Correlation and application evaluation of cystatin C with left ventricular diastolic function in patients with polymyositis and / or dermatomyositis

AIM To analyze the relationship between cystatin C and left ventricular diastolic dysfunction in patients with polymyositis (PM) and/or dermatomyositis (DM), and to evaluate its clinical value. METHODS One hundred and twenty-six patients with PM and/or DM were included. The serum cystatin C level was measured by immunoturbidimetry. The left heart function was evaluated by color Doppler echocardiography. The relationship. between cystatin C and left heart function was analyzed by logistic regression. And ROC curve was used to evaluate the diagnostic value of cystatin C for left ventricular dysfunction. RESULTS Compared with those with normal left ventricular diastolic function in PM and/or DM, those with left ventricular diastolic dysfunction were older, cystatin C level was higher (P<0.01), and the positive rate of anti Jo-1 antibody was lower (P<0.01). Logistic regression further shows that cystatin C is closely related to left ventricular diastolic dysfunction (P<0.05). ROC curve showed that the area under the curve of cystatin C was 0.703, the sensitivity, specificity and accuracy of 基金项目:国家自然科学基金青年项目资助(81300243);四川省医学科研青年创新课题资助(Q14013);四川省卫计委普及应用 项目资助(16PJ042) 通讯作者:汪汉,主治医师,主要从事心脏与风湿系统疾病研究 Email:7972348@qq.com 作者简介:王引利,副主任医师,硕士 Email:714689546@qq.com 心 脏 杂 志 (Chin Heart J) 2019,31(2) · 157 ·