Effect of snake venom derived fibrin glue on the tendon healing in dogs: clinical and biomechanical study

The aim of this study was to evaluate the effect of snake venom derived fibrin glue on the strength oftendon healing in dogs. The deep digital flexor tendon of the 5th digit of 24 thoracic limbs was partially sectioned for adhesive application. On the 7th, 15th, and 30th postoperative day tendons segments were removed for the clinical and biomechanical study. Results indicated that 62.5% of the tendons showed stump retraction and 20.8% moderate to excessive adherence, which affected gliding. The biomechanical evaluation showed that, over time, tendon healing gained progressive resistance for maximum traction and permanent deformations with satisfactory results on the 15th day for rigidity and resilience compared to the other two studied periods. Snake venom derived fibrin glue promotes healing in dog flexor tendon.

[1]  F. Tang,et al.  Ibuprofen inhibition of tendon cell proliferation and upregulation of the cyclin kinase inhibitor p21CIP1 , 2004, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[2]  M. Longaker,et al.  Flexor Tendon Wound Healing In Vitro: Lactate Up-Regulation of TGF-&bgr; Expression and Functional Activity , 2004, Plastic and reconstructive surgery.

[3]  D. Palmes,et al.  Achilles tendon healing: Long‐term biomechanical effects of postoperative mobilization and immobilization in a new mouse model , 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[4]  Matthew J. Silva,et al.  Recent progress in flexor tendon healing , 2002, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

[5]  A. Biewener,et al.  Healing of Achilles Tendon, An Experimental Study: Part 2—Histological, Immunohistological and Ultrasonographic Analysis , 2002, Foot & ankle international.

[6]  A. Grobbelaar,et al.  The Role of Human-Derived Fibrin Sealant in the Reduction of Postoperative Flexor Tendon Adhesion Formation in Rabbits , 2002, Journal of hand surgery.

[7]  D. Nunamaker.  Tendons, Skeletal Muscles, and Ligaments in Health and Disease by D.E. Johnson; B0005.0685 , 2002 .

[8]  C Krettek,et al.  Healing of the Achilles Tendon: An Experimental Study , 2001, Foot & ankle international.

[9]  Santa Maria,et al.  HOMOIMPLANTE ORTOTÓPICO DE TENDÃO CALCÂNEO EM CÃES. CONSERVAÇÃO, ASSEPSIA E IMPLANTAÇÃO ORTHOTOPIC HOMOLOGOUS COMMON CALCANEOUS TENDON GRAFT IN DOGS. CONSERVATION, ASEPSIS AND IMPLANTATION , 2001 .

[10]  C. Ryan,et al.  Effects of 5-fluorouracil on flexor tendon repair. , 2000, The Journal of hand surgery.

[11]  U. Bosch,et al.  [Functional treatment of acute Achilles tendon rupture. A histological, immunohistological and ultrasonographic analysis of the animal model]. , 1999, Der Unfallchirurg.

[12]  A. Sonin.  Tendon Disorders. , 1998, Seminars in musculoskeletal radiology.

[13]  O. Akkus,et al.  Reduction of restrictive adhesions by local aprotinin application and primary sheath repair in surgically traumatized flexor tendons of the rabbit. , 1997, The Journal of hand surgery.

[14]  G. Lundborg,et al.  Tendon repair--cellular activities in rabbit deep flexor tendons and surrounding synovial sheaths and the effects of hyaluronan: an experimental study in vivo and in vitro. , 1997, The Journal of hand surgery.

[15]  R. I. Schwarz.  Modeling tendon morphogenesis in vivo based on cell density signaling in cell culture , 1996, Journal of mathematical biology.

[16]  C. Krettek,et al.  [Functional treatment of acute rupture of the Achilles tendon. An experimental biomechanical study]. , 1995, Der Unfallchirurg.

[17]  Cain Je,et al.  The effect of fibrin sealant on the strength of tendon repair of full thickness tendon lacerations in the rabbit Achilles tendon. , 1994 .

[18]  J. May,et al.  Mechanical analysis of tendon suture techniques. , 1994, The Journal of hand surgery.

[19]  D. A. Lusardi,et al.  The effect of fibrin sealant on the strength of tendon repair of full thickness tendon lacerations in the rabbit Achilles tendon. , 1994, The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons.

[20]  B. Widenfalk,et al.  Fibrin sealant in prevention of flexor tendon adhesions: an experimental study in the rabbit. , 1993, The Journal of hand surgery.

[21]  L. Feehan,et al.  Early tensile properties of healing chicken flexor tendons: early controlled passive motion versus postoperative immobilization. , 1990, The Journal of hand surgery.

[22]  S. Biddulph,et al.  Early postoperative mobilization of flexor tendon injuries using a modification of the Kleinert technique. , 1987, The Journal of hand surgery.

[23]  R. Szabo,et al.  The inhibition of flexor tendon adhesions. , 1986, Bulletin of the Hospital for Joint Diseases Orthopaedic Institute.

[24]  O. Paar,et al.  [Therapy of Achilles tendon rupture in athletes. Advantages of fibrin gluing]. , 1984, Fortschritte der Medizin.

[25]  G. Weseloh,et al.  Fibrinklebung bei Sehnenläsionen — Experimentelle Ergebnisse und klinische Aspekte , 1984 .

[26]  S. Woo,et al.  Effects of early intermittent passive mobilization on healing canine flexor tendons. , 1982, The Journal of hand surgery.

[27]  G. Kapetanos.  The effect of the local corticosteroids on the healing and biomechanical properties of the partially injured tendon. , 1982, Clinical orthopaedics and related research.

[28]  David T. House.  TENDON repair. , 2021, British medical journal.

[29]  M. L. Mason,et al.  THE RATE OF HEALING OF TENDONS* AN EXPERIMENTAL STUDY OF TENSILE STRENGTH , 1941, Annals of surgery.