Selective Retina Therapy with Real-Time Feedback-Controlled Dosimetry for Treating Acute Idiopathic Central Serous Chorioretinopathy in Korean Patients

Purpose To evaluate short-term treatment outcomes following selective retina therapy (SRT) with real-time feedback-controlled dosimetry in Korean patients with acute idiopathic central serous chorioretinopathy (CSC). Methods Sixteen eyes (16 patients) with acute idiopathic CSC (symptom duration < 3 months) were included in this retrospective study. All patients underwent a single session of SRT with real-time feedback-controlled dosimetry. Best-corrected visual acuity (BCVA) and central foveal thickness (CFT) before and 3 months after treatment were examined and compared. Results The logarithm of minimal angle of resolution BCVA was significantly better 3 months after treatment (0.16 ± 0.18) than at the time of diagnosis (0.27 ± 0.18, P = 0.002). Additionally, subretinal fluid had resolved in all 16 eyes 3 months after treatment and CFT was significantly lower 3 months after treatment (215.6 ± 17.9 μm) than at baseline (441.4 ± 124.8 μm, P < 0.001). No notable SRT-related complications were observed during the study period. Conclusion The results of the present study suggest that SRT is a useful therapeutic option for patients with acute idiopathic CSC. Further studies are required to better understand the long-term efficacy of this treatment. This trial is registered with clinical trial registration number NCT03339856.

[1]  D. Boyer,et al.  Chronic central serous chorioretinopathy: photodynamic therapy. , 2004, American journal of ophthalmology.

[2]  Yoo-Ri Chung,et al.  Lack of positive effect of intravitreal bevacizumab in central serous chorioretinopathy: meta-analysis and review , 2013, Eye.

[3]  Yasin Cinar,et al.  Vision-Related Quality of Life in Patients with Chronic Central Serous Chorioretinopathy , 2015, Seminars in ophthalmology.

[4]  R Birngruber,et al.  Selective retina therapy for acute central serous chorioretinopathy , 2010, British Journal of Ophthalmology.

[5]  R Birngruber,et al.  Retinal sparing by selective retinal pigment epithelial photocoagulation. , 1999, Archives of ophthalmology.

[6]  R Birngruber,et al.  Selective retina therapy (SRT): a review on methods, techniques, preclinical and first clinical results. , 2006, Bulletin de la Societe belge d'ophtalmologie.

[7]  J. Pulido,et al.  The incidence of central serous chorioretinopathy in Olmsted County, Minnesota, 1980-2002. , 2008, Ophthalmology.

[8]  R. Brinkmann,et al.  Retinal sensitivity after selective retina therapy (SRT) on patients with central serous chorioretinopathy , 2017, Graefe's Archive for Clinical and Experimental Ophthalmology.

[9]  Ralf Brinkmann,et al.  Selective Retina Therapy in Acute and Chronic-Recurrent Central Serous Chorioretinopathy , 2015, Ophthalmologica.

[10]  Seungbum Kang,et al.  Selective retina therapy with automatic real-time feedback-controlled dosimetry for chronic central serous chorioretinopathy in Korean patients , 2017, Graefe's Archive for Clinical and Experimental Ophthalmology.

[11]  J. Gass.  Photocoagulation treatment of idiopathic central serous choroidopathy. , 1977, Transactions. Section on Ophthalmology. American Academy of Ophthalmology and Otolaryngology.

[12]  M. Amon,et al.  Morphologic Changes in the Foveal Photoreceptor Layer before and after Laser Treatment in Acute and Chronic Central Serous Chorioretinopathy Documented in Spectral-Domain Optical Coherence Tomography , 2013, Journal of ophthalmology.

[13]  Ralf Brinkmann,et al.  RPE damage thresholds and mechanisms for laser exposure in the microsecond-to-millisecond time regimen. , 2005, Investigative ophthalmology & visual science.

[14]  Michael Pircher,et al.  Retinal Pigment Epithelial Features in Central Serous Chorioretinopathy Identified by Polarization-Sensitive Optical Coherence Tomography. , 2016, Investigative ophthalmology & visual science.

[15]  San-Ni Chen,et al.  Subthreshold diode micropulse photocoagulation for the treatment of chronic central serous chorioretinopathy with juxtafoveal leakage. , 2008, Ophthalmology.

[16]  Hong Wang,et al.  Epidemiology of Idiopathic Central Serous Chorioretinopathy in Taiwan, 2001–2006: A Population-based Study , 2013, PloS one.

