Stress and Radiation-Induced Activation of Multiple Intracellular Signaling Pathways1
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R. Schmidt-Ullrich | J. Contessa | P. Dent | K. Valerie | M. Hagan | A. Yacoub | R. Carón | G. Amorino | S. Grant | R. Schmidt‐Ullrich
[1] C. Cori,et al. CRYSTALLINE MUSCLE PHOSPHORYLASE , 1942 .
[2] C. Cori,et al. THE ENZYMATIC CONVERSION OF PHOSPHORYLASE a TO b , 1945 .
[3] E. Krebs,et al. The phosphorylase b to a converting enzyme of rabbit skeletal muscle. , 1956, Biochimica et biophysica acta.
[4] Leloir Lf. Regulation of glycogen metabolism. , 1967 .
[5] E. Krebs,et al. An adenosine 3',5'-monophosphate-dependant protein kinase from rabbit skeletal muscle. , 1968, The Journal of biological chemistry.
[6] E. Krebs,et al. Amino acid sequence of the phosphorylated site in rabbit liver glycogen phosphorylase. , 1970, Biochemistry.
[7] E. Sutherland. On the biological role of cyclic AMP. , 1970, JAMA.
[8] E. Krebs,et al. The regulation of skeletal muscle phosphorylase kinase by Ca2+. , 1971, The Journal of biological chemistry.
[9] G. Rindi. [The biological role of cyclic AMP]. , 1971, Acta diabetologica latina.
[10] J. Larner,. COVALENT AND NONCOVALENT CONTROL OF GLYCOGEN SYNTHESIS * , 1973, Annals of the New York Academy of Sciences.
[11] P. Greengard,et al. Ca2+-dependent protein phosphorylation system in membranes from various tissues, and its activation by "calcium-dependent regulator". , 1978, Proceedings of the National Academy of Sciences of the United States of America.
[12] R. Erikson,et al. Avian sarcoma virus-transforming protein, pp60src shows protein kinase activity specific for tyrosine , 1980, Nature.
[13] R. Weinberg,et al. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene , 1982, Nature.
[14] S. Cohen. The receptor for epidermal growth factor functions as a tyrosyl-specific kinase. , 1983, Progress in nucleic acid research and molecular biology.
[15] Jonathan A. Cooper,et al. C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity. , 1984, The Journal of biological chemistry.
[16] M. Berridge,et al. Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factor. , 1984, The Biochemical journal.
[17] R. Cooper,et al. Inositol trisphosphate and diacylglycerol as intracellular second messengers in liver. , 1985, The American journal of physiology.
[18] T. Sturgill,et al. Muscle proteins related to microtubule associated protein-2 are substrates for an insulin-stimulatable kinase. , 1986, Biochemical and biophysical research communications.
[19] J. Maller,et al. Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II , 1988, Nature.
[20] P. Casey,et al. G proteins control diverse pathways of transmembrane signaling 1 , 1989, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[21] M. Waterfield,et al. Structural basis for epidermal growth factor receptor function. , 1989, Progress in growth factor research.
[22] Growth factor signaling pathways: phosphoinositide metabolism and phosphorylation of phospholipase C. , 1989, Cancer cells.
[23] M. Hung,et al. Amplification and rearrangement of c-erb B proto-oncogenes in cancer of human female genital tract. , 1989, Oncogene.
[24] M. Cobb,et al. Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. , 1991, Cell regulation.
[25] H. Michel,et al. Renaturation and partial peptide sequencing of mitogen-activated protein kinase (MAP kinase) activator from rabbit skeletal muscle. , 1992, The Biochemical journal.
[26] K. Valerie,et al. Expression of oestrogen receptor and transforming growth factor-alpha in MCF-7 cells after exposure to fractionated irradiation. , 1992, International journal of radiation biology.
[27] T. Haystead,et al. Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro. , 1992, Science.
[28] David L. Brautigan,et al. Raf-1 activates MAP kinase-kinase , 1992, Nature.
[29] R. Frye. Involvement of G proteins, cytoplasmic calcium, phospholipases, phospholipid-derived second messengers, and protein kinases in signal transduction from mitogenic cell surface receptors. , 1992, Cancer treatment and research.
[30] M. Cobb,et al. Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro. , 1993, The Journal of biological chemistry.
[31] M. Weber,et al. Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase. , 1993, Science.
[32] P. Dent,et al. Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2 , 1993, Molecular and cellular biology.
[33] Nanxin Li,et al. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling , 1993, Nature.
[34] E. Hafen,et al. A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos , 1993, Cell.
[35] Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase. , 1993, Molecular and cellular biology.
[36] M. Wigler,et al. Complex formation between RAS and RAF and other protein kinases. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[37] M. Karin,et al. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. , 1993, Genes & development.
[38] T. Haystead,et al. Functional expression of a MAP kinase kinase in COS cells and recognition by an anti‐STE7/byrl antibody , 1993, FEBS letters.
[39] Sally J. Leevers,et al. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane , 1994, Nature.
[40] E. Peles,et al. ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms. , 1994, The Journal of biological chemistry.
