The role of cardiorespiratory fitness on plasma lipid levels

Dyslipidemia is a treatable risk factor for cardiovascular disease. Epidemiological studies have demonstrated the importance of treatment for abnormalities in total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides. Aside from pharmacotherapy, exercise and cardio-respiratory fitness have been shown to have beneficial effects on decreasing cardiovascular disease risk. Even though previous data regarding the benefits of exercise on plasma lipids have been somewhat conflicting, numerous studies have demonstrated that exercise increases HDL-cholesterol and reduces the triglyceride levels. Also, smaller, more atherogenic LDL particles seem to decrease with increases in cardio-respiratory fitness and exercise, and favorable blood lipid profiles seem to persist longer through the adult life span.

[1]  J. Hardin,et al.  The effect of cardiorespiratory fitness on age-related lipids and lipoproteins. , 2015, Journal of the American College of Cardiology.

[2]  Joel Stein,et al.  Executive summary: heart disease and stroke statistics--2014 update: a report from the American Heart Association. , 2014, Circulation.

[3]  K. Häkkinen,et al.  Associations of Maximal Strength and Muscular Endurance with Cardiovascular Risk Factors , 2013, International Journal of Sports Medicine.

[4]  Theresa M. Beckie,et al.  The Importance of Cardiorespiratory Fitness in the United States: The Need for a National Registry A Policy Statement From the American Heart Association , 2013, Circulation.

[5]  Neil M. Johannsen,et al.  Physical activity, cardiorespiratory fitness, and exercise training in primary and secondary coronary prevention. , 2013, Circulation journal : official journal of the Japanese Circulation Society.

[6]  E. Ming,et al.  Abstract 12055: Prevalence of Lipid Abnormalities in the United States: The National Health and Nutrition Examination Survey 2003-2006 , 2010 .

[7]  C. van Heyningen.  Clinical Lipidology: A Companion to Braunwald's Heart Disease , 2009 .

[8]  D. Panagiotakos,et al.  Responses of Blood Lipids to Aerobic, Resistance, and Combined Aerobic With Resistance Exercise Training: A Systematic Review of Current Evidence , 2009, Angiology.

[9]  Y. Ohashi,et al.  Effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol: a meta-analysis. , 2007, Archives of internal medicine.

[10]  A. Goldberg,et al.  Endurance exercise training raises high-density lipoprotein cholesterol and lowers small low-density lipoprotein and very low-density lipoprotein independent of body fat phenotypes in older men and women. , 2007, Metabolism: clinical and experimental.

[11]  G. Kelley,et al.  Aerobic exercise and lipids and lipoproteins in patients with cardiovascular disease: a meta-analysis of randomized controlled trials. , 2006, Journal of cardiopulmonary rehabilitation.

[12]  B. Psaty,et al.  Dyslipidemia Prevalence, Treatment, and Control in the Multi-Ethnic Study of Atherosclerosis (MESA): Gender, Ethnicity, and Coronary Artery Calcium , 2006, Circulation.

[13]  Shumei S. Sun,et al.  Lipids, lipoproteins, lifestyle, adiposity and fat-free mass during middle age: the Fels Longitudinal Study , 2006, International Journal of Obesity.

[14]  P. Sorlie,et al.  Trends in serum lipids and lipoproteins of adults, 1960-2002. , 2005, JAMA.

[15]  D. Waters,et al.  Lessons from the PROVE-IT trial. Higher dose of potent statin better for high-risk patients. , 2004, Cleveland Clinic journal of medicine.

[16]  Tomás Pantoja,et al.  Análisis crítico de un artículo Las estatinas reducen la morbi-mortalidad en pacientes de alto riesgo cardiovascular: Heart Protection Study Collaborative Group. (HPS). Lancet 2002; 360: 7-22. , 2003 .

[17]  Samia Mora,et al.  Ability of exercise testing to predict cardiovascular and all-cause death in asymptomatic women: a 20-year follow-up of the lipid research clinics prevalence study. , 2003, JAMA.

[18]  A. Rudnicka,et al.  Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis , 2003, BMJ : British Medical Journal.

[19]  A. Rodgers.  A cure for cardiovascular disease? , 2003, BMJ : British Medical Journal.

