Chronomics: circadian and circaseptan timing of radiotherapy, drugs, calories, perhaps nutriceuticals and beyond.

We suggest a putative benefit from timing nutriceuticals (substances that are both nutrients and pharmaceuticals) such as antioxidants for preventive or curative health care, based on the proven merits of timing nutrients, drugs, and other treatments, as documented, i.a., in India. The necessity of timing melatonin, a major antioxidant, is noted. A protocol to extend the scope of chronoradiotherapy awaits testing. Imaging in time by mapping rhythms and broader time structures, chronomes, for earliest diagnoses, for example detection of vascular disease risk, is recommended. The study of rhythms and broader chronomes leads to a dynamic functional genomics, guided by imaging in time of free radicals and antioxidants, amongst many other variables.

[1]  A. McKendrick,et al.  DENTAL CARIES AND SUGAR INTAKE , 1975, The Lancet.

[2]  J. Spalding,et al.  Toward a chronotherapy of neoplasia: Tolerance of treatment depends upon host rhythms , 1973, Experientia.

[3]  S. Pençe,et al.  DETERMINATION OF PLASMA FIBRONECTIN AND SERUM C‐REACTIVE PROTEIN IN PATIENTS WITH CEREBROVASCULAR EVENTS , 2003, International journal of clinical practice.

[4]  F. Halberg,et al.  Circadian Timing of Single Daily “Meal” Affects Survival of Mice 1 , 1973, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[5]  G. Cornelissen,et al.  Is motivation influenced by geomagnetic activity? , 2002, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[6]  F Halberg,et al.  Chronobiologic study design in everyday life, clinic and laboratory. , 1980, Chronobiologia.

[7]  F. Neumann,et al.  Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets. , 1997, Circulation.

[8]  G. Cornelissen,et al.  Endothelin-1's Chronome Indicates Diabetic and Vascular Disease Chronorisk , 1997, Peptides.

[9]  M. Woodward,et al.  Distributions of C-reactive protein measured by high-sensitivity assays in apparently healthy men and women from different populations in Europe. , 2003, Clinical chemistry.

[10]  Joe M O'Sullivan,et al.  Accelerated radiation therapy, seven fractions per week, for advanced head and neck cancer--a feasibility study. , 2002, Clinical oncology (Royal College of Radiologists (Great Britain)).

[11]  C. Margarit,et al.  Organ transplantation and broader chronotherapy with lmplantable pump and computer programs for marker rhythm assessment , 1986 .

[12]  R. Singh,et al.  New insights into circadian aspects of health and disease. , 2002, The Journal of the Association of Physicians of India.

[13]  F. Halberg,et al.  24-Hour Rhythms at Several Levels of Integration in Mice on Different Lighting Regimens.∗ , 1958, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[14]  Withers Treatment-Induced Accelerated Human Tumor Growth. , 1993, Seminars in radiation oncology.

[15]  R. Reiter,et al.  NOCTURNAL DECREASES IN NITRIC OXIDE AND CYCLIC GMP CONTENTS IN THE CHICK BRAIN AND THEIR PREVENTION BY LIGHT , 1996, Neurochemistry International.

[16]  W. Hrushesky,et al.  Circadian chemotherapy for gynecological and genitourinary cancers , 2002, Chronobiology international.

[17]  F Halberg,et al.  Circadian meal timing in relation to lighting schedule optimizes catfish body weight gain. , 1982, The Journal of nutrition.

[18]  Randomized clinical trial on 7-day-continuous accelerated irradiation (CAIR) of head and neck cancer - report on 3-year tumour control and normal tissue toxicity. , 2000 .

[19]  C. Fontes-Ribeiro,et al.  Circadian and seasonal variation of endogenous ubiquinone plasma level , 2002, Chronobiology international.

[20]  L. Marzio,et al.  Circadian variations in antioxidant defences and lipid peroxidation in the rat heart. , 1992, Free radical research communications.

[21]  P. Aukrust,et al.  Inflammatory role of platelets in acute coronary syndromes , 2001, Heart.

[22]  F. Halberg,et al.  Circadian placebo and ACTH effects on urinary cortisol in arthritics , 1980, Peptides.

[23]  R. Singh,et al.  Brain-heart connection and the risk of heart attack. , 2002, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[24]  R. Shebuski,et al.  Role of inflammatory mediators in thrombogenesis. , 2002, The Journal of pharmacology and experimental therapeutics.