[41] R. Challiss,et al. Phosphoinositide-derived second messengers and the regulation of Ca2+ in vascular smooth muscle. , 1994, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.
[42] Activation of (His)6-Raf-1 in vitro by partially purified plasma membranes from v-Ras-transformed and serum-stimulated fibroblasts. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[43] M. Karin,et al. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain , 1994, Cell.
[44] L Bibbs,et al. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. , 1994, Science.
[45] W. Dougall,et al. Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[46] M. Karin,et al. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. , 1995, Science.
[47] D. Noh,et al. Phosphoinositide-specific phospholipase C and mitogenic signaling. , 1995, Biochimica et biophysica acta.
[48] P. Cohen,et al. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B , 1995, Nature.
[49] C. Marshall,et al. Ras recruits Raf‐1 to the plasma membrane for activation by tyrosine phosphorylation. , 1995, The EMBO journal.
[50] D. Morrison,et al. Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases. , 1995, Science.
[51] Jiahuai Han,et al. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms , 1995, Science.
[52] A. Thomason,et al. Transformation of NIH 3T3 Cells by HER3 or HER4 Receptors Requires the Presence of HER1 or HER2 (*) , 1996, The Journal of Biological Chemistry.
[53] P. Cohen,et al. Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase , 1996, FEBS letters.
[54] J. Baselga,et al. Autocrine Regulation of Membrane Transforming Growth Factor- Cleavage (*) , 1996, The Journal of Biological Chemistry.
[55] K. Carraway. Involvement of the neuregulins and their receptors in cardiac and neural development. , 1996, BioEssays : news and reviews in molecular, cellular and developmental biology.
[56] H. Warenius,et al. Exit from G2 phase after 2 Gy gamma irradiation is faster in radiosensitive human cells with high expression of the RAF1 proto-oncogene. , 1996, Radiation research.
[57] W. A. Yeudall,et al. Growth inhibitory concentrations of EGF induce p21 (WAF1/Cip1) and alter cell cycle control in squamous carcinoma cells. , 1996, Oncogene.
[58] M. Shannon,et al. The effect of ionizing radiation on signal transduction: antibodies to EGF receptor sensitize A431 cells to radiation. , 1996, Biochimica et biophysica acta.
[59] Kuo‐Ting Chang,et al. Enhancement of chemosensitivity by tyrphostin AG825 in high-p185(neu) expressing non-small cell lung cancer cells. , 1996, Cancer research.
[60] R. Schmidt-Ullrich,et al. Radiation-induced autophosphorylation of epidermal growth factor receptor in human malignant mammary and squamous epithelial cells. , 1996, Radiation research.
[61] A. Fornace,et al. Signaling events controlling the molecular response to genotoxic stress. , 1996, EXS.
[62] M. McMahon,et al. Mutations of critical amino acids affect the biological and biochemical properties of oncogenic A-Raf and Raf-1 , 1997, Oncogene.
[63] G. Cooper,et al. Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase , 1997, Molecular and cellular biology.
[64] B. Kavanagh,et al. Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation , 1997, Oncogene.
[65] P. Dent,et al. Association of Grb2 with Sos and Ras with Raf-1 upon gamma irradiation of breast cancer cells , 1997, Oncogene.
[66] R. Kolesnick,et al. Kinase Suppressor of Ras Is Ceramide-Activated Protein Kinase , 1997, Cell.
[67] J. Baselga,et al. PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. , 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.
[68] F. McCormick,et al. Activation of c‐Raf‐1 by Ras and Src through different mechanisms: activation in vivo and in vitro , 1997, The EMBO journal.
[69] J. Downward,et al. Interaction of Ras with phosphoinositide 3-kinase gamma. , 1997, The Biochemical journal.
[70] C. Marshall,et al. Differential Regulation of Raf-1, A-Raf, and B-Raf by Oncogenic Ras and Tyrosine Kinases* , 1997, The Journal of Biological Chemistry.
[71] G. Müller,et al. Regulation of Raf‐1 kinase by TNF via its second messenger ceramide and cross‐talk with mitogenic signalling , 1998, The EMBO journal.
[72] Brendan D. Price,et al. The DNA-Dependent Protein Kinase Participates in the Activation of NFκB Following DNA Damage , 1998 .
[73] A. Lenferink,et al. The oncogenic ErbB-2/ErbB-3 heterodimer is a surrogate receptor of the epidermal growth factor and betacellulin , 1998, Oncogene.
[74] P. Sassone-Corsi,et al. Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[75] D. Alessi,et al. Mitogen‐ and stress‐activated protein kinase‐1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB , 1998, The EMBO journal.
[76] J C Reed,et al. Dysregulation of apoptosis in cancer. , 1998, The cancer journal from Scientific American.
[77] P. Fisher,et al. Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells , 1998, Oncogene.
[78] David I. Smith,et al. Analysis of EGF receptor amplicons reveals amplification of multiple expressed sequences , 1998, Oncogene.