[20]  Jae-Hyun Park,et al.  The effect of combined aerobic and resistance exercise training on abdominal fat in obese middle-aged women. , 2003, Journal of physiological anthropology and applied human science.

[21]  C. Lau,et al.  Long-term changes in exercise capacity, quality of life, body anthropometry, and lipid profiles after a cardiac rehabilitation program in obese patients with coronary heart disease. , 2003, The American journal of cardiology.

[22]  A. Tall.  Exercise to reduce cardiovascular risk--how much is enough? , 2002, The New England journal of medicine.

[23]  W. Kraus,et al.  Effects of the amount and intensity of exercise on plasma lipoproteins. , 2002, The New England journal of medicine.

[24]  P. Thompson,et al.  Lipids, lipoproteins, and exercise. , 2002, Journal of cardiopulmonary rehabilitation.

[25]  J. Manson,et al.  Walking compared with vigorous exercise for the prevention of cardiovascular events in women. , 2002, The New England journal of medicine.

[26]  AndrewJ. S. Coats.  MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebocontrolled trial , 2002, The Lancet.

[27]  J. Després,et al.  Reduced HDL particle size as an additional feature of the atherogenic dyslipidemia of abdominal obesity. , 2001, Journal of lipid research.

[28]  C. Bouchard,et al.  Race differences in the response of postheparin plasma lipoprotein lipase and hepatic lipase activities to endurance exercise training in men: results from the HERITAGE Family Study. , 2001, Atherosclerosis.

[29]  M. Sullivan,et al.  Treatment efficacy of intermittent claudication by surgical intervention, supervised physical exercise training compared to no treatment in unselected randomised patients I: one year results of functional and physiological improvements. , 2001, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[30]  C. Bouchard,et al.  Effects of Endurance Exercise Training on Plasma HDL Cholesterol Levels Depend on Levels of Triglycerides: Evidence From Men of the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) Family Study , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[31]  D. Rader,et al.  Does exercise increase HDL cholesterol in those who need it the most? , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[32]  P Langenberg,et al.  Non-high-density lipoprotein cholesterol level as a predictor of cardiovascular disease mortality. , 2001, Archives of internal medicine.

[33]  A. Leon,et al.  Response of blood lipids to exercise training alone or combined with dietary intervention. , 2001, Medicine and science in sports and exercise.

[34]  R. Belardinelli,et al.  Exercise training intervention after coronary angioplasty: the ETICA trial. , 2001, Journal of the American College of Cardiology.

[35]  J. Després,et al.  Blood lipid response to 20 weeks of supervised exercise in a large biracial population: the HERITAGE Family Study. , 2000, Metabolism: clinical and experimental.

[36]  G A Colditz,et al.  A prospective study of walking as compared with vigorous exercise in the prevention of coronary heart disease in women. , 1999, The New England journal of medicine.

[37]  G. Mancia,et al.  Prevention of coronary heart disease in clinical practice: recommendations of the Second Joint Task Force of European and other Societies on Coronary Prevention. , 1998, Atherosclerosis.

[38]  E. Barrett-Connor,et al.  Total, LDL, and HDL cholesterol decrease with age in older men and women. The Rancho Bernardo Study 1984-1994. , 1997, Circulation.

[39]  A. Goldberg,et al.  Increases in high-density lipoprotein cholesterol with endurance exercise training are blunted in obese compared with lean men. , 1997, Metabolism: clinical and experimental.

[40]  M. Pacheco,et al.  Quantum dots under electric and magnetic fields: Impurity-related electronic properties , 1997 .

[41]  P. Thompson,et al.  Effect of prolonged exercise training without weight loss on high-density lipoprotein metabolism in overweight men. , 1997, Metabolism: clinical and experimental.

[42]  K. Metz,et al.  Comparison of Exercise and Normal Variability on HDL Cholesterol Concentrations and Lipolytic Activity , 1996, International journal of sports medicine.

[43]  D. Ballantyne,et al.  A comparison of the effects of strength and aerobic exercise training on exercise capacity and lipids after coronary artery bypass surgery. , 1996, European heart journal.

[44]  R S Paffenbarger,et al.  Exercise intensity and longevity in men. The Harvard Alumni Health Study. , 1995, JAMA.

[45]  R S Paffenbarger,et al.  Changes in physical fitness and all-cause mortality. A prospective study of healthy and unhealthy men. , 1995, JAMA.

