  N. Rinehart,et al.  Lateralization in Individuals with High-Functioning Autism and Asperger's Disorder: A Frontostriatal Model , 2002, Journal of autism and developmental disorders.

[5]  S. Baron-Cohen,et al.  Handedness in Childhood Autism Shows a Dissociation of Skill and Preference , 1992, Cortex.

[6]  M. Annett,et al.  The theory of an agnosic right shift gene in schizophrenia and autism , 1999, Schizophrenia Research.

[7]  Deborah Dewey,et al.  Hand Preference and Motor Functioning in Children with Autism , 2001, Journal of autism and developmental disorders.

[8]  T. Sigmundsson,et al.  Brain anatomy and sensorimotor gating in Asperger's syndrome. , 2002, Brain : a journal of neurology.

[9]  R. Nebes,et al.  Reliability and validity of some handedness questionnaire items. , 1974, Neuropsychologia.

[10]  Daniel B Hier,et al.  Autism and unfavorable left-right asymmetries of the brain , 1979, Journal of autism and developmental disorders.

[11]  P. Hepper,et al.  Development of lateralized behaviour in the human fetus from 12 to 27 weeks’gestation , 1999, Developmental medicine and child neurology.

[12]  B. Leventhal,et al.  The Autism Diagnostic Observation Schedule—Generic: A Standard Measure of Social and Communication Deficits Associated with the Spectrum of Autism , 2000, Journal of autism and developmental disorders.

[13]  N. Minshew,et al.  Development of the corpus callosum in childhood, adolescence and early adulthood. , 2002, Life sciences.

[14]  M. Prior,et al.  Hemisphere Functioning in Autistic Children , 1979, Cortex.

[15]  E. Courchesne,et al.  Reduced size of corpus callosum in autism. , 1995, Archives of neurology.

[16]  A. Couteur,et al.  Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders , 1994, Journal of autism and developmental disorders.

[17]  S. Bryson.  Chapter 15 Autism and Anomalous Handedness , 1990 .

[18]  H Matsuda,et al.  Single-photon emission computed tomography of the brain in autism: effect of the developmental level. , 2000, Pediatric neurology.

[19]  I. Mcmanus,et al.  Hand preference and hand skill in children with autism , 1996, Journal of autism and developmental disorders.

[20]  E. Kaplan,et al.  The question of left hemisphere dysfunction in infantile autism. , 1984, Psychological bulletin.

[21]  G Dawson,et al.  Development and neural bases of face recognition in autism , 2002, Molecular Psychiatry.

[22]  Nathalie Boddaert,et al.  Functional neuroimaging and childhood autism , 2001, Pediatric Radiology.

[23]  Edward G. Blackstock,et al.  Cerebral asymmetry and the development of early infantile autism , 1978, Journal of autism and childhood schizophrenia.