[79] J. Downward,et al. Protein Kinase B Activation and Lamellipodium Formation Are Independent Phosphoinositide 3-Kinase-Mediated Events Differentially Regulated by Endogenous Ras , 1998, Molecular and Cellular Biology.
[80] R. Schmidt-Ullrich,et al. Calcium-dependent stimulation of mitogen-activated protein kinase activity in A431 cells by low doses of ionizing radiation. , 1998, Radiation research.
[81] Joseph Avruch,et al. A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity , 1998, Nature.
[82] P. Graves,et al. 14-3-3 Proteins Are Required for Maintenance of Raf-1 Phosphorylation and Kinase Activity , 1998, Molecular and Cellular Biology.
[83] Specific, irreversible inhibitors of the epidermal growth factor receptor [EGFR] family of tyrosine kinases , 1998 .
[84] Yi-Hsien Su,et al. Suppression of transforming growth factor-β-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway , 1998, Oncogene.
[85] J. Ross,et al. The HER‐2/neu Oncogene in Breast Cancer: Prognostic Factor, Predictive Factor, and Target for Therapy , 1998, Stem cells.
[86] G. Johnson,et al. The TAO of MEKK. , 1998, Frontiers in bioscience : a journal and virtual library.
[87] A. Hamburger,et al. The use of the yeast two hybrid system to evaluate ErbB-3 interactions with SH2 domain containing proteins. , 1998, Biochemical and biophysical research communications.
[88] L. Pirola,et al. Structure and function of phosphoinositide 3-kinases. , 1998, Biochimica et biophysica acta.
[89] C. Dean,et al. Two erbB-4 transcripts are expressed in normal breast and in most breast cancers , 1998, Oncogene.
[90] V. Jordan,et al. The oestrogen-like effect of 4-hydroxytamoxifen on induction of transforming growth factor alpha mRNA in MDA-MB-231 breast cancer cells stably expressing the oestrogen receptor. , 1998, British Journal of Cancer.
[91] C. Marshall,et al. Activation of the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway by Conventional, Novel, and Atypical Protein Kinase C Isotypes , 1998, Molecular and Cellular Biology.
[92] J. Troppmair,et al. Activation of NF-κB by oncogenic Raf in HEK 293 cells occurs through autocrine recruitment of the stress kinase cascade , 1998, Oncogene.
[93] P. Besmer,et al. Kit signaling through PI 3‐kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation , 1998, The EMBO journal.
[94] A. Sharrocks,et al. Differential targeting of MAP kinases to the ETS‐domain transcription factor Elk‐1 , 1998, The EMBO journal.
[95] R. Epstein,et al. Proxy activation of protein ErbB2 by heterologous ligands implies a heterotetrameric mode of receptor tyrosine kinase interaction. , 1998, The Biochemical journal.
[96] Gordon Mills,et al. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC , 1998, Current Biology.
[97] A. Bridges. The rationale and strategy used to develop a series of highly potent, irreversible, inhibitors of the epidermal growth factor receptor family of tyrosine kinases. , 1999, Current medicinal chemistry.
[98] J. Settleman,et al. The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis. , 1999, Genes & development.
[99] U. Kikkawa,et al. Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9. , 1999, Biochemical and biophysical research communications.
[100] A. Hamburger,et al. ErbB‐2 kinase is required for constitutive stat 3 activation in malignant human lung epithelial cells , 1999, International journal of cancer.
[101] R. Schmidt-Ullrich,et al. Roles for basal and stimulated p21(Cip-1/WAF1/MDA6) expression and mitogen-activated protein kinase signaling in radiation-induced cell cycle checkpoint control in carcinoma cells. , 1999, Molecular biology of the cell.
[102] G. Cooper,et al. B-Raf Inhibits Programmed Cell Death Downstream of Cytochrome c Release from Mitochondria by Activating the MEK/Erk Pathway , 1999, Molecular and Cellular Biology.
[103] R. Davis,et al. Signal transduction by the c-Jun N-terminal kinase. , 1999, Biochemical Society symposium.
[104] P. Agostinis,et al. JNK/SAPK activation by platelet-derived growth factor in A431 cells requires both the phospholipase C-gamma and the phosphatidylinositol 3-kinase signaling pathways of the receptor. , 1999, Biochemical and biophysical research communications.
[105] Derek W. Abbott,et al. Mitogen-activated Protein Kinase Kinase 2 Activation Is Essential for Progression through the G2/M Checkpoint Arrest in Cells Exposed to Ionizing Radiation* , 1999, The Journal of Biological Chemistry.
[106] T. Grunt,et al. Expression of c-erbB-41HER4 Is Regulated in T47D Breast Carcinoma Cells by Retinoids and Vitamin D31 , 1999 .
[107] R. Schmidt-Ullrich,et al. Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death. , 1999, Molecular biology of the cell.
[108] Brian A. Hemmings,et al. Domain Swapping Used To Investigate the Mechanism of Protein Kinase B Regulation by 3-Phosphoinositide-Dependent Protein Kinase 1 and Ser473 Kinase , 1999, Molecular and Cellular Biology.