[46]  J. Holland,et al.  Miles run per week and high-density lipoprotein cholesterol levels in healthy, middle-aged men. A dose-response relationship. , 1995, Archives of internal medicine.

[47]  K. Anderson,et al.  Determinants of change in total cholesterol and HDL-C with age: the Framingham Study. , 1994, Journal of gerontology.

[48]  A. Tall,et al.  Exercise training decreases plasma cholesteryl ester transfer protein. , 1993, Arteriosclerosis and thrombosis : a journal of vascular biology.

[49]  B. Vellas,et al.  Longitudinal study of dietary intakes and plasma lipids in healthy elderly men and women. , 1992, The American journal of clinical nutrition.

[50]  W. Haskell,et al.  The effects on plasma lipoproteins of a prudent weight-reducing diet, with or without exercise, in overweight men and women. , 1991, The New England journal of medicine.

[51]  C. Bouchard,et al.  Loss of abdominal fat and metabolic response to exercise training in obese women. , 1991, The American journal of physiology.

[52]  P. Thompson,et al.  What do muscles have to do with lipoproteins? , 1990, Circulation.

[53]  F. Gutzwiller,et al.  Effects of long-term, self-monitored exercise on the serum lipoprotein and apolipoprotein profile in middle-aged men. , 1990, Atherosclerosis.

[54]  C. Bouchard,et al.  Heredity and Changes in Plasma Lipids and Lipoproteins after Short‐term Exercise Training in Men , 1988, Arteriosclerosis.

[55]  D. Levy,et al.  Cholesterol and mortality. 30 years of follow-up from the Framingham study. , 1987, JAMA.

[56]  P. Thompson,et al.  Exercise acutely increases high density lipoprotein-cholesterol and lipoprotein lipase activity in trained and untrained men. , 1987, Metabolism: clinical and experimental.

[57]  D. Ballantyne,et al.  High density and low density lipoprotein subfractions in survivors of myocardial infarction and in control subjects. , 1982, Metabolism: clinical and experimental.

[58]  S. Rössner,et al.  Changes in high density lipoprotein subfractions and other lipoproteins induced by exercise , 1981 .

[59]  P. Schnohr,et al.  Increased plasma HDL‐cholesterol and apo A‐1 in sedentary middle‐aged men after physical conditioning , 1980, European journal of clinical investigation.

[60]  R. Paffenbarger,et al.  Physical activity as an index of heart attack risk in college alumni. , 1978, American journal of epidemiology.

[61]  L. Wilhelmsen,et al.  A controlled trial of physical training after myocardial infarction. Effects on risk factors, nonfatal reinfarction, and death. , 1975, Preventive medicine.

[62]  P. Thompson,et al.  Effects of Exercise on Lipid-Lipoproteins , 2015 .

[63]  Cardiovascular Diabetology BioMed Central Original investigation ACE I/D genotype, adiposity, and blood pressure in children , 2009 .

[64]  G. Kelley,et al.  Aerobic exercise and HDL2-C: a meta-analysis of randomized controlled trials. , 2006, Atherosclerosis.

[65]  S. Grundy,et al.  Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. , 2004, Journal of the American College of Cardiology.

[66]  Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. , 2002, Circulation.

[67]  K. DuBose,et al.  Blood Lipid and Lipoprotein Adaptations to Exercise , 2001, Sports medicine.

[68]  H. Tolson,et al.  Training intensity, blood lipids, and apolipoproteins in men with high cholesterol. , 1997, Journal of applied physiology.

[69]  D. Gordon,et al.  High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. , 1989, Circulation.

[70]  R. Krauss,et al.  Increased exercise level and plasma lipoprotein concentrations: a one-year, randomized, controlled study in sedentary, middle-aged men. , 1983, Metabolism: clinical and experimental.

[71]  P. Gorman,et al.  Effect of long-term moderate physical exercise on plasma lipoproteins. The National Exercise and Heart Disease Project. , 1982, Archives of internal medicine.

[72]  S. Rössner,et al.  Changes in high density lipoprotein subfractions and other lipoproteins by exercise. , 1981, Clinica chimica acta; international journal of clinical chemistry.

[73]  C. Plavsic,et al.  The results of "exercise therapy in coronary prone individuals and coronary patients". , 1976, Giornale italiano di cardiologia.