Artificial Esophagus With Peristaltic Movement

In this study, we have developed an artificial esophagus simulating peristaltic movement with the use of a nickel-titanium shape memory alloy (NiTi-SMA) actuator. Serial pairs of NiTi-SMAs were placed around a Gore-Tex vascular graft in a helical position such that they obliterated the lumen of the vessel when they contracted. In an animal experiment using a goat, the cervical esophagus was resected over a length of approximately 20 cm. The artificial esophagus was anastomosed with the remaining cervical esophagus. When a direct current of 500 mA at 5 V was applied to the NiTi-SMAs, the first pair of the NiTi-SMA contracted. The following pairs of the NiTi-SMAs contracted consecutively. The entire contraction of the artificial esophagus was similar to the esophageal peristaltic movement observed by x-ray examination in humans. The results showed the possibility that the artificial esophagus could function as an artificial esophagus having peristaltic movement.

[1]  E. Wiener Gastroesophageal reflux and pulmonary aspiration: Incidence, Functional abnormality, and results of surgical therapy , 1980 .

[2]  Ashok Srinivasan,et al.  Tissue-engineered esophagus: experimental substitution by onlay patch or interposition. , 2003, The Journal of thoracic and cardiovascular surgery.

[3]  Tomoyuki Yambe,et al.  Development of an Implantable Artificial Anal Sphincter by the Use of the Shape Memory Alloy , 2001, ASAIO journal.

[4]  Y. Shimizu,et al.  Intrathoracic Esophageal Replacement with a Collagen Sponge– Silicone Double Layer Tube: Evaluation of Omental-Pedicle Wrapping and Prolonged Placement of an Inner Stent , 2000, ASAIO journal.

[5]  H. Harasaki,et al.  Heat Dissipation through the Blood Contacting Surface of a Thermally Driven LVAS , 1988, The International journal of artificial organs.

[6]  A. Whyte,et al.  Structural deterioration in Celestin tubes , 1976, The British journal of surgery.

[7]  J. Bader [Physiology of the esophagus]. , 1957, Vie medicale.

[8]  Peter J Pronovost,et al.  Variation in postoperative complication rates after high-risk surgery in the United States. , 2003, Surgery.

[9]  D. Skinner Atlas of Esophageal Surgery , 1991 .

[10]  C. Pellegrini,et al.  Gastroesophageal reflux and pulmonary aspiration: incidence, functional abnormality, and results of surgical therapy. , 1979, Surgery.

[11]  R. G. Hughes,et al.  Late complication of endoscopic oesophageal tube insertion. , 1979, British medical journal.

[12]  F. Branicki,et al.  Structural deterioration of prosthetic oesophageal tubes: An in vitro comparison of latex rubber and silicone rubber tubes , 1981, The British journal of surgery.

[13]  V. Caron,et al.  United states. , 2018, Nursing standard (Royal College of Nursing (Great Britain) : 1987).

[14]  Tatsuo Nakamura,et al.  The experimental replacement of a cervical esophageal segment with an artificial prosthesis with the use of collagen matrix and a silicone stent. , 1998, The Journal of thoracic and cardiovascular surgery.

[15]  Julie H. Campbell,et al.  Advances in vascular tissue engineering. , 2003, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.