[109] Yoshiyuki Kuchino,et al. Regulation of c-Myc through Phosphorylation at Ser-62 and Ser-71 by c-Jun N-Terminal Kinase* , 1999, The Journal of Biological Chemistry.
[110] A. Mathieu,et al. Role of PI3-kinase in Bcl-X induction and apoptosis inhibition mediated by IL-3 or IGF-1 in Baf-3 cells , 1999, Cell Death and Differentiation.
[111] C. M. Davenport,et al. Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. , 1999, Science.
[112] M. Vandenplas,et al. Atypical PKC ζ is activated by ceramide, resulting in coactivation of NF‐κb/JNK kinase and cell survival , 1999 .
[113] D. Baldwin,et al. RIP2 Is a Raf1-activated Mitogen-activated Protein Kinase Kinase* , 1999, The Journal of Biological Chemistry.
[114] E. Vellenga,et al. Extracellular-regulated kinase 1/2, Jun N-terminal kinase, and c-Jun are involved in NF-kappa B-dependent IL-6 expression in human monocytes. , 1999, Journal of immunology.
[115] M. Diaz-Meco,et al. Inactivation of the Inhibitory κB Protein Kinase/Nuclear Factor κB Pathway by Par-4 Expression Potentiates Tumor Necrosis Factor α-induced Apoptosis* , 1999, The Journal of Biological Chemistry.
[116] K. Moelling,et al. Phosphorylation and regulation of Raf by Akt (protein kinase B). , 1999, Science.
[117] J. Barnard,et al. Heparin Binding Epidermal Growth Factor-like Growth Factor Is a Transforming Growth Factor β-Regulated Gene in Intestinal Epithelial Cells , 1999 .
[118] Bernhard O. Palsson,et al. Cancer cell lines , 1999 .
[119] M. Serrano,et al. The downregulation of the pro‐apoptotic protein Par‐4 is critical for Ras‐induced survival and tumor progression , 1999, The EMBO journal.
[120] H. Wakita,et al. Activation of Epidermal Growth Factor Receptor Promotes Late Terminal Differentiation of Cell-Matrix Interaction-disrupted Keratinocytes* , 1999, The Journal of Biological Chemistry.
[121] Heparin binding epidermal growth factor-like growth factor is a transforming growth factor beta-regulated gene in intestinal epithelial cells. , 1999, Biochemical and biophysical research communications.
[122] D. Stern,et al. Expression of dominant-negative ErbB2 in the mammary gland of transgenic mice reveals a role in lobuloalveolar development and lactation , 1999, Oncogene.
[123] J. Hancock,et al. Interactions of c-Raf-1 with phosphatidylserine and 14-3-3 , 1999, Oncogene.
[124] Y. Yarden,et al. The C‐terminus of the kinase‐defective neuregulin receptor ErbB‐3 confers mitogenic superiority and dictates endocytic routing , 1999, The EMBO journal.
[125] S. Yeh,et al. From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[126] R. Schmidt-Ullrich,et al. The inducible expression of dominant-negative epidermal growth factor receptor-CD533 results in radiosensitization of human mammary carcinoma cells. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.
[127] T. Grunt,et al. Expression of c-erbB-4/HER4 is regulated in T47D breast carcinoma cells by retinoids and vitamin D3. , 1999, Biochemical and biophysical research communications.
[128] Monilola A. Olayioye,et al. NDF/heregulin-induced cell cycle changes and apoptosis in breast tumour cells: role of PI3 kinase and p38 MAP kinase pathways , 1999, Oncogene.
[129] C. Tournier,et al. The MKK7 Gene Encodes a Group of c-Jun NH2-Terminal Kinase Kinases , 1999, Molecular and Cellular Biology.
[130] G Bartsch,et al. Epidermal growth factor (EGF) receptor blockade inhibits the action of EGF, insulin-like growth factor I, and a protein kinase A activator on the mitogen-activated protein kinase pathway in prostate cancer cell lines. , 1999, Cancer research.
[131] J. Contessa,et al. Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells , 1999, Oncogene.
[132] V. Rangnekar,et al. Negative regulation of Par-4 by oncogenic Ras is essential for cellular transformation , 1999, Oncogene.
[133] W. Earnshaw,et al. Induction of apoptosis by cancer chemotherapy. , 2000, Experimental cell research.
[134] H. Hosick,et al. Blocking HER-2/HER-3 function with a dominant negative form of HER-3 in cells stimulated by heregulin and in breast cancer cells with HER-2 gene amplification. , 2000, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[135] L. Norton,et al. Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[136] B. Lehnert,et al. Factors underlying the cell growth-related bystander responses to alpha particles. , 2000, Cancer research.
[137] B. Neel,et al. New Role for Shc in Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway , 2000, Molecular and Cellular Biology.
[138] H. Kung,et al. KFC, a Ste20-like kinase with mitogenic potential and capability to activate the SAPK/JNK pathway , 2000, Oncogene.
[139] I. Fidler,et al. Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. , 2000, Cancer research.
[140] S. Ethier,et al. Radiosensitization of human breast cancer cells by a novel ErbB family receptor tyrosine kinase inhibitor. , 2000, International journal of radiation oncology, biology, physics.