[25]  P. Ridker,et al.  Inflammatory markers and coronary heart disease. , 2002 .

[26]  J. Cohn,et al.  Abnormalities of vascular compliance in hypertension, aging and heart failure , 1992, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

[27]  A. Adelstein,et al.  DIET AND RISK FACTORS FOR CORONARY HEART DISEASE IN ASIANS IN NORTHWEST LONDON , 1985, The Lancet.

[28]  E. Ahlersová,et al.  Circadian and circaannual oscillations of tissue lipoperoxides in rats. , 1995, Physiological research.

[29]  G. Cornelissen,et al.  About-half-weekly (Circasemiseptan) Component of the Endothelin-1 (ET-1) Chronome and Vascular Disease Risk , 1997, Peptides.

[30]  A. Mahdi,et al.  Circadian periodicity of urinary volume, creatinine and 5-hydroxyindole acetic acid excretion in healthy Indians. , 1999, Life sciences.

[31]  Y. Ichimaru,et al.  Alternating light-darkness-influenced human electrocardiographic magnetoreception in association with geomagnetic pulsations. , 2000, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[32]  J. Nadler,et al.  Role of inflammatory pathways in the development and cardiovascular complications of type 2 diabetes , 2002, Current diabetes reports.

[33]  G. Hale Sun-spots as Magnets and the Periodic Reversal of their Polarity , 1924, Nature.

[34]  Heinrich Schwabe,et al.  Sonnen — Beobachtungen im Jahre 1843 , 1844 .

[35]  F. Lévi,et al.  Cancer chronotherapy: Principles, applications, and perspectives , 2003, Cancer.

[36]  F. Halberg,et al.  Regular Diurnal Physiological Variation in Eosinophil Levels in Five Stocks of Mice.∗ , 1950, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[37]  C. Heeschen,et al.  Serum Level of the Antiinflammatory Cytokine Interleukin-10 Is an Important Prognostic Determinant in Patients With Acute Coronary Syndromes , 2003, Circulation.

[38]  M. Di Napoli,et al.  C-reactive protein and blood pressure in the acute phase after an ischemic stroke. , 2003, Stroke.

[39]  S. Parthasarathy,et al.  Antioxidants, atherosclerosis and thrombosis. , 1996, Prostaglandins, leukotrienes, and essential fatty acids.

[40]  Peter Libby,et al.  Current Concepts of the Pathogenesis of the Acute Coronary Syndromes , 2001, Circulation.

[41]  H. Simpson,et al.  Toward a chronopsy: part II. A thermopsy revealing asymmetrical circadian variation in surface temperature of human female breasts and related studies. , 1979, Chronobiologia.

[42]  H. Canatan,et al.  Daily rhythm of glutathione peroxidase activity, lipid peroxidation and glutathione levels in tissues of pinealectomized rats , 2002, Neuroscience Letters.

[43]  A. Becker,et al.  Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. , 1994, Circulation.

[44]  V. Menon,et al.  Effect of chronic ethanol ingestion on biochemical circadian rhythms in Wistar rats. , 1999, Alcohol.

[45]  Y. Jang,et al.  C-reactive protein in stable angina patients without peripheral vascular disease. , 2003, International journal of cardiology.

[46]  G. Cornelissen,et al.  About 8- and ∼84-h rhythms in endotheliocytes as in endothelin-1 and effect of trauma , 2001, Peptides.

[47]  A. Reinberg,et al.  Introduction to Chronobiology , 1983 .

[48]  G. Cornelissen,et al.  Engineering and governmental challenge: 7-day/24-hour chronobiologic blood pressure and heart rate screening: Part II. , 2002, Biomedical instrumentation & technology.

[49]  G. Cornelissen,et al.  From experimental units to unique experiments: chronobiologic pilots complement large trials. , 1992, In vivo.

[50]  G. Cornelissen,et al.  Physical chemistry and the biologic week in the perspective of chrono-oncology. , 1995, In Vivo.

[51]  New approaches to screening for vascular and cardiac risk. , 2001, American journal of hypertension.

[52]  R. Singh,et al.  Coronary Artery Disease and Coronary Risk Factors: The South Asian Paradox , 2001 .

[53]  P. Libby,et al.  Inflammation and Atherothrombosis , 2001, Annals of the New York Academy of Sciences.

[54]  A. Loeckinger,et al.  About 8-Hour Variation of Circulating Human Endothelin-1 , 1998, Peptides.

