Niclosamide ethanolamine improves blood glycemic control and reduces hepatic steatosis in mice
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[1] Michael J. MacDonald,et al. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase , 2014, Nature.
[2] G. Shulman,et al. Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler. , 2013, Cell metabolism.
[3] S. Summers,et al. A ceramide-centric view of insulin resistance. , 2012, Cell metabolism.
[4] G. Shulman,et al. Mechanisms for Insulin Resistance: Common Threads and Missing Links , 2012, Cell.
[5] Paul Shekelle,et al. Oral Pharmacologic Treatment of Type 2 Diabetes Mellitus: A Clinical Practice Guideline From the American College of Physicians , 2012, Annals of Internal Medicine.
[6] D. Scudiero,et al. Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancer. , 2011, Journal of the National Cancer Institute.
[7] Wei Chen,et al. Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations. , 2011, Cancer research.
[8] D. Williamson,et al. Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence , 2010, Population health metrics.
[9] Qiang He,et al. Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. , 2010, ACS medicinal chemistry letters.
[10] K. Petersen,et al. Lipid-induced insulin resistance: unravelling the mechanism , 2010, The Lancet.
[11] Y. Tseng,et al. Cellular bioenergetics as a target for obesity therapy , 2010, Nature Reviews Drug Discovery.
[12] M. Komatsu,et al. Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis , 2009, Proceedings of the National Academy of Sciences.
[13] X. Ren,et al. The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. , 2009, Biochemistry.
[14] Kyongbum Lee,et al. Metabolic Flux Analysis of Mitochondrial Uncoupling in 3T3-L1 Adipocytes , 2009, PloS one.
[15] D. Nathan. Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A Consensus Statement of the American Diabetes Association and the European Association for the Study of Diabetes , 2009, Diabetes Care.
[16] F. Schick,et al. High cardiorespiratory fitness is an independent predictor of the reduction in liver fat during a lifestyle intervention in non-alcoholic fatty liver disease , 2008, Gut.
[17] M. Brand,et al. The efficiency of cellular energy transduction and its implications for obesity. , 2008, Annual review of nutrition.
[18] A. Schürmann,et al. Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo. , 2008, Physiological genomics.
[19] G. Shulman,et al. Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance. , 2007, The Journal of clinical investigation.
[20] M. Birnbaum,et al. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. , 2007, Cell metabolism.
[21] L. Scorrano,et al. Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts , 2007, Nature Protocols.
[22] M. Kushmerick,et al. Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo , 2007, Proceedings of the National Academy of Sciences.
[23] S. Kahn,et al. Mechanisms linking obesity to insulin resistance and type 2 diabetes , 2006, Nature.
[24] C. Newgard,et al. Obesity-related derangements in metabolic regulation. , 2006, Annual review of biochemistry.
[25] L. Kozak,et al. Uncoupling proteins: current status and therapeutic prospects , 2005, EMBO reports.
[26] Nimesh Mody,et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes , 2005, Nature.
[27] K. Petersen,et al. Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. , 2005, Diabetes.
[28] T. Asano,et al. Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity. , 2005, Diabetes.
[29] W. Maragos,et al. Mitochondrial uncoupling as a potential therapeutic target in acute central nervous system injury , 2004, Journal of neurochemistry.
[30] D. Befroy,et al. Mechanism of Hepatic Insulin Resistance in Non-alcoholic Fatty Liver Disease* , 2004, Journal of Biological Chemistry.
[31] G. Cline,et al. Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. , 2004, Diabetes.
[32] David Millington,et al. Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance , 2004, Nature Medicine.
[33] K. Inoki,et al. TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival , 2003, Cell.
[34] G. Tomasevic,et al. Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma , 2003, Nature Medicine.
[35] G. Shulman,et al. Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle* , 2002, The Journal of Biological Chemistry.
[36] David Carling,et al. The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways* , 2002, The Journal of Biological Chemistry.
[37] M. Brand,et al. Mitochondrial uncoupling as a target for drug development for the treatment of obesity , 2001, Obesity reviews : an official journal of the International Association for the Study of Obesity.
[38] Margaret S. Wu,et al. Role of AMP-activated protein kinase in mechanism of metformin action. , 2001, The Journal of clinical investigation.
[39] Michael Karin,et al. Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ , 2001, Science.
[40] Y. Terauchi,et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity , 2001, Nature Medicine.
[41] M. Lazar,et al. The hormone resistin links obesity to diabetes , 2001, Nature.
[42] J. Ju,et al. Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice , 2000, Nature Medicine.
[43] Martin D. Brand,et al. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean , 2000, Nature.
[44] M. Owen,et al. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. , 2000, The Biochemical journal.
[45] G. Swan. The pharmacology of halogenated salicylanilides and their anthelmintic use in animals. , 1999, Journal of the South African Veterinary Association.
[46] G. Shulman,et al. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. , 1999, Diabetes.
[47] R. Coleman,et al. AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. , 1999, The Biochemical journal.
[48] P. J. Randle,et al. Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. , 1998, Diabetes/metabolism reviews.
[49] G. A. Fleming,et al. Lactic acidosis in patients with diabetes treated with metformin. , 1998, The New England journal of medicine.
[50] J. D. Smyth,et al. The mechanisms of action of antiprotozoal and anthelmintic drugs in man. , 1997, General pharmacology.
[51] D L Rothman,et al. Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. , 1996, The New England journal of medicine.
[52] B. Spiegelman,et al. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. , 1995, The Journal of clinical investigation.
[53] M. Pelleymounter,et al. Effects of the obese gene product on body weight regulation in ob/ob mice. , 1995, Science.
[54] J. Olefsky,et al. Effects of Weight Loss on Mechanisms of Hyperglycemia in Obese Non-Insulin-Dependent Diabetes Mellitus , 1986, Diabetes.
[55] J. Parascandola. Dinitrophenol and bioenergetics: An historical perspective , 1974, Molecular and Cellular Biochemistry.
[56] E. C. Weinbach,et al. Mechanism of Action of Reagents that uncouple Oxidative Phosphorylation , 1969, Nature.
[57] Yifan Zhang,et al. Oxidative metabolism: glucose versus ketones. , 2013, Advances in experimental medicine and biology.
[58] Robert I. Krieger,et al. HANDBOOK OF PESTICIDE TOXICOLOGY , 2001 .
[59] L. Chan,et al. The db/db mouse, a model for diabetic dyslipidemia: molecular characterization and effects of Western diet feeding. , 2000, Metabolism: clinical and experimental.
[60] K. Uysal,et al. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. , 1997, Nature.
[61] D. Wallace,et al. Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines. , 1996, Methods in enzymology.
[62] M. Maffei,et al. Positional cloning of the mouse obese gene and its human homologue , 1995, Nature.
[63] P. Andrews,et al. The biology and toxicology of molluscicides, Bayluscide. , 1982, Pharmacology & therapeutics.
[64] P. Heytler. Uncouplers of oxidative phosphorylation. , 1980, Pharmacology & therapeutics.
[65] U. Sheth. Mechanisms of anthelmintic action. , 1975, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.