[141] K. Valerie,et al. Role of the p38 and MEK-½/p42/44 MAP Kinase Pathways in the Differential Activation of Human Immunodeficiency Virus Gene Expression by Ultraviolet and Ionizing Radiation , 2000 .
[142] Analysis of genomic rearrangements associated with EGRFvIII expression suggests involvement of Alu repeat elements. , 2000, Neuro-oncology.
[143] John Mendelsohn,et al. The EGF receptor family as targets for cancer therapy , 2000, Oncogene.
[144] A. Bridges,et al. Anticancer efficacy of the irreversible EGFr tyrosine kinase inhibitor PD 0169414 against human tumor xenografts , 2000, Cancer Chemotherapy and Pharmacology.
[145] D. Alessi,et al. Further evidence that 3‐phosphoinositide‐dependent protein kinase‐1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms , 2000, FEBS letters.
[146] R. Muschel,et al. RAS-Mediated Radiation Resistance is not Linked to MAP Kinase Activation in Two Bladder Carcinoma Cell Lines , 2000, Radiation research.
[147] D. Bonneau,et al. Mutations of the human PTEN gene , 2000, Human mutation.
[148] E. Van Obberghen,et al. Effect of Phosphoinositide-Dependent Kinase 1 on Protein Kinase B Translocation and Its Subsequent Activation , 2000, Molecular and Cellular Biology.
[149] D. Stern. Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases , 2000, Breast Cancer Research.
[150] G. Tzivion,et al. Regulation of the Raf-1 kinase domain by phosphorylation and 14-3-3 association. , 2000, The Biochemical journal.
[151] K. Carraway,et al. Ligand discrimination by ErbB receptors: differential signaling through differential phosphorylation site usage , 2000, Oncogene.
[152] E. Mekada,et al. Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cancer cells. , 2000, Cancer research.
[153] John Calvin Reed,et al. MEK/ERK signaling pathway regulates the expression of Bcl‐2, Bcl‐XL, and Mcl‐1 and promotes survival of human pancreatic cancer cells , 2000, Journal of cellular biochemistry.
[154] Paul Dent,et al. Signal Transduction and Cellular Radiation Responses , 2000, Radiation research.
[155] M. Hung,et al. HER-2/neu Blocks Tumor Necrosis Factor-induced Apoptosis via the Akt/NF-κB Pathway* , 2000, The Journal of Biological Chemistry.
[156] J. M. Lin,et al. Interleukin-6 activates phosphatidylinositol-3 kinase, which inhibits apoptosis in human prostate cancer cell lines. , 2000, The Prostate.
[157] D. Slamon,et al. Trastuzumab and chemotherapeutics: drug interactions and synergies. , 2000, Seminars in Oncology.
[158] A. King,et al. Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak , 2000, Current Biology.
[159] M. Mattson,et al. Pro‐apoptotic action of PAR‐4 involves inhibition of NF‐κB activity and suppression of BCL‐2 expression , 2000, Journal of neuroscience research.
[160] M. Klagsbrun,et al. A Natural ErbB4 Isoform That Does Not Activate Phosphoinositide 3-Kinase Mediates Proliferation but Not Survival or Chemotaxis* , 2000, The Journal of Biological Chemistry.
[161] Donald M. O'Rourke,et al. Rationally designed anti-HER2/neu peptide mimetic disables P185HER2/neu tyrosine kinases in vitro and in vivo , 2000, Nature Biotechnology.
[162] B. Vanhaesebroeck,et al. The PI3K-PDK1 connection: more than just a road to PKB. , 2000, The Biochemical journal.
[163] M. C. Hu,et al. HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway. , 2000, The Journal of biological chemistry.
[164] Careen K. Tang,et al. Epidermal growth factor receptor vIII enhances tumorigenicity in human breast cancer. , 2000, Cancer research.
[165] M. Kris,et al. Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[166] K. Valerie,et al. Role of the p38 and MEK‐½/p42/44 MAP Kinase Pathways in the Differential Activation of Human Immunodeficiency Virus Gene Expression by Ultraviolet and Ionizing Radiation , 2000, Photochemistry and photobiology.
[167] P. Dent,et al. Ionizing Radiation-Induced Mitogen-Activated Protein (MAP) Kinase Activation in DU145 Prostate Carcinoma Cells: MAP Kinase Inhibition Enhances Radiation-Induced Cell Killing and G2/M-Phase Arrest , 2000 .
[168] A. Schulze,et al. Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. , 2000, Genes & development.
[169] Jiahuai Han,et al. Involvement of the MKK6-p38γ Cascade in γ-Radiation-Induced Cell Cycle Arrest , 2000, Molecular and Cellular Biology.
[170] Jing Chen,et al. Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK–ERK independent mechanism , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[171] S. Paik,et al. HER-2 and choice of adjuvant chemotherapy in breast cancer. , 2001, Seminars in oncology.