[55]  F Halberg,et al.  Inferential statistical methods for estimating and comparing cosinor parameters. , 1982, Chronobiologia.

[56]  F. Halberg,et al.  Multifrequency rhythms of immunological functions. , 1988, Chronobiologia.

[57]  H. Withers Biological basis of radiation therapy for cancer , 1992, The Lancet.

[58]  P. Ridker,et al.  Inflammatory bio‐markers and cardiovascular risk prediction , 2002, Journal of internal medicine.

[59]  H. Bartsch,et al.  Effect of melatonin on experimental tumors under different photoperiods and times of administration , 2005, Journal of Neural Transmission.

[60]  D. Pizzarello,et al.  Variations in Survival Time after Whole-Body Radiation at Two Times of Day , 1963, Science.

[61]  G. Cornelissen,et al.  The week, inherited in neonatal human twins, found also in geomagnetic pulsations in isolated Antarctica. , 2000, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[62]  F. Halberg,et al.  Season's appreciations 2000: Chronomics complement, among many other fields, genomics and proteomics , 2001 .

[63]  V. Fuster,et al.  Coronary plaque disruption. , 1995, Circulation.

[64]  G. Cornelissen,et al.  Prophylactic Aspirin Treatment: The Merits of Timing , 1991 .

[65]  V. Menon,et al.  Lithium modulates biochemical circadian rhythms in Wistar rats. , 1998, Chronobiology international.

[66]  J. M. Taylor,et al.  Dose-response relationship for radiation therapy of subclinical disease. , 1995, International journal of radiation oncology, biology, physics.

[67]  M. Marmot,et al.  Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians , 1991, The Lancet.

[68]  F. Halberg Temporal coordination of physiologic function. , 1960, Cold Spring Harbor symposia on quantitative biology.

[69]  G. Cornelissen,et al.  Phase-zero trial of clinical chronoradiotherapy of lung cancer , 1994 .

[70]  Bohumil Fišer,et al.  Non-photic solar associations of heart rate variability and myocardial infarction , 2002 .

[71]  N Rifai,et al.  High-sensitivity C-reactive protein and atherosclerosis: from theory to therapy. , 2000, Clinical biochemistry.

[72]  T. Anderson Nitric Oxide, Atherosclerosis and the Clinical Relevance of Endothelial Dysfunction , 2004, Heart Failure Reviews.

[73]  T. Pringle,et al.  Circadian variation of white blood cell aggregation and free radical indices in men with ischaemic heart disease. , 1992, European heart journal.

[74]  P. Ridker,et al.  Novel clinical markers of vascular wall inflammation. , 2001, Circulation research.

[75]  G. Cornelissen,et al.  Circadian telomerase activity and DNA synthesis for timing peptide administration , 2003, Peptides.

[76]  R. Hermida,et al.  Circadian variation in oxidative stress markers in healthy and type II diabetic men , 2002, Chronobiology international.

[77]  D. Galaris,et al.  C-reactive protein and oxidative stress in atrial fibrillation. , 2003, International journal of cardiology.

[78]  M. Marmot,et al.  Association of Early‐Onset Coronary Heart Disease in South Asian Men With Glucose Intolerance and Hyperinsulinemia , 1993, Circulation.

[79]  F. Halberg,et al.  Age and catecholamine rhythms. , 1974, Chronobiologia.

[80]  M. Marmot,et al.  Relationship of glucose intolerance and hyperinsulinaemia to body fat pattern in South Asians and Europeans , 1992, Diabetologia.

[81]  N Rifai,et al.  High-sensitivity C-reactive protein: a novel and promising marker of coronary heart disease. , 2001, Clinical chemistry.

[82]  D. Pizzarello,et al.  Circadian Rhythmicity in the Sensitivity of Two Strains of Mice to Whole-Body Radiation , 1964, Science.

[83]  F. Halberg,et al.  Relation of visual factors to eosinophil rhythm in mice. , 1954, The American journal of physiology.

[84]  G. Cornelissen,et al.  Clinical trials: the larger the better? , 1993, Chronobiologia.

[85]  C. Starkey,et al.  Prevention of coronary artery disease: the south Asian paradox , 2003, The Lancet.

[86]  G. Cornelissen,et al.  Near 10-year and longer periods modulate circadians: intersecting anti-aging and chronoastrobiological research. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.