[17]  A. Gupta,et al.  Spontaneous closure of retinal pigment epithelium microrip in the natural course of central serous chorioretinopathy , 2010, Eye.

[18]  F. Boscia,et al.  Standard-fluence versus low-fluence photodynamic therapy in chronic central serous chorioretinopathy: a nonrandomized clinical trial. , 2010, American journal of ophthalmology.

[19]  E. Aydın.  The efficacy of intravitreal bevacizumab for acute central serous chorioretinopathy. , 2013, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

[20]  J. Gass,et al.  Idiopathic central serous chorioretinopathy. , 1998, Indian journal of ophthalmology.

[21]  R. Brinkmann,et al.  Tissue response of selective retina therapy by means of a feedback‐controlled energy ramping mode , 2014, Clinical & experimental ophthalmology.

[22]  Jae Hui Kim,et al.  Efficacy of Intravitreal Bevacizumab for Recurrent Central Serous Chorioretinopathy in Patients Who Had Previously Responded Well to the Same Therapy. , 2016, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

[23]  D. Palanker,et al.  NONDAMAGING RETINAL LASER THERAPY FOR TREATMENT OF CENTRAL SEROUS CHORIORETINOPATHY: What is the Evidence? , 2017, Retina.

[24]  J. Slakter,et al.  INDOCYANINE GREEN ANGIOGRAPHY‐GUIDED PHOTODYNAMIC THERAPY FOR TREATMENT OF CHRONIC CENTRAL SEROUS CHORIORETINOPATHY: A Pilot Study , 2003, Retina.

[25]  Min Zhao,et al.  SPIRONOLACTONE FOR NONRESOLVING CENTRAL SEROUS CHORIORETINOPATHY , 2015, Retina.

[26]  Y. Tano,et al.  Morphologic changes in acute central serous chorioretinopathy evaluated by fourier-domain optical coherence tomography. , 2008, Ophthalmology.

[27]  Michael D. Ober,et al.  A pilot study of intravitreal bevacizumab for the treatment of central serous chorioretinopathy (Case reports) , 2008, Graefe's Archive for Clinical and Experimental Ophthalmology.

[28]  K. Prause,et al.  Spironolactone in the treatment of central serous chorioretinopathy – a case series , 2014, Graefe's Archive for Clinical and Experimental Ophthalmology.

[29]  Reginald Birngruber,et al.  Optoacoustic real-time dosimetry for selective retina treatment. , 2005, Journal of biomedical optics.

[30]  M. Tso,et al.  Repair after xenon arc photocoagulation. 2. A clinical and light microscopic study of the evolution of retinal lesions in the rhesus monkey. , 1973, American journal of ophthalmology.

[31]  F Hillenkamp,et al.  Microphotocoagulation: selective effects of repetitive short laser pulses. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[32]  K. Oiwa,et al.  Half-dose photodynamic therapy for chronic central serous chorioretinopathy evaluated by focal macular electroretinograms , 2017, Japanese Journal of Ophthalmology.

[33]  J. Donald,et al.  Pathogenesis of Disciform Detachment of the Neuroepithelium: II. Idiopathic Central Serous Choroidopathy , 1967 .

[34]  Min Zhao,et al.  Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis , 2015, Progress in Retinal and Eye Research.

[35]  F. Bandello,et al.  Nonvisible Subthreshold Micropulse Diode Laser (810 nm) Treatment of Central Serous Chorioretinopathy: A Pilot Study , 2008, European journal of ophthalmology.

[36]  S. Moon,et al.  Low-fluence photodynamic therapy versus ranibizumab for chronic central serous chorioretinopathy: one-year results of a randomized trial. , 2014, Ophthalmology.

[37]  F. Türkçü,et al.  Psychological Distress and Poor Quality of Life in Patients with Central Serous Chorioretinopathy , 2014, Seminars in ophthalmology.

[38]  R. Birngruber,et al.  Selective retina therapy in patients with central serous chorioretinopathy , 2006, Graefe's Archive for Clinical and Experimental Ophthalmology.

[39]  R Birngruber,et al.  Subthreshold (retinal pigment epithelium) photocoagulation in macular diseases: a pilot study , 2000, The British journal of ophthalmology.

[40]  Charles P. Lin,et al.  Origin of retinal pigment epithelium cell damage by pulsed laser irradiance in the nanosecond to microsecond time regimen , 2000, Lasers in surgery and medicine.