[172] J. Santibañez,et al. ERK 1,2 and p38 pathways are involved in the proliferative stimuli mediated by urokinase in osteoblastic SaOS‐2 cell line , 2001, Journal of cellular biochemistry.
[173] Y. Qiu,et al. Regulation of Akt/PKB Activation by Tyrosine Phosphorylation* , 2001, The Journal of Biological Chemistry.
[174] Y. Yarden,et al. Untangling the ErbB signalling network , 2001, Nature Reviews Molecular Cell Biology.
[175] J. Baselga,et al. Activated extracellular signal-regulated kinases: association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments. , 2001, Cancer research.
[176] T. Suhara,et al. Phosphatidylinositol 3-Kinase/Akt Signaling Controls Endothelial Cell Sensitivity to Fas-Mediated Apoptosis via Regulation of FLICE-Inhibitory Protein (FLIP) , 2001, Circulation research.
[177] U. Rodeck,et al. Epidermal Growth Factor Receptor-dependent Control of Keratinocyte Survival and Bcl-xL Expression through a MEK-dependent Pathway* , 2001, The Journal of Biological Chemistry.
[178] J. Baselga,et al. Mechanism of action of anti-HER2 monoclonal antibodies. , 2001, Annals of oncology : official journal of the European Society for Medical Oncology.
[179] L. Cantley,et al. ERK Regulates the Hepatocyte Growth Factor-mediated Interaction of Gab1 and the Phosphatidylinositol 3-Kinase* , 2001, The Journal of Biological Chemistry.
[180] J. Avruch,et al. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. , 2001, Physiological reviews.
[181] E. Maizels,et al. Developmental regulation of mitogen-activated protein kinase-activated kinases-2 and -3 (MAPKAPK-2/-3) in vivo during corpus luteum formation in the rat. , 2001, Molecular endocrinology.
[182] L. Mahadevan,et al. Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-alpha (TNF-alpha ) mRNA induction. Evidence for selective destabilization of TNF-alpha transcripts. , 2001, The Journal of biological chemistry.
[183] L. Mahadevan,et al. Combinations of ERK and p38 MAPK Inhibitors Ablate Tumor Necrosis Factor-α (TNF-α) mRNA Induction , 2001, The Journal of Biological Chemistry.
[184] G. Mills,et al. Involvement of JNK-mediated pathway in EGF-mediated protection against paclitaxel-induced apoptosis in SiHa human cervical cancer cells , 2001, British Journal of Cancer.
[185] V. Rangnekar,et al. Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression. , 2001, Cancer research.
[186] J. Smyth,et al. Expression of erbB-4/HER-4 growth factor receptor isoforms in ovarian cancer. , 2001, Cancer research.
[187] Ming-Tsan Lin,et al. The involvement of PI 3-K/Akt-dependent up-regulation of Mcl-1 in the prevention of apoptosis of Hep3B cells by interleukin-6 , 2001, Oncogene.
[188] G. Ramadori,et al. in spontaneous apoptosis and in the anti-apoptotic effect of TGF-b or TNF-a on activated hepatic stellate cells , 2001 .
[189] R. Schmidt-Ullrich,et al. The relative role of ErbB1–4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells , 2001, Oncogene.
[190] D. W. Fry,et al. Akt, MAPK (Erk1/2), and p38 Act in Concert to Promote Apoptosis in Response to ErbB Receptor Family Inhibition* , 2001, The Journal of Biological Chemistry.
[191] A. Scott,et al. Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR. , 2001, Cancer research.
[192] J. Manola,et al. Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[193] A. Majumdar,et al. Increased in vitro activation of EGFR by membrane-bound TGF-alpha from gastric and colonic mucosa of aged rats. , 2001, American journal of physiology. Gastrointestinal and liver physiology.
[194] E K Rowinsky,et al. Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[195] N. Guitton,et al. IL-6 a key cytokine in in vitro and in vivo response of Sertoli cells to external gamma irradiation. , 2001, Cytokine.
[196] J. Hofsteenge,et al. Identification of Tyrosine Phosphorylation Sites on 3-Phosphoinositide-dependent Protein Kinase-1 and Their Role in Regulating Kinase Activity* , 2001, The Journal of Biological Chemistry.
[197] S H Kaufmann,et al. The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux. , 2001, Cancer research.
[198] R. Parsons,et al. PTEN: life as a tumor suppressor. , 2001, Experimental cell research.
[199] P. Dennis,et al. Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2. , 2001, Cancer research.
[200] D. Latchman,et al. Cardioprotective Effects of Transforming Growth Factor-&bgr;1 During Early Reoxygenation or Reperfusion Are Mediated by p42/p44 MAPK , 2001, Journal of cardiovascular pharmacology.
[201] R. Schmidt-Ullrich,et al. Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization. , 2001, Journal of the National Cancer Institute.
[202] K. Carraway,et al. Localization and modulation of ErbB receptor tyrosine kinases. , 2001, Current opinion in cell biology.
[203] R. Coffey,et al. Her-2/neu overexpression induces NF-κB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IκB-α that can be inhibited by the tumor suppressor PTEN , 2001, Oncogene.
