A13510 Mobile phone text-messaging interventions aimed to prevent cardiovascular diseases (Text2PreventCVD): a systematic review and individual patient data meta-analysis

Objectives: To investigate the effects of text-messaging interventions for cardiovascular disease prevention. Methods: A systematic review to identify relevant randomised controlled trials investigating a text-messaging intervention with a follow-up of period of at least 6 months in adults, focusing on CVD prevention were included. The primary outcome was blood pressure. Authors of studies meeting the inclusion criteria were invited to join the Text2PreventCVD Collaboration. We used standard and IPD meta-analyses using a fixed-effects model to present the results accounting for clustering of patients within studies with adjustments for baseline values. Sensitivity analyses included random-effects models, traditional two-stage approaches using both random and fixed-effects meta-analyses. Results: Nine trials were included in the systematic review involving 3779 participants. At the end of follow-up, standard meta-analysis showed that the weighted mean difference in systolic BP was − 5.41 mmHg (95% CI − 6.50 to − 4.31, p < 0.001). In the IPD meta-analysis of five trials, the mean difference in systolic BP at the end of the follow-up period was − 3.1 mmHg (−4.4 to -.17, p < 0.001). With respect to secondary outcomes, the mean difference in diastolic BP and BMI were − 1.3 mmHg (−2.2 to − 0.5, p = 0.0018) and − 0.5 (−0.7 to − 0.3, p =  < 0.001) respectively. There was insufficient data to examine the impact on other CVRFs of LDL-cholesterol, smoking or quality of life. Conclusion: Mobile phone text messaging interventions have a significant impact on BP and BMI.