[204] T. Ching,et al. Specific binding of the C-terminal Src homology 2 domain of the p85alpha subunit of phosphoinositide 3-kinase to phosphatidylinositol 3,4,5-trisphosphate. Localization and engineering of the phosphoinositide-binding motif. , 2001, The Journal of biological chemistry.
[205] C. Leung,et al. Epidermal growth factor induces Gadd45 (growth arrest and DNA damage inducible protein) expression in A431 cells. , 2001, Biochimica et biophysica acta.
[206] J. Mier,et al. Phosphatidylinositol 3-Kinase/Akt Activity Regulates c-FLIP Expression in Tumor Cells* , 2001, The Journal of Biological Chemistry.
[207] J. Blenis,et al. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/− mice , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[208] P. Fisher,et al. Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis. , 2001, Molecular biology of the cell.
[209] Analysis of the transcriptional program induced by Raf in epithelial cells , 2001 .
[210] J. Hancock,et al. Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions , 2001, Oncogene.
[211] M. Takigawa,et al. CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase (ERK). , 2001, European journal of biochemistry.
[212] Kanefusa Kato,et al. Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27 , 2001, Cell stress & chaperones.
[213] T. Tzai,et al. Expression profiles of ErbB family receptors and prognosis in primary transitional cell carcinoma of the urinary bladder. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[214] M. Birnbaum,et al. Neuregulin Signaling through a PI3K/Akt/Bad Pathway in Schwann Cell Survival , 2001, Molecular and Cellular Neuroscience.
[215] Keiji Suzuki,et al. Extremely low-dose ionizing radiation causes activation of mitogen-activated protein kinase pathway and enhances proliferation of normal human diploid cells. , 2001, Cancer research.
[216] S. Kim,et al. BetaPix-enhanced p38 activation by Cdc42/Rac/PAK/MKK3/6-mediated pathway. Implication in the regulation of membrane ruffling. , 2001, The Journal of biological chemistry.
[217] K. Ang,et al. C225 antiepidermal growth factor receptor antibody enhances tumor radiocurability. , 2001, International journal of radiation oncology, biology, physics.
[218] A. Schulze,et al. Analysis of the transcriptional program induced by Raf in epithelial cells , 2001, Nature Genetics.
[219] M. Imamura,et al. Interleukin-6 inhibits radiation induced apoptosis in pancreatic cancer cells. , 2001, Anticancer research.
[220] B. Saile. The bcl, NFκB and p53/p21WAF1 systems are involved in spontaneous apoptosis and in the anti-apoptotic effect of TGF-β or TNF-α on activated hepatic stellate cells , 2001 .
[221] Opposing effect of p38 CCDPK and p44/42 CCDPK signaling on TNF-alpha-induced apoptosis in bovine aortic endothelial cells. , 2001, Acta pharmacologica Sinica.
[222] J. Mendelsohn. The epidermal growth factor receptor as a target for cancer therapy. , 2001, Endocrine-Related Cancer.
[223] A. Ullrich,et al. The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification. , 2001, Endocrine-related cancer.
[224] G. Tortora,et al. Antisense oligonucleotides targeting the epidermal growth factor receptor inhibit proliferation, induce apoptosis, and cooperate with cytotoxic drugs in human cancer cell lines , 2001, International journal of cancer.
[225] M. Jo,et al. Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 breast cancer cells. , 2001, Journal of cell science.
[226] W. Denny. The 4-anilinoquinazoline class of inhibitors of the erbB family of receptor tyrosine kinases. , 2001, Farmaco.
[227] M. Denton,et al. Expression of herstatin, an autoinhibitor of HER-2/neu, inhibits transactivation of HER-3 by HER-2 and blocks EGF activation of the EGF receptor , 2001, Oncogene.
[228] M. Scott,et al. The developmental biology of brain tumors. , 2001, Annual review of neuroscience.
[229] K. Gibson,et al. Studies leading to the identification of ZD1839 (IRESSA): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer. , 2001, Bioorganic & medicinal chemistry letters.
[230] M. Mattson,et al. Effects of NF-κB1 (p50) targeted gene disruption on ionizing radiation-induced NF-κB activation and TNFα, IL-1α, IL-1β and IL-6 mRNA expression in vivo , 2001 .
[231] P. Dent,et al. MAPK dependence of DNA damage repair: ionizing radiation and the induction of expression of the DNA repair genes XRCC1 and ERCC1 in DU145 human prostate carcinoma cells in a MEK1/2 dependent fashion , 2001, International journal of radiation biology.
[232] Peipei Ping,et al. p38 Kinase-dependent MAPKAPK-2 Activation Functions as 3-Phosphoinositide-dependent Kinase-2 for Akt in Human Neutrophils* , 2001, The Journal of Biological Chemistry.
[233] M. Jung,et al. NF-kappa B signaling pathway as a target for human tumor radiosensitization. , 2001, Seminars in radiation oncology.
[234] K. Moelling,et al. Regulation of Raf by Akt Controls Growth and Differentiation in Vascular Smooth Muscle Cells* , 2001, The Journal of Biological Chemistry.
[235] F. Aoudjit,et al. Matrix Attachment Regulates FAS-Induced Apoptosis in Endothelial Cells , 2001, The Journal of cell biology.
[236] B. Kahn,et al. Differential Activation of Protein Kinase B and p70S6K by Glucose and Insulin-like Growth Factor 1 in Pancreatic β-Cells (INS-1)* , 2001, The Journal of Biological Chemistry.
[237] Hua Yu,et al. Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells , 2001, Oncogene.
[238] A. Scott,et al. Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor. , 2001, Cancer research.
[239] R. Schmidt-Ullrich,et al. Radiosensitization of malignant glioma cells through overexpression of dominant-negative epidermal growth factor receptor. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[240] R. Muschel,et al. The Ras radiation resistance pathway. , 2001, Cancer research.
[241] M. Sliwkowski,et al. A naturally occurring secreted human ErbB3 receptor isoform inhibits heregulin-stimulated activation of ErbB2, ErbB3, and ErbB4. , 2001, Cancer research.
[242] D. K. Kuharsky,et al. Relief of Extrinsic Pathway Inhibition by the Bid-dependent Mitochondrial Release of Smac in Fas-mediated Hepatocyte Apoptosis* , 2002, The Journal of Biological Chemistry.
[243] N. Rosen,et al. Degradation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3'-kinase-AKT-dependent pathway. , 2002, Cancer research.
[244] R. Weber,et al. Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[245] T. Katada,et al. Activation of Extracellular Signal-regulated Kinase by Ultraviolet Is Mediated through Src-dependent Epidermal Growth Factor Receptor Phosphorylation , 2002, The Journal of Biological Chemistry.
[246] P. Cohen,et al. MSK1 and MSK2 Are Required for the Mitogen- and Stress-Induced Phosphorylation of CREB and ATF1 in Fibroblasts , 2002, Molecular and Cellular Biology.
[247] P. Tofilon,et al. Inhibition of radiation-induced nuclear factor-kappaB activation by an anti-Ras single-chain antibody fragment: lack of involvement in radiosensitization. , 2002, Cancer research.
[248] Carmel Mothersill,et al. Relationship between Radiation-Induced Low-Dose Hypersensitivity and the Bystander Effect , 2002, Radiation research.
[249] J. Contessa,et al. Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells , 2002, Oncogene.
[250] M. Sarker,et al. Stimulation of the mitogen-activated protein kinase pathway antagonizes TRAIL-induced apoptosis downstream of BID cleavage in human breast cancer MCF-7 cells , 2002, Oncogene.
[251] C. Arteaga,et al. Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases , 2002 .
[252] Mansoor M Ahmed,et al. Par-4, A Pro-Apoptotic Gene, Inhibits Radiation-Induced NFκB Activity and Bcl-2 Expression Leading to Induction of Radiosensitivity in Human Prostate Cancer Cells PC-3 , 2002, Cancer biology & therapy.
[253] G. Salvesen,et al. Apoptosis: IAP proteins: blocking the road to death's door , 2002, Nature Reviews Molecular Cell Biology.
[254] Altered signaling of TNFalpha-TNFR1 and SODD/BAG4 is responsible for radioresistance in human HT-R15 cells. , 2002, Anticancer research.
[255] H. Nakshatri,et al. Identification of signal transduction pathways involved in constitutive NF-κB activation in breast cancer cells , 2002, Oncogene.
[256] John Calvin Reed,et al. Dysregulation of apoptosis genes in hematopoietic malignancies , 2002, Oncogene.
[257] Roy S Herbst,et al. Epidermal growth factor receptors as a target for cancer treatment: the emerging role of IMC-C225 in the treatment of lung and head and neck cancers. , 2002, Seminars in oncology.
[258] Liang Qiao,et al. Roles of ERBB family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival. , 2002, Frontiers in bioscience : a journal and virtual library.
[259] N. Guseva,et al. Contribution of death receptor and mitochondrial pathways to Fas‐mediated apoptosis in the prostatic carcinoma cell line PC3 , 2002, The Prostate.
[260] T. Mak,et al. ERK Activation Mediates Cell Cycle Arrest and Apoptosis after DNA Damage Independently of p53* , 2002, The Journal of Biological Chemistry.
[261] P. Dent,et al. Phosphorylation of the Myosin-binding Subunit of Myosin Phosphatase by Raf-1 and Inhibition of Phosphatase Activity* , 2002, The Journal of Biological Chemistry.
[262] J. Ju,et al. ERK-1/2 and p38 Kinase Oppositely Regulate Nitric Oxide-induced Apoptosis of Chondrocytes in Association with p53, Caspase-3, and Differentiation Status* , 2002, The Journal of Biological Chemistry.
[263] J. McCubrey,et al. The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia , 2002, Leukemia.
[264] Su-Jae Lee,et al. Protein Kinase C{delta} Overexpression Enhances Radiation Sensitivity via Extracellular Regulated Protein Kinase 1/2 Activation, Abolishing the Radiation-induced G2-M Arrest